BACKGROUND/AIM: BAT-90 is an innovative active implantable device designed for the irradiation of unresectable tumors (e.g., liver cancer) or surgical tumor beds, based on the combination of Yttrium-90 beta-emitting microspheres and a tissue adhesive hydrogel, currently used in cardio-vascular surgery. The rationale behind BAT-90 is to localize the Yttrium-90 activity on the administration site, while minimizing its body dispersion. MATERIALS AND METHODS: The effective induction of necrosis in the target injection area was tested in a pig liver model, whereas the safety of BAT-90 was assessed and demonstrated in biocompatibility tests for acute systemic toxicity, intracutaneous reactivity, delayed hypersensitivity and subcutaneous implantation. RESULTS: BAT-90 administration induced necrosis into the target site, while the safety experiments in the treated animals highlighted results very similar to the controls. CONCLUSION: BAT-90 could be considered as a safe and innovative treatment option for inoperable solid tumors of the liver.
BACKGROUND/AIM: BAT-90 is an innovative active implantable device designed for the irradiation of unresectable tumors (e.g., liver cancer) or surgical tumor beds, based on the combination of Yttrium-90 beta-emitting microspheres and a tissue adhesive hydrogel, currently used in cardio-vascular surgery. The rationale behind BAT-90 is to localize the Yttrium-90 activity on the administration site, while minimizing its body dispersion. MATERIALS AND METHODS: The effective induction of necrosis in the target injection area was tested in a pig liver model, whereas the safety of BAT-90 was assessed and demonstrated in biocompatibility tests for acute systemic toxicity, intracutaneous reactivity, delayed hypersensitivity and subcutaneous implantation. RESULTS: BAT-90 administration induced necrosis into the target site, while the safety experiments in the treated animals highlighted results very similar to the controls. CONCLUSION: BAT-90 could be considered as a safe and innovative treatment option for inoperable solid tumors of the liver.
Authors: Nicholas Voutsinas; Safet Lekperic; Sharon Barazani; Joseph J Titano; Sherif I Heiba; Edward Kim Journal: J Nucl Med Date: 2018-08-02 Impact factor: 10.057
Authors: Mateusz J Swierz; Dawid Storman; Robert P Riemsma; Robert Wolff; Jerzy W Mitus; Michal Pedziwiatr; Jos Kleijnen; Malgorzata M Bala Journal: Cochrane Database Syst Rev Date: 2020-03-12
Authors: Ryan J DeWall; Shyam Bharat; Tomy Varghese; Meghan E Hanson; Rashmi M Agni; Mark A Kliewer Journal: Phys Med Biol Date: 2012-03-30 Impact factor: 3.609