Literature DB >> 36081314

Identification of aging-associated immunotypes and immune stability as indicators of post-vaccination immune activation.

Alper Cevirgel1,2, Sudarshan A Shetty1,2, Martijn Vos1, Nening M Nanlohy1, Lisa Beckers1, Elske Bijvank1, Nynke Rots1, Josine van Beek1, Anne-Marie Buisman1, Debbie van Baarle1,2.   

Abstract

Immunosenescence describes immune dysfunction observed in older individuals. To identify individuals at-risk for immune dysfunction, it is crucial to understand the diverse immune phenotypes and their intrinsic functional capabilities. We investigated immune cell subsets and variation in the aging population. We observed that inter-individual immune variation was associated with age and cytomegalovirus seropositivity. Based on the similarities of immune subset composition among individuals, we identified nine immunotypes that displayed different aging-associated immune signatures, which explained inter-individual variation better than age. Additionally, we correlated the immune subset composition of individuals over approximately a year as a measure of stability of immune parameters. Immune stability was significantly lower in immunotypes that contained aging-associated immune subsets and correlated with a circulating CD38 + CD4+ T follicular helper cell increase 7 days after influenza vaccination. In conclusion, immune stability is a feature of immunotypes and could be a potential indicator of post-vaccination cellular kinetics.
© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

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Year:  2022        PMID： 36081314      PMCID： PMC9577949          DOI： 10.1111/acel.13703

Source DB:  PubMed          Journal:  Aging Cell        ISSN： 1474-9718            Impact factor:   11.005


  47 in total

1.  Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.

Authors:  Chen Wang; Yi Liu; Lan T Xu; Katherine J L Jackson; Krishna M Roskin; Tho D Pham; Jonathan Laserson; Eleanor L Marshall; Katie Seo; Ji-Yeun Lee; David Furman; Daphne Koller; Cornelia L Dekker; Mark M Davis; Andrew Z Fire; Scott D Boyd
Journal:  J Immunol       Date:  2013-12-11       Impact factor: 5.422

2.  The extent of HLA-DR expression on HLA-DR(+) Tregs allows the identification of patients with clinically relevant borderline rejection.

Authors:  Matthias Schaier; Nicole Seissler; Luis Eduardo Becker; Sebastian Markus Schaefer; Edgar Schmitt; Stefan Meuer; Friederike Hug; Claudia Sommerer; Rüdiger Waldherr; Martin Zeier; Andrea Steinborn
Journal:  Transpl Int       Date:  2013-01-02       Impact factor: 3.782

3.  A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring.

Authors:  Ayelet Alpert; Yishai Pickman; Michael Leipold; Yael Rosenberg-Hasson; Xuhuai Ji; Renaud Gaujoux; Hadas Rabani; Elina Starosvetsky; Ksenya Kveler; Steven Schaffert; David Furman; Oren Caspi; Uri Rosenschein; Purvesh Khatri; Cornelia L Dekker; Holden T Maecker; Mark M Davis; Shai S Shen-Orr
Journal:  Nat Med       Date:  2019-03-06       Impact factor: 53.440

4.  Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults.

Authors:  Sara P H van den Berg; Albert Wong; Marion Hendriks; Ronald H J Jacobi; Debbie van Baarle; Josine van Beek
Journal:  Front Immunol       Date:  2018-01-29       Impact factor: 7.561

5.  Human CD8+HLA-DR+ Regulatory T Cells, Similarly to Classical CD4+Foxp3+ Cells, Suppress Immune Responses via PD-1/PD-L1 Axis.

Authors:  Andres Machicote; Santiago Belén; Placida Baz; Luis A Billordo; Leonardo Fainboim
Journal:  Front Immunol       Date:  2018-11-29       Impact factor: 7.561

6.  Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections.

Authors:  Josine van Beek; Reinier H Veenhoven; Jacob P Bruin; Renée A J van Boxtel; Marit M A de Lange; Adam Meijer; Elisabeth A M Sanders; Nynke Y Rots; Willem Luytjes
Journal:  J Infect Dis       Date:  2017-08-15       Impact factor: 5.226

Review 7.  Shaping Variation in the Human Immune System.

Authors:  Adrian Liston; Edward J Carr; Michelle A Linterman
Journal:  Trends Immunol       Date:  2016-10       Impact factor: 16.687

8.  Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.

Authors:  Valeria Orrù; Maristella Steri; Carlo Sidore; Michele Marongiu; Valentina Serra; Stefania Olla; Gabriella Sole; Sandra Lai; Mariano Dei; Antonella Mulas; Francesca Virdis; Maria Grazia Piras; Monia Lobina; Mara Marongiu; Maristella Pitzalis; Francesca Deidda; Annalisa Loizedda; Stefano Onano; Magdalena Zoledziewska; Stephen Sawcer; Marcella Devoto; Myriam Gorospe; Gonçalo R Abecasis; Matteo Floris; Mauro Pala; David Schlessinger; Edoardo Fiorillo; Francesco Cucca
Journal:  Nat Genet       Date:  2020-09-14       Impact factor: 38.330

9.  The impact of aging on regulatory T-cells.

Authors:  Johannes Fessler; Anja Ficjan; Christina Duftner; Christian Dejaco
Journal:  Front Immunol       Date:  2013-08-06       Impact factor: 7.561

Review 10.  Immunosenescence is both functional/adaptive and dysfunctional/maladaptive.

Authors:  T Fulop; A Larbi; K Hirokawa; A A Cohen; J M Witkowski
Journal:  Semin Immunopathol       Date:  2020-09-15       Impact factor: 11.759
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  1 in total

1.  Identification of aging-associated immunotypes and immune stability as indicators of post-vaccination immune activation.

Authors:  Alper Cevirgel; Sudarshan A Shetty; Martijn Vos; Nening M Nanlohy; Lisa Beckers; Elske Bijvank; Nynke Rots; Josine van Beek; Anne-Marie Buisman; Debbie van Baarle
Journal:  Aging Cell       Date:  2022-09-08       Impact factor: 11.005
  1 in total

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