Akira Tanikawa1, Takeshi Soma2, Atsuya Miki1,3,4, Shizuka Koh1,3, Yoshiyuki Kitaguchi1, Naoyuki Maeda1,5, Yoshinori Oie1, Satoshi Kawasaki1, Kohji Nishida1,6. 1. Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita Osaka, 565-0871, Japan. 2. Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita Osaka, 565-0871, Japan. soma@ophthal.med.osaka-u.ac.jp. 3. Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan. 4. Department of Myopia Control Research, Aichi Medical University, Aichi, Japan. 5. Kozaki Eye Clinic, Osaka, Japan. 6. Life and Medical Science Frontier Research Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University Graduate School of Medicine, Osaka, Japan.
Abstract
PURPOSE: To evaluate the corneal biomechanical features of eyes with granular corneal dystrophy type 2 (GCD2) by analyzing corneal biomechanical indices obtained using a Corvis ST (CST) dynamic ultra-high-speed Scheimpflug imaging device. METHODS: In this retrospective case-control study, 35 CST parameters were compared in normal eyes (control) and eyes of patients with GCD2 treated at Osaka University Hospital, Osaka, Japan. The parameters included the Corvis Biomechanical Index (CBI), which is important in differentiating eyes with keratoconus from normal eyes. We measured the deposition rates of lesions in the central 7-mm region of the eye and assessed the correlation between the deposition rate and the CBI. RESULTS: Twenty-one eyes with GCD2 and 23 control eyes were analyzed. Eyes with GCD2 showed significantly less corneal stiffness in 15 CST parameters than did control eyes. In particular, the CBI was remarkably higher in eyes with GCD2 than in control eyes (P = 0.000006). Additionally, the deposition rate and the CBI were positively correlated. CONCLUSIONS: GCD2 eyes had softer corneas than did control eyes in most biomechanical CST parameters, and one of the parameters (the CBI) was linked to the rate of deposited lesions. Since IOP may be underestimated in GCD2 eyes, management should be especially careful in GCD2 cases complicated by glaucoma.
PURPOSE: To evaluate the corneal biomechanical features of eyes with granular corneal dystrophy type 2 (GCD2) by analyzing corneal biomechanical indices obtained using a Corvis ST (CST) dynamic ultra-high-speed Scheimpflug imaging device. METHODS: In this retrospective case-control study, 35 CST parameters were compared in normal eyes (control) and eyes of patients with GCD2 treated at Osaka University Hospital, Osaka, Japan. The parameters included the Corvis Biomechanical Index (CBI), which is important in differentiating eyes with keratoconus from normal eyes. We measured the deposition rates of lesions in the central 7-mm region of the eye and assessed the correlation between the deposition rate and the CBI. RESULTS: Twenty-one eyes with GCD2 and 23 control eyes were analyzed. Eyes with GCD2 showed significantly less corneal stiffness in 15 CST parameters than did control eyes. In particular, the CBI was remarkably higher in eyes with GCD2 than in control eyes (P = 0.000006). Additionally, the deposition rate and the CBI were positively correlated. CONCLUSIONS: GCD2 eyes had softer corneas than did control eyes in most biomechanical CST parameters, and one of the parameters (the CBI) was linked to the rate of deposited lesions. Since IOP may be underestimated in GCD2 eyes, management should be especially careful in GCD2 cases complicated by glaucoma.
Authors: Renato Ambrósio; Fernando Faria Correia; Bernardo Lopes; Marcella Q Salomão; Allan Luz; Daniel G Dawson; Ahmed Elsheikh; Riccardo Vinciguerra; Paolo Vinciguerra; Cynthia J Roberts Journal: Open Ophthalmol J Date: 2017-07-31
Authors: Riccardo Vinciguerra; Salwah Rehman; Neeru A Vallabh; Mark Batterbury; Gabriela Czanner; Anshoo Choudhary; Robert Cheeseman; Ahmed Elsheikh; Colin E Willoughby Journal: Br J Ophthalmol Date: 2019-03-28 Impact factor: 4.638