Literature DB >> 23498934

Transcriptional regulation and its misregulation in disease.

Tong Ihn Lee1, Richard A Young.   

Abstract

The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23498934      PMCID： PMC3640494          DOI： 10.1016/j.cell.2013.02.014

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  208 in total

1.  Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome.

Authors:  Jeroen K J Van Houdt; Beata Anna Nowakowska; Sérgio B Sousa; Barbera D C van Schaik; Eve Seuntjens; Nelson Avonce; Alejandro Sifrim; Omar A Abdul-Rahman; Marie-José H van den Boogaard; Armand Bottani; Marco Castori; Valérie Cormier-Daire; Matthew A Deardorff; Isabel Filges; Alan Fryer; Jean-Pierre Fryns; Simone Gana; Livia Garavelli; Gabriele Gillessen-Kaesbach; Bryan D Hall; Denise Horn; Danny Huylebroeck; Jakub Klapecki; Malgorzata Krajewska-Walasek; Alma Kuechler; Matthew A Lines; Saskia Maas; Kay D Macdermot; Shane McKee; Alex Magee; Stella A de Man; Yves Moreau; Fanny Morice-Picard; Ewa Obersztyn; Jacek Pilch; Elizabeth Rosser; Nora Shannon; Irene Stolte-Dijkstra; Patrick Van Dijck; Catheline Vilain; Annick Vogels; Emma Wakeling; Dagmar Wieczorek; Louise Wilson; Orsetta Zuffardi; Antoine H C van Kampen; Koenraad Devriendt; Raoul Hennekam; Joris Robert Vermeesch
Journal:  Nat Genet       Date:  2012-02-26       Impact factor: 38.330

Review 2.  The human Mediator complex: a versatile, genome-wide regulator of transcription.

Authors:  Dylan J Taatjes
Journal:  Trends Biochem Sci       Date:  2010-03-17       Impact factor: 13.807

Review 3.  NF-κB, the first quarter-century: remarkable progress and outstanding questions.

Authors:  Matthew S Hayden; Sankar Ghosh
Journal:  Genes Dev       Date:  2012-02-01       Impact factor: 11.361

4.  A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome).

Authors:  P Rump; R C Niessen; K T Verbruggen; O F Brouwer; M de Raad; R Hordijk
Journal:  Clin Genet       Date:  2011-02       Impact factor: 4.438

5.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Authors:  Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-27       Impact factor: 11.205

Review 6.  The super elongation complex (SEC) family in transcriptional control.

Authors:  Zhuojuan Luo; Chengqi Lin; Ali Shilatifard
Journal:  Nat Rev Mol Cell Biol       Date:  2012-08-16       Impact factor: 94.444

Review 7.  Non-coding RNAs: regulators of disease.

Authors:  Ryan J Taft; Ken C Pang; Timothy R Mercer; Marcel Dinger; John S Mattick
Journal:  J Pathol       Date:  2010-01       Impact factor: 7.996

Review 8.  MicroRNAs in stress signaling and human disease.

Authors:  Joshua T Mendell; Eric N Olson
Journal:  Cell       Date:  2012-03-16       Impact factor: 41.582

9.  The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene.

Authors:  Charles E Schwartz; Patrick S Tarpey; Herbert A Lubs; Alain Verloes; Melanie M May; Hiba Risheg; Michael J Friez; P Andrew Futreal; Sarah Edkins; Jon Teague; Sylvain Briault; Cindy Skinner; Astrid Bauer-Carlin; Richard J Simensen; Sumy M Joseph; Julie R Jones; Josef Gecz; Michael R Stratton; F Lucy Raymond; Roger E Stevenson
Journal:  J Med Genet       Date:  2007-03-16       Impact factor: 6.318

10.  MED12 exon 2 mutations are common in uterine leiomyomas from South African patients.

Authors:  Netta Mäkinen; Hanna-Riikka Heinonen; Shane Moore; Ian P M Tomlinson; Zephne M van der Spuy; Lauri A Aaltonen
Journal:  Oncotarget       Date:  2011-12
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  486 in total

Review 1.  RNA Structural Differentiation: Opportunities with Pattern Recognition.

Authors:  Christopher S Eubanks; Amanda E Hargrove
Journal:  Biochemistry       Date:  2018-12-18       Impact factor: 3.162

2.  The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination.

Authors:  Xiao Yao; Zhanyun Tang; Xing Fu; Jingwen Yin; Yan Liang; Chonghui Li; Huayun Li; Qing Tian; Robert G Roeder; Gang Wang
Journal:  EMBO J       Date:  2015-09-01       Impact factor: 11.598

3.  Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning.

Authors:  Babak Alipanahi; Andrew Delong; Matthew T Weirauch; Brendan J Frey
Journal:  Nat Biotechnol       Date:  2015-07-27       Impact factor: 54.908

4.  ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.

Authors:  Simon L Currie; Jedediah J Doane; Kathryn S Evans; Niraja Bhachech; Bethany J Madison; Desmond K W Lau; Lawrence P McIntosh; Jack J Skalicky; Kathleen A Clark; Barbara J Graves
Journal:  J Mol Biol       Date:  2017-07-17       Impact factor: 5.469

Review 5.  Epigenetic plasticity and the hallmarks of cancer.

Authors:  William A Flavahan; Elizabeth Gaskell; Bradley E Bernstein
Journal:  Science       Date:  2017-07-21       Impact factor: 47.728

6.  BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.

Authors:  Qiming Duan; Sarah McMahon; Priti Anand; Hirsh Shah; Sean Thomas; Hazel T Salunga; Yu Huang; Rongli Zhang; Aarathi Sahadevan; Madeleine E Lemieux; Jonathan D Brown; Deepak Srivastava; James E Bradner; Timothy A McKinsey; Saptarsi M Haldar
Journal:  Sci Transl Med       Date:  2017-05-17       Impact factor: 17.956

Review 7.  Mutations in the noncoding genome.

Authors:  Cheryl A Scacheri; Peter C Scacheri
Journal:  Curr Opin Pediatr       Date:  2015-12       Impact factor: 2.856

Review 8.  The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.

Authors:  Oleg Laptenko; David R Tong; James Manfredi; Carol Prives
Journal:  Trends Biochem Sci       Date:  2016-09-23       Impact factor: 13.807

9.  A novel strategy to dissect endogenous gene transcriptional regulation in live cells.

Authors:  Wenqing Yang; Siliang Zhang; Yi Zhang; Xin Huang
Journal:  Biochem Biophys Res Commun       Date:  2017-04-19       Impact factor: 3.575

10.  LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data.

Authors:  Changlin Wan; Wennan Chang; Yu Zhang; Fenil Shah; Xiaoyu Lu; Yong Zang; Anru Zhang; Sha Cao; Melissa L Fishel; Qin Ma; Chi Zhang
Journal:  Nucleic Acids Res       Date:  2019-10-10       Impact factor: 16.971
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