Literature DB >> 36165630

Reduced Ceftaroline Susceptibility among Invasive MRSA Infections in Children: a Clinical and Genomic Investigation.

J Chase McNeil1, Lauren M Sommer1, Jesus G Vallejo1, Kristina G Hulten1, Sheldon L Kaplan1, Anthony R Flores2.   

Abstract

Ceftaroline represents an attractive therapy option for methicillin-resistant Staphylococcus aureus (MRSA). Little data is available, however, regarding the frequency of reduced susceptibility (RS) to ceftaroline among pediatric MRSA infections. We screened invasive MRSA isolates at a tertiary children's hospital for ceftaroline RS. Ceftaroline RS occurred in 2.9% of isolates and only among health care associated infections. Ceftaroline RS isolates were more often clindamycin-resistant. Sequencing data indicated the predominance of the CC5 lineage among ceftaroline RS isolates.

Entities:  

Keywords:  MRSA; ceftaroline; health care associated; invasive; mecR; pediatric; resistance

Mesh：

Substances：

Year:  2022        PMID： 36165630      PMCID： PMC9578395          DOI： 10.1128/aac.00745-22

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  25 in total

1.  Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.

Authors:  J Chase McNeil; Lauren M Sommer; Mary Boyle; Patrick Hogan; Jesus G Vallejo; Kristina G Hultén; Anthony R Flores; Sheldon L Kaplan; Stephanie Fritz
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

2.  Identification of non-PBP2a resistance mechanisms in Staphylococcus aureus after serial passage with ceftaroline: involvement of other PBPs.

Authors:  Sushmita D Lahiri; Richard A Alm
Journal:  J Antimicrob Chemother       Date:  2016-08-05       Impact factor: 5.790

3.  Ceftaroline Resistance by Clone-Specific Polymorphism in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus.

Authors:  Hyukmin Lee; Eun-Jeong Yoon; Dokyun Kim; Jung Wook Kim; Kwang-Jun Lee; Hyun Soo Kim; Young Ree Kim; Jong Hee Shin; Jeong Hwan Shin; Kyeong Seob Shin; Young Ah Kim; Young Uh; Seok Hoon Jeong
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

4.  Genetic variation among hospital isolates of methicillin-sensitive Staphylococcus aureus: evidence for horizontal transfer of virulence genes.

Authors:  P C Moore; J A Lindsay
Journal:  J Clin Microbiol       Date:  2001-08       Impact factor: 5.948

5.  High-level ceftaroline resistance in a paediatric patient with invasive methicillin-resistant Staphylococcus aureus infection without previous ceftaroline exposure.

Authors:  Chelsea L Ferguson; Mallory C Cowart; Alejandro Jordan-Villegas; Federico Laham
Journal:  J Clin Pharm Ther       Date:  2020-11-25       Impact factor: 2.512

6.  Hospital-acquired Staphylococcus aureus infections at Texas Children's Hospital, 2001-2007.

Authors:  Kristina G Hultén; Sheldon L Kaplan; Linda B Lamberth; Katherine Slimp; Wendy A Hammerman; Maria Carrillo-Marquez; Jeffrey R Starke; James Versalovic; Edward O Mason
Journal:  Infect Control Hosp Epidemiol       Date:  2010-02       Impact factor: 3.254

7.  Evolution of Ceftaroline-Resistant Mrsa in a Child with Cystic Fibrosis Following Repeated Antibiotic Exposure.

Authors:  Christopher R Cannavino; Rodrigo E Mendes; Helio S Sader; David J Farrell; Ian A Critchley; Donald Biek; Jennifer Le; Shannon M Skochko; Ronald N Jones; John S Bradley
Journal:  Pediatr Infect Dis J       Date:  2016-07       Impact factor: 2.129

8.  SRST2: Rapid genomic surveillance for public health and hospital microbiology labs.

Authors:  Michael Inouye; Harriet Dashnow; Lesley-Ann Raven; Mark B Schultz; Bernard J Pope; Takehiro Tomita; Justin Zobel; Kathryn E Holt
Journal:  Genome Med       Date:  2014-11-20       Impact factor: 11.117

9.  Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance.

Authors:  Alexander L Greninger; Som S Chatterjee; Liana C Chan; Stephanie M Hamilton; Henry F Chambers; Charles Y Chiu
Journal:  PLoS One       Date:  2016-02-18       Impact factor: 3.240

10.  SCCmecFinder, a Web-Based Tool for Typing of Staphylococcal Cassette Chromosome mec in Staphylococcus aureus Using Whole-Genome Sequence Data.

Authors:  Hülya Kaya; Henrik Hasman; Jesper Larsen; Marc Stegger; Thor Bech Johannesen; Rosa Lundbye Allesøe; Camilla Koldbæk Lemvigh; Frank Møller Aarestrup; Ole Lund; Anders Rhod Larsen
Journal:  mSphere       Date:  2018-02-14       Impact factor: 4.389
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