BACKGROUND: Salivary gland carcinomas are rare malignancies, particularly in young individuals in whom only scanty data are available from published studies. METHODS: We searched the SEER database (1973-2006) for patients with a reported diagnosis of salivary gland carcinoma; children/adolescents (<20 years old) were compared with adults. RESULTS: We identified 263 children/adolescents (58% girls) and 12,571 adults (43% women). The most common histology was mucoepidermoid carcinoma in both groups, but the percentages of other histologies were different. Children/adolescents had more favorable features with most tumors being localized, with no extension to adjacent tissues or lymphatic spread (76% vs 50% in adults, p < .001). Also most tumors were well differentiated or moderately differentiated (88% vs 49% in adults, p < .001). The 5-year overall survival for children/adolescents was 95% ± 1.5%, compared with 59% ± 0.5% for adults (p < .001). CONCLUSION: When compared with adults, salivary gland carcinomas in children/adolescents are less advanced, and have more favorable features and better outcome.
BACKGROUND:Salivary gland carcinomas are rare malignancies, particularly in young individuals in whom only scanty data are available from published studies. METHODS: We searched the SEER database (1973-2006) for patients with a reported diagnosis of salivary gland carcinoma; children/adolescents (<20 years old) were compared with adults. RESULTS: We identified 263 children/adolescents (58% girls) and 12,571 adults (43% women). The most common histology was mucoepidermoid carcinoma in both groups, but the percentages of other histologies were different. Children/adolescents had more favorable features with most tumors being localized, with no extension to adjacent tissues or lymphatic spread (76% vs 50% in adults, p < .001). Also most tumors were well differentiated or moderately differentiated (88% vs 49% in adults, p < .001). The 5-year overall survival for children/adolescents was 95% ± 1.5%, compared with 59% ± 0.5% for adults (p < .001). CONCLUSION: When compared with adults, salivary gland carcinomas in children/adolescents are less advanced, and have more favorable features and better outcome.
Authors: Olga Micol Martínez; Elena Daghoum Dorado; María Dolores Amorós García; María Isabel Oviedo Ramírez; Isabel de la Fuente Muñoz; Jose Luis Fuster Soler Journal: Rare Tumors Date: 2016-10-06
Authors: Grayson G Cole; Cláudia M Salgado; Danielle Vargas de Stefano; Eduardo V Zambrano; Ana M Gómez; Miguel Reyes-Múgica; Qian Wang Journal: Head Neck Pathol Date: 2022-09-28
Authors: Stephen R Grant; David R Grosshans; Stephen D Bilton; John A Garcia; Mayank Amin; Mark S Chambers; Susan L McGovern; Mary F McAleer; William H Morrison; Winston W Huh; Michael E Kupferman; Anita Mahajan Journal: Radiother Oncol Date: 2015-07-28 Impact factor: 6.280
Authors: Alper Cesmebasi; Abigail Gabriel; Daniel Niku; Karolina Bukala; Joseph Donnelly; Paul J Fields; R Shane Tubbs; Marios Loukas Journal: Med Sci Monit Date: 2014-12-04