Literature DB >> 6494915

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity.

L H Hurley, V L Reynolds, D H Swenson, G L Petzold, T A Scahill.   

Abstract

Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.

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Year:  1984        PMID： 6494915     DOI： 10.1126/science.6494915

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  28 in total

1.  Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.

Authors:  R M Brosh; J K Karow; E J White; N D Shaw; I D Hickson; V A Bohr
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

2.  Mechanisms of resistance to alkylating agents.

Authors:  G Damia; M D'Incalci
Journal:  Cytotechnology       Date:  1998-09       Impact factor: 2.058

3.  Characterization of a protein recognizing minor groove binders-damaged DNA.

Authors:  G Colella; M Bonfanti; M D'Incalci; M Broggini
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

4.  Efficient priming of PCR with short oligonucleotides conjugated to a minor groove binder.

Authors:  I Afonina; M Zivarts; I Kutyavin; E Lukhtanov; H Gamper; R B Meyer
Journal:  Nucleic Acids Res       Date:  1997-07-01       Impact factor: 16.971

5.  Theoretical study of the sequence specificity in the covalent binding of the antitumor drug CC-1065 to DNA.

Authors:  K Zakrzewska; M Randrianarivelo; B Pullman
Journal:  Nucleic Acids Res       Date:  1987-07-24       Impact factor: 16.971

6.  Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1.

Authors:  L H Hurley; D R Needham-VanDevanter; C S Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

7.  Finding potential DNA-binding compounds by using molecular shape.

Authors:  P D Grootenhuis; D C Roe; P A Kollman; I D Kuntz
Journal:  J Comput Aided Mol Des       Date:  1994-12       Impact factor: 3.686

8.  (+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprinting.

Authors:  Z M Ding; R M Harshey; L H Hurley
Journal:  Nucleic Acids Res       Date:  1993-09-11       Impact factor: 16.971

9.  DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin.

Authors:  M Broggini; H M Coley; N Mongelli; E Pesenti; M D Wyatt; J A Hartley; M D'Incalci
Journal:  Nucleic Acids Res       Date:  1995-01-11       Impact factor: 16.971

10.  Phase I trial of Adozelesin using the treatment schedule of daily x5 every 3 weeks.

Authors:  B J Foster; P M LoRusso; E Poplin; M Zalupski; M Valdivieso; A Wozniak; L Flaherty; D A Kasunic; R H Earhart; L H Baker
Journal:  Invest New Drugs       Date:  1996       Impact factor: 3.850
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