| Literature DB >> 36170287 |
Conor Wall1, Dylan Powell1, Fraser Young1, Aaron J Zynda2, Sam Stuart3, Tracey Covassin2, Alan Godfrey1.
Abstract
Mild traumatic brain injury (mTBI or concussion) is receiving increased attention due to the incidence in contact sports and limitations with subjective (pen and paper) diagnostic approaches. If an mTBI is undiagnosed and the athlete prematurely returns to play, it can result in serious short-term and/or long-term health complications. This demonstrates the importance of providing more reliable mTBI diagnostic tools to mitigate misdiagnosis. Accordingly, there is a need to develop reliable and efficient objective approaches with computationally robust diagnostic methods. Here in this pilot study, we propose the extraction of Mel Frequency Cepstral Coefficient (MFCC) features from audio recordings of speech that were collected from athletes engaging in rugby union who were diagnosed with an mTBI or not. These features were trained on our novel particle swarm optimised (PSO) bidirectional long short-term memory attention (Bi-LSTM-A) deep learning model. Little-to-no overfitting occurred during the training process, indicating strong reliability of the approach regarding the current test dataset classification results and future test data. Sensitivity and specificity to distinguish those with an mTBI were 94.7% and 86.2%, respectively, with an AUROC score of 0.904. This indicates a strong potential for the deep learning approach, with future improvements in classification results relying on more participant data and further innovations to the Bi-LSTM-A model to fully establish this approach as a pragmatic mTBI diagnostic tool.Entities:
Mesh:
Year: 2022 PMID: 36170287 PMCID: PMC9518857 DOI: 10.1371/journal.pone.0274395
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.752
Fig 1Four main steps of the MFCC feature extraction process.
Fig 2Bi-LMST-A model from audio dataset clockwise, displaying steps from the pre-processing phase to prediction evaluation phase.
Participant inclusion and exclusion criteria.
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| ≥18 years. | Be a pregnant female. |
| Have minimal cognitive impairment, defined as a score between 0 and 8 on the Short-Blessed test for cognitive function. | Be unable to abstain from medication/alcohol 24 hours in advance of testing |
| English as a first language or fluency. | Have history of peripheral vestibular pathology or eye movement deficits. |
| Those that have an mTBI/concussion during the season must have a diagnosis of mTBI from a healthcare professional (physiotherapist or medic) based upon standard criteria or identified head injury from their contact sport governing body. | Medical history of a neurological illness that could grossly affect balance or coordination (e.g.. stroke, greater than mild TBI, lower-extremity amputation, recent lower extremity or spine orthopaedic injury requiring a profile). |
Bi-LSTM-A model architecture.
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| L1 | Bidirectional LSTM | 512 |
| L2 | LSTM | 256 |
| L3 | Attention Mechanism | 512 |
| L4 | Dense | 128 |
| L5 | Dropout | 0.6 |
| L6 | Dense | 64 |
| L7 | Fully Connected Dense ( | 2 |
Bi-LSTM-A model optimised hyper-parameters.
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| Learning rate | 0.0001 |
| Batch size | 128 |
| Epochs | 89 |
| Momentum | 0.9 |
Fig 3Bi-LSTM-A training and validation loss.
Fig 4Confusion matrix of the Bi-LSTM-A model classification.
Fig 5ROC curve of classification results.