| Literature DB >> 36071173 |
Shuang Deng1, Jialiang Zhang1, Jiachun Su1, Zhixiang Zuo1, Lingxing Zeng1, Kaijing Liu1,2, Yanfen Zheng1, Xudong Huang1, Ruihong Bai1, Lisha Zhuang1, Ying Ye1, Mei Li3, Ling Pan1, Junge Deng1, Guandi Wu1, Rui Li1, Shaoping Zhang1, Chen Wu4, Dongxin Lin5,6,7, Jianjun Chen8, Jian Zheng9,10.
Abstract
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and epigenetic modifications, is crucial for establishing and maintaining cell identity. The interplay between different epigenetic modifications and its contribution to transcriptional regulation remains elusive. Here, we show that METTL3-mediated RNA N6-methyladenosine (m6A) formation leads to DNA demethylation in nearby genomic loci in normal and cancer cells, which is mediated by the interaction between m6A reader FXR1 and DNA 5-methylcytosine dioxygenase TET1. Upon recognizing RNA m6A, FXR1 recruits TET1 to genomic loci to demethylate DNA, leading to reprogrammed chromatin accessibility and gene transcription. Therefore, we have characterized a regulatory mechanism of chromatin accessibility and gene transcription mediated by RNA m6A formation coupled with DNA demethylation, highlighting the importance of the crosstalk between RNA m6A and DNA modification in physiologic and pathogenic process.Entities:
Mesh：
Substances：
Year: 2022 PMID： 36071173 DOI： 10.1038/s41588-022-01173-1
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307