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Literature DB >> 3615201

Theoretical study of the sequence specificity in the covalent binding of the antitumor drug CC-1065 to DNA.

K Zakrzewska, M Randrianarivelo, B Pullman.

Abstract

A theoretical modelling is presented of the covalent adducts of the antitumor agent CC-1065 with B-DNA. The optimal complexes are obtained by energy minimisation, taking into account full structure flexibility, including the flexible rings of the ligand and DNA. The binding preference of CC-1065 with respect to base sequence is studied. The results obtained elucidate the origin of the preference for two AT base pairs on the 5'side of the modified adenine. The modifications of the DNA structure upon ligand covalent binding are discussed.

Entities: Chemical

Mesh：

Substances：

Year: 1987 PMID： 3615201 PMCID： PMC306022 DOI： 10.1093/nar/15.14.5775

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

12 in total

1. CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism.

Authors: L J Hanka; A Dietz; S A Gerpheide; S L Kuentzel; D G Martin
Journal: J Antibiot (Tokyo) Date: 1978-12 Impact factor: 2.649

2. Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity.

Authors: V L Reynolds; I J Molineux; D J Kaplan; D H Swenson; L H Hurley
Journal: Biochemistry Date: 1985-10-22 Impact factor: 3.162

Theoretical study of the sequence specificity in the covalent binding of the antitumor drug CC-1065 to DNA.

1. CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism.

2. Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity.

3. A general approach to the optimization of the conformation of ring molecules with an application to valinomycin.

4. Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity.

5. Two aspects of DNA polymorphism and microheterogeneity: molecular electrostatic potential and steric accessibility.

6. Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex.

Review 7. Molecular electrostatic potential of the nucleic acids.

8. The binding of CC-1065 to thymidine and deoxyadenosine oligonucleotides and to poly(dA).poly(dT).

9. Mechanism of interaction of CC-1065 (NSC 298223) with DNA.

10. Left-handed DNA helices.

1. Solution structure of oligonucleotides covalently linked to a psoralen derivative.