Literature DB >> 36177089

Adapting Clinical Systems to Enable Adolescents' Genomic Choices.

Cynthia A Prows1, Keith Marsolo2, Melanie F Myers3, Jeremy Nix4, Eric S Hall4.   

Abstract

Background: We offered adolescents personalized choices about the type of genetic results they wanted to learn during a research study and created a workflow to filter and transfer the results to the electronic health record (EHR).
Methods: We describe adaptations needed to ensure that adolescents' results documented in the EHR and returned to adolescent/parent dyads matched their choices. A web application enabled manual modification of the underlying laboratory report data based on adolescents' choices. The final PDF format of the laboratory reports was not viewable through the EHR patient portal, so an EHR form was created to support the manual entry of discrete results that could be viewed in the portal.
Results: Enabling adolescents' choices about genetic results was a labor-intensive process. More than 350 hours was required for development of the application and EHR form, as well as over 50 hours of a study professional's time to enter choices into the application and EHR. Adolescents and their parents who learned genetic results through the patient portal indicated that they were satisfied with the method of return and would make their choices again if given the option.
Conclusion: Although future EHR upgrades are expected to enable patient portal access to PDFs, additional improvements are needed to allow the results to be partitioned and filtered based on patient preferences. Furthermore, separating these results into more discrete components will allow them to be stored separately in the EHR, supporting the use of these data in clinical decision support or artificial intelligence applications.

Entities:  

Keywords:  clinical information systems; electronic health records and systems; facilitators and barriers; general aspects; implementation and deployment; patient records; specific types

Year:  2020        PMID: 36177089      PMCID: PMC9518747          DOI: 10.1055/s-0040-1718747

Source DB:  PubMed          Journal:  ACI open        ISSN: 2566-9346


  16 in total

Review 1.  Next-Generation Sequencing to Diagnose Suspected Genetic Disorders.

Authors:  David R Adams; Christine M Eng
Journal:  N Engl J Med       Date:  2018-10-04       Impact factor: 91.245

2.  Understanding variations in secondary findings reporting practices across U.S. genome sequencing laboratories.

Authors:  Sara L Ackerman; Barbara A Koenig
Journal:  AJOB Empir Bioeth       Date:  2017-12-21

3.  Technical desiderata for the integration of genomic data with clinical decision support.

Authors:  Brandon M Welch; Karen Eilbeck; Guilherme Del Fiol; Laurence J Meyer; Kensaku Kawamoto
Journal:  J Biomed Inform       Date:  2014-06-12       Impact factor: 6.317

4.  Adolescents' and Parents' Genomic Testing Decisions: Associations With Age, Race, and Sex.

Authors:  Melanie F Myers; Lisa J Martin; Cynthia A Prows
Journal:  J Adolesc Health       Date:  2019-11-01       Impact factor: 5.012

5.  Technical desiderata for the integration of genomic data into Electronic Health Records.

Authors:  Daniel R Masys; Gail P Jarvik; Neil F Abernethy; Nicholas R Anderson; George J Papanicolaou; Dina N Paltoo; Mark A Hoffman; Isaac S Kohane; Howard P Levy
Journal:  J Biomed Inform       Date:  2011-12-27       Impact factor: 6.317

6.  Giving adolescents a voice: the types of genetic information adolescents choose to learn and why.

Authors:  Josie Pervola; Melanie F Myers; Michelle L McGowan; Cynthia A Prows
Journal:  Genet Med       Date:  2018-10-29       Impact factor: 8.822

7.  Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics.

Authors:  Sarah S Kalia; Kathy Adelman; Sherri J Bale; Wendy K Chung; Christine Eng; James P Evans; Gail E Herman; Sophia B Hufnagel; Teri E Klein; Bruce R Korf; Kent D McKelvey; Kelly E Ormond; C Sue Richards; Christopher N Vlangos; Michael Watson; Christa L Martin; David T Miller
Journal:  Genet Med       Date:  2016-11-17       Impact factor: 8.822

8.  Participant choices for return of genomic results in the eMERGE Network.

Authors:  Christin Hoell; Julia Wynn; Luke V Rasmussen; Keith Marsolo; Sharon A Aufox; Wendy K Chung; John J Connolly; Robert R Freimuth; David Kochan; Hakon Hakonarson; Margaret Harr; Ingrid A Holm; Iftikhar J Kullo; Philip E Lammers; Kathleen A Leppig; Nancy D Leslie; Melanie F Myers; Richard R Sharp; Maureen E Smith; Cynthia A Prows
Journal:  Genet Med       Date:  2020-07-16       Impact factor: 8.864

9.  Genomic Information for Clinicians in the Electronic Health Record: Lessons Learned From the Clinical Genome Resource Project and the Electronic Medical Records and Genomics Network.

Authors:  Marc S Williams; Casey Overby Taylor; Nephi A Walton; Scott R Goehringer; Samuel Aronson; Robert R Freimuth; Luke V Rasmussen; Eric S Hall; Cynthia A Prows; Wendy K Chung; Alexander Fedotov; Jordan Nestor; Chunhua Weng; Robb K Rowley; Georgia L Wiesner; Gail P Jarvik; Guilherme Del Fiol
Journal:  Front Genet       Date:  2019-10-29       Impact factor: 4.599

10.  Rapid whole-genome sequencing decreases infant morbidity and cost of hospitalization.

Authors:  Lauge Farnaes; Amber Hildreth; Nathaly M Sweeney; Michelle M Clark; Shimul Chowdhury; Shareef Nahas; Julie A Cakici; Wendy Benson; Robert H Kaplan; Richard Kronick; Matthew N Bainbridge; Jennifer Friedman; Jeffrey J Gold; Yan Ding; Narayanan Veeraraghavan; David Dimmock; Stephen F Kingsmore
Journal:  NPJ Genom Med       Date:  2018-04-04       Impact factor: 8.617

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