Literature DB >> 27093165

Evolution of Ceftaroline-Resistant Mrsa in a Child with Cystic Fibrosis Following Repeated Antibiotic Exposure.

Christopher R Cannavino1, Rodrigo E Mendes, Helio S Sader, David J Farrell, Ian A Critchley, Donald Biek, Jennifer Le, Shannon M Skochko, Ronald N Jones, John S Bradley.   

Abstract

Ceftaroline is the first β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe a ceftaroline-resistant MRSA strain, isolated from a girl with cystic fibrosis after 22 ceftaroline treatment courses. MRSA genome sequencing documented a Tyr446Asn alteration in penicillin binding protein 2 that appeared responsible for resistance. Noncompartmental ceftaroline pharmacokinetic evaluation in our patient documented increased clearance and volume of distribution compared with adults.

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Year:  2016        PMID： 27093165     DOI： 10.1097/INF.0000000000001171

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  7 in total

1.  Pharmacokinetics of Telavancin in Adult Patients with Cystic Fibrosis during Acute Pulmonary Exacerbation.

Authors:  James M Kidd; Colleen M Sakon; Louise-Marie Oleksiuk; Jeffrey J Cies; Rebecca S Pettit; David P Nicolau; Joseph L Kuti
Journal:  Antimicrob Agents Chemother       Date:  2019-12-20       Impact factor: 5.191

2.  Reduced Ceftaroline Susceptibility among Invasive MRSA Infections in Children: a Clinical and Genomic Investigation.

Authors:  J Chase McNeil; Lauren M Sommer; Jesus G Vallejo; Kristina G Hulten; Sheldon L Kaplan; Anthony R Flores
Journal:  Antimicrob Agents Chemother       Date:  2022-09-27       Impact factor: 5.938

3.  Emergence and Within-Host Genetic Evolution of Methicillin-Resistant Staphylococcus aureus Resistant to Linezolid in a Cystic Fibrosis Patient.

Authors:  Caroline Rouard; Fabien Garnier; Jeremy Leraut; Margaux Lepainteur; Lalaina Rahajamananav; Jeanne Languepin; Marie-Cécile Ploy; Nadège Bourgeois-Nicolaos; Florence Doucet-Populaire
Journal:  Antimicrob Agents Chemother       Date:  2018-11-26       Impact factor: 5.191

Review 4.  Use of Ceftaroline Fosamil in Children: Review of Current Knowledge and its Application.

Authors:  Juwon Yim; Leah M Molloy; Jason G Newland
Journal:  Infect Dis Ther       Date:  2016-12-30

5.  Application of Next-Generation Sequencing for Characterization of Surveillance and Clinical Trial Isolates: Analysis of the Distribution of β-lactamase Resistance Genes and Lineage Background in the United States.

Authors:  Rodrigo E Mendes; Ronald N Jones; Leah N Woosley; Vincent Cattoir; Mariana Castanheira
Journal:  Open Forum Infect Dis       Date:  2019-03-15       Impact factor: 3.835

Review 6.  Antimicrobial Treatment of Staphylococcus aureus in Patients With Cystic Fibrosis.

Authors:  Susanna Esposito; Guido Pennoni; Valeria Mencarini; Nicola Palladino; Laura Peccini; Nicola Principi
Journal:  Front Pharmacol       Date:  2019-08-07       Impact factor: 5.810

7.  Carbapenems drive the collateral resistance to ceftaroline in cystic fibrosis patients with MRSA.

Authors:  Maria Celeste Varela; Melanie Roch; Agustina Taglialegna; Scott W Long; Matthew Ojeda Saavedra; Warren E Rose; James J Davis; Lucas R Hoffman; Rafael E Hernandez; Roberto R Rosato; Adriana E Rosato
Journal:  Commun Biol       Date:  2020-10-22
  7 in total

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