Imo I Uko1,2,3, Cecil Wood4,5, Edward Nguyen6,5, Annie Huang6,5, Roberta Catania7,5, Amir A Borhani4,5, Jeanne M Horowitz4,5, Helena Gabriel4,5, Rajesh Keswani8,5, Paul Nikolaidis4,5, Frank H Miller4,5, Linda C Kelahan4,5. 1. Department of Diagnostic Radiology, McGaw Medical Center of Northwestern University, Chicago, IL, USA. imo.uko@nm.org. 2. Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL, 60611, USA. imo.uko@nm.org. 3. , Chicago, IL, 60611, USA. imo.uko@nm.org. 4. Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 5. Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL, 60611, USA. 6. Northwestern Feinberg School of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, USA. 7. Department of Diagnostic Radiology, McGaw Medical Center of Northwestern University, Chicago, IL, USA. 8. Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Abstract
PURPOSE: To determine a reliable threshold common duct diameter on CT, in combination with other ancillary CT and clinical parameters, at which the likelihood of pathology requiring further imaging or intervention is increased in post-cholecystectomy patients. METHODS: In this IRB approved retrospective study, two attending radiologists independently reviewed CT imaging for 118 post-cholecystectomy patients, who were subsequently evaluated with MRCP, ERCP, or EUS, prompted by findings on the CT and clinical status. Measurements of the common duct (CD) were obtained at the porta hepatis, distal duct, and point of maximal dilation on axial and coronal CT scans. Patients were grouped by whether they required intervention after follow-up imaging. Pertinent baseline lab values and patient demographics were reviewed. RESULTS: Of the 118 post-cholecystectomy patients, 38 patients (31%) required intervention, and 80 patients (69%) did not require intervention after follow-up imaging. For both readers, axial and coronal CD diameters were significantly higher in the 'intervention required' vs 'no intervention' groups at all locations (p value < 0.05). There was good to excellent inter-reader agreement at all locations (ICC 0.68-0.92). Pertinent baseline lab values including AST (p = 0.043), ALT (p = 0.001), alkaline phosphatase (p = 0.0001), direct bilirubin (p = 0.011), total bilirubin (p = 0.028), and WBC (p = 0.043) were significantly higher in the 'intervention required' group. CD thresholds of 8 mm yielded the highest sensitivities (76-95%), and CD thresholds of 12 mm yielded the highest specificities (65-78%). CD combined with bilirubin levels increased sensitivity and specificity, compared to using either feature alone. CONCLUSION: Dilated CD on CT combined with bilirubin levels increases the sensitivity and specificity for identifying patients needing intervention. We recommend that a post-cholecystectomy patient who presents with a CD diameter > 10 mm on CT and elevated bilirubin levels should undergo further clinical and imaging follow-up.
PURPOSE: To determine a reliable threshold common duct diameter on CT, in combination with other ancillary CT and clinical parameters, at which the likelihood of pathology requiring further imaging or intervention is increased in post-cholecystectomy patients. METHODS: In this IRB approved retrospective study, two attending radiologists independently reviewed CT imaging for 118 post-cholecystectomy patients, who were subsequently evaluated with MRCP, ERCP, or EUS, prompted by findings on the CT and clinical status. Measurements of the common duct (CD) were obtained at the porta hepatis, distal duct, and point of maximal dilation on axial and coronal CT scans. Patients were grouped by whether they required intervention after follow-up imaging. Pertinent baseline lab values and patient demographics were reviewed. RESULTS: Of the 118 post-cholecystectomy patients, 38 patients (31%) required intervention, and 80 patients (69%) did not require intervention after follow-up imaging. For both readers, axial and coronal CD diameters were significantly higher in the 'intervention required' vs 'no intervention' groups at all locations (p value < 0.05). There was good to excellent inter-reader agreement at all locations (ICC 0.68-0.92). Pertinent baseline lab values including AST (p = 0.043), ALT (p = 0.001), alkaline phosphatase (p = 0.0001), direct bilirubin (p = 0.011), total bilirubin (p = 0.028), and WBC (p = 0.043) were significantly higher in the 'intervention required' group. CD thresholds of 8 mm yielded the highest sensitivities (76-95%), and CD thresholds of 12 mm yielded the highest specificities (65-78%). CD combined with bilirubin levels increased sensitivity and specificity, compared to using either feature alone. CONCLUSION: Dilated CD on CT combined with bilirubin levels increases the sensitivity and specificity for identifying patients needing intervention. We recommend that a post-cholecystectomy patient who presents with a CD diameter > 10 mm on CT and elevated bilirubin levels should undergo further clinical and imaging follow-up.
Authors: James L Buxbaum; Syed M Abbas Fehmi; Shahnaz Sultan; Douglas S Fishman; Bashar J Qumseya; Victoria K Cortessis; Hannah Schilperoort; Lynn Kysh; Lea Matsuoka; Patrick Yachimski; Deepak Agrawal; Suryakanth R Gurudu; Laith H Jamil; Terry L Jue; Mouen A Khashab; Joanna K Law; Jeffrey K Lee; Mariam Naveed; Mandeep S Sawhney; Nirav Thosani; Julie Yang; Sachin B Wani Journal: Gastrointest Endosc Date: 2019-04-09 Impact factor: 9.427
Authors: Earl Williams; Ian Beckingham; Ghassan El Sayed; Kurinchi Gurusamy; Richard Sturgess; George Webster; Tudor Young Journal: Gut Date: 2017-01-25 Impact factor: 23.059