Paramita Khairan1,2, Tomotaka Sobue3, Ehab Salah Eshak4,5, Tetsuhisa Kitamura1, Motoki Iwasaki6,7, Manami Inoue6,8, Taiki Yamaji7, Hiroyasu Iso5, Shoichiro Tsugane6,9, Norie Sawada6. 1. Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita Osaka, Japan. 2. Department of Internal Medicine, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia. 3. Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita Osaka, Japan. tsobue@envi.med.osaka-u.ac.jp. 4. Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minya, Egypt. 5. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita Osaka, Japan. 6. Division of Cohort research, National Cancer Center Institute for Cancer Control, Tokyo, Japan. 7. Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan. 8. Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan. 9. National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
Abstract
BACKGROUND/ OBJECTIVES: Evidence on the association between sugary drink consumption and gastric cancer (GC) risk is limited, especially in Asian populations. This study aimed to investigate the association between consumption of sugary drinks (sugar-sweetened beverages and 100% fruit juices) and GC risk in a Japanese population. SUBJECTS/ METHODS: This study included 74,455 Japanese individuals aged 45-74 years (35,102 males and 39,353 females) who participated in a population-based cohort study (Japan Public Health Center-based Prospective Study). Sugary drinks were assessed using a food frequency questionnaire. Cox proportional hazard regression was used to obtain hazard ratios (HRs) and 95% confidence intervals (CIs) of GC incidence according to the quintile of sugary drink consumption. RESULTS: We identified 2141 patients with GC cases during 16.7 years of follow-up. Sugary drink consumption was not associated with GC risk. The multivariate HR of total, cardia, and non-cardia GC in the highest vs. lowest quintile of sugary drinks consumption in males was 0.98 (95% CI: 0.82-1.17; p-trend 0.48), 0.48 (95% CI: 0.23-0.99; p-trend 0.03), and 1.03 (95% CI: 0.86-1.24; p-trend 0.88), respectively. In females, the respective multivariate HRs were 1.03 (95% CI: 0.79-1.33; p-trend 0.47), 1.28 (95% CI: 0.32-5.12; p-trend 0.53), and 1.01 (95% CI: 0.78-1.32; p-trend 0.56). The results did not change significantly after adjusting for Helicobacter pylori infection and atrophic gastritis status in the subgroup analysis. CONCLUSIONS: In this Japanese prospective cohort study, sugary drink consumption was not associated with GC risk.
BACKGROUND/ OBJECTIVES: Evidence on the association between sugary drink consumption and gastric cancer (GC) risk is limited, especially in Asian populations. This study aimed to investigate the association between consumption of sugary drinks (sugar-sweetened beverages and 100% fruit juices) and GC risk in a Japanese population. SUBJECTS/ METHODS: This study included 74,455 Japanese individuals aged 45-74 years (35,102 males and 39,353 females) who participated in a population-based cohort study (Japan Public Health Center-based Prospective Study). Sugary drinks were assessed using a food frequency questionnaire. Cox proportional hazard regression was used to obtain hazard ratios (HRs) and 95% confidence intervals (CIs) of GC incidence according to the quintile of sugary drink consumption. RESULTS: We identified 2141 patients with GC cases during 16.7 years of follow-up. Sugary drink consumption was not associated with GC risk. The multivariate HR of total, cardia, and non-cardia GC in the highest vs. lowest quintile of sugary drinks consumption in males was 0.98 (95% CI: 0.82-1.17; p-trend 0.48), 0.48 (95% CI: 0.23-0.99; p-trend 0.03), and 1.03 (95% CI: 0.86-1.24; p-trend 0.88), respectively. In females, the respective multivariate HRs were 1.03 (95% CI: 0.79-1.33; p-trend 0.47), 1.28 (95% CI: 0.32-5.12; p-trend 0.53), and 1.01 (95% CI: 0.78-1.32; p-trend 0.56). The results did not change significantly after adjusting for Helicobacter pylori infection and atrophic gastritis status in the subgroup analysis. CONCLUSIONS: In this Japanese prospective cohort study, sugary drink consumption was not associated with GC risk.
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