OBJECTIVE: To test the hypothesis that more frequent consumption of sugar-sweetened soft drinks would be associated with increased risk of obesity-related cancers. Associations for artificially sweetened soft drinks were assessed for comparison. DESIGN: Prospective cohort study with cancers identified by linkage to cancer registries. At baseline, participants completed a 121-item FFQ including separate questions about the number of times in the past year they had consumed sugar-sweetened or artificially sweetened soft drinks. Anthropometric measurements, including waist circumference, were taken and questions about smoking, leisure-time physical activity and intake of alcoholic beverages were completed. SETTING: The Melbourne Collaborative Cohort Study (MCCS) is a prospective cohort study which recruited 41 514 men and women aged 40-69 years between 1990 and 1994. A second wave of data collection occurred in 2003-2007. SUBJECTS: Data for 35 593 participants who developed 3283 incident obesity-related cancers were included in the main analysis. RESULTS: Increasing frequency of consumption of both sugar-sweetened and artificially sweetened soft drinks was associated with greater waist circumference at baseline. For sugar-sweetened soft drinks, the hazard ratio (HR) for obesity-related cancers increased as frequency of consumption increased (HR for consumption >1/d v. 1/d v. <1/month=1·00; 95 % CI 0·79, 1·27; P-trend=0·61). CONCLUSIONS: Our results add to the justification to minimise intake of sugar-sweetened soft drinks.
OBJECTIVE: To test the hypothesis that more frequent consumption of sugar-sweetened soft drinks would be associated with increased risk of obesity-related cancers. Associations for artificially sweetened soft drinks were assessed for comparison. DESIGN: Prospective cohort study with cancers identified by linkage to cancer registries. At baseline, participants completed a 121-item FFQ including separate questions about the number of times in the past year they had consumed sugar-sweetened or artificially sweetened soft drinks. Anthropometric measurements, including waist circumference, were taken and questions about smoking, leisure-time physical activity and intake of alcoholic beverages were completed. SETTING: The Melbourne Collaborative Cohort Study (MCCS) is a prospective cohort study which recruited 41 514 men and women aged 40-69 years between 1990 and 1994. A second wave of data collection occurred in 2003-2007. SUBJECTS: Data for 35 593 participants who developed 3283 incident obesity-related cancers were included in the main analysis. RESULTS: Increasing frequency of consumption of both sugar-sweetened and artificially sweetened soft drinks was associated with greater waist circumference at baseline. For sugar-sweetened soft drinks, the hazard ratio (HR) for obesity-related cancers increased as frequency of consumption increased (HR for consumption >1/d v. 1/d v. <1/month=1·00; 95 % CI 0·79, 1·27; P-trend=0·61). CONCLUSIONS: Our results add to the justification to minimise intake of sugar-sweetened soft drinks.
Authors: Marcus D Goncalves; Changyuan Lu; Jordan Tutnauer; Travis E Hartman; Seo-Kyoung Hwang; Charles J Murphy; Chantal Pauli; Roxanne Morris; Sam Taylor; Kaitlyn Bosch; Sukjin Yang; Yumei Wang; Justin Van Riper; H Carl Lekaye; Jatin Roper; Young Kim; Qiuying Chen; Steven S Gross; Kyu Y Rhee; Lewis C Cantley; Jihye Yun Journal: Science Date: 2019-03-22 Impact factor: 47.728
Authors: Kana Wu; Edward Giovannucci; Yin Cao; Jinhee Hur; Ebunoluwa Otegbeye; Hee-Kyung Joh; Katharina Nimptsch; Kimmie Ng; Shuji Ogino; Jeffrey A Meyerhardt; Andrew T Chan; Walter C Willett Journal: Gut Date: 2021-05-06 Impact factor: 23.059
Authors: Lorena S Pacheco; Cheryl A M Anderson; James V Lacey; Edward L Giovannucci; Hector Lemus; Maria Rosario G Araneta; Dorothy D Sears; Gregory A Talavera; Maria Elena Martinez Journal: PLoS One Date: 2019-10-09 Impact factor: 3.240
Authors: Andrea Romanos-Nanclares; Walter C Willett; Bernard A Rosner; Laura C Collins; Frank B Hu; Estefania Toledo; A Heather Eliassen Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-07-21 Impact factor: 4.254