Grayson G Cole1, Cláudia M Salgado2, Danielle Vargas de Stefano2, Eduardo V Zambrano2, Ana M Gómez2, Miguel Reyes-Múgica2, Qian Wang3. 1. Department of Diagnostic Sciences, Oral and Maxillofacial Pathology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA. 2. Department of Pathology, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA, 152240, USA. 3. Department of Pathology, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA, 152240, USA. wangq7@upmc.edu.
Abstract
BACKGROUND: Acinic cell carcinoma (AciCC) is the second most common pediatric malignant salivary gland tumor. However, there are limited pathology publications about this tumor in the pediatric population. METHODS: We describe four pediatric AciCC cases diagnosed between 2000 and 2021 in our institute. Reticulin histochemistry plus immunohistochemistry for NR4A3 and DOG1 were performed on all cases. RESULTS: Histologically, all four cases featured a tumor-associated lymphoid proliferation and collagenous stroma, in which two formed central scars. The tumors were predominantly solid, with a lobular pattern and variably sized dilated spaces, including one case with focal microcysts. High-grade transformation was not observed in any of our cases. Reticulin stain and immunohistochemistry for NR4A3 showed distinct features between AciCC and non-neoplastic salivary gland parenchyma. DOG1 immunohistochemistry confirmed the acinar origin of AciCC. CONCLUSIONS: Our study reveals that pediatric AciCCs often present with tumor-associated lymphoid proliferation (TALP) and sclerosis. Special stains such as reticulin histochemistry and NR4A3 immunohistochemistry are helpful to separate tumor from adjacent benign parenchyma. The ancillary study is helpful for the diagnosis of small specimens. Our study is limited by its low case number, but we hope that our results will promote more studies on this rare salivary gland tumor in the pediatric population.
BACKGROUND: Acinic cell carcinoma (AciCC) is the second most common pediatric malignant salivary gland tumor. However, there are limited pathology publications about this tumor in the pediatric population. METHODS: We describe four pediatric AciCC cases diagnosed between 2000 and 2021 in our institute. Reticulin histochemistry plus immunohistochemistry for NR4A3 and DOG1 were performed on all cases. RESULTS: Histologically, all four cases featured a tumor-associated lymphoid proliferation and collagenous stroma, in which two formed central scars. The tumors were predominantly solid, with a lobular pattern and variably sized dilated spaces, including one case with focal microcysts. High-grade transformation was not observed in any of our cases. Reticulin stain and immunohistochemistry for NR4A3 showed distinct features between AciCC and non-neoplastic salivary gland parenchyma. DOG1 immunohistochemistry confirmed the acinar origin of AciCC. CONCLUSIONS: Our study reveals that pediatric AciCCs often present with tumor-associated lymphoid proliferation (TALP) and sclerosis. Special stains such as reticulin histochemistry and NR4A3 immunohistochemistry are helpful to separate tumor from adjacent benign parenchyma. The ancillary study is helpful for the diagnosis of small specimens. Our study is limited by its low case number, but we hope that our results will promote more studies on this rare salivary gland tumor in the pediatric population.
Authors: Iyad Sultan; Carlos Rodriguez-Galindo; Sereen Al-Sharabati; Marco Guzzo; Michela Casanova; Andrea Ferrari Journal: Head Neck Date: 2010-11-10 Impact factor: 3.147
Authors: Brendo Vinícius Rodrigues Louredo; Alan Roger Santos-Silva; Pablo Agustin Vargas; Márcio Ajudarte Lopes; Manoela Domingues Martins; Eliete Neves da Silva Guerra; Ana Carolina Prado Ribeiro; Thaís Bianca Brandão; Regina Maria Holanda de Mendonça; Luiz Paulo Kowalski; Paul M Speight; Syed Ali Khurram; Maria Eduarda Pérez-de-Oliveira Journal: J Oral Pathol Med Date: 2021-01-08 Impact factor: 4.253