Saisai Zhao1, Wenhui Gao1, Jingsong Li2, Mengzi Sun1, Jiaxin Fang1, Li Tong1, Yue He1, Yanfang Wang1, Yuan Zhang1, Yan Xu1, Shuman Yang3, Lina Jin4. 1. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, 130021, China. 2. College of Software, Jilin University, Changchun, 130012, China. 3. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, 130021, China. shumanyang@jlu.edu.cn. 4. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, 130021, China. jinln@jlu.edu.cn.
Abstract
PURPOSE: The dietary inflammatory index (DII) is a scoring system to quantify the inflammatory effects of nutrients and foods. Inflammation may affect bone health. The purpose of this study was to explore the relationships of DII with bone mineral density (BMD) and osteoporosis. METHODS: This study involved 1023 women and 1080 men (age ≥ 50) in the US National Health and Nutrition Survey (NHANES), 2017-2018. Multivariable linear regression models were used to estimate the associations between DII and BMD. Association between DII and osteoporosis was tested with multivariable logistic regression models. RESULTS: In women, DII was negatively associated with total hip and femoral neck BMD after adjusting for covariates (P < 0.05). In men, DII was negatively associated with lumbar spine BMD (P < 0.05). DII was positively associated with osteoporosis in women (P < 0.05). The odds ratios (ORs) (95% CI) for osteoporosis associated with DII quartiles 2, 3 and 4 vs. quartile 1 were 2.95 (1.08, 8.09), 5.63 (2.87, 11.04), and 6.14(2.55, 14.78), respectively. No significant association was observed in men. CONCLUSIONS: Higher DII scores were associated with increase osteoporosis risk in women, while no association was found in men. Greater pro-inflammatory diets might be associated with lower BMD in both women and men.
PURPOSE: The dietary inflammatory index (DII) is a scoring system to quantify the inflammatory effects of nutrients and foods. Inflammation may affect bone health. The purpose of this study was to explore the relationships of DII with bone mineral density (BMD) and osteoporosis. METHODS: This study involved 1023 women and 1080 men (age ≥ 50) in the US National Health and Nutrition Survey (NHANES), 2017-2018. Multivariable linear regression models were used to estimate the associations between DII and BMD. Association between DII and osteoporosis was tested with multivariable logistic regression models. RESULTS: In women, DII was negatively associated with total hip and femoral neck BMD after adjusting for covariates (P < 0.05). In men, DII was negatively associated with lumbar spine BMD (P < 0.05). DII was positively associated with osteoporosis in women (P < 0.05). The odds ratios (ORs) (95% CI) for osteoporosis associated with DII quartiles 2, 3 and 4 vs. quartile 1 were 2.95 (1.08, 8.09), 5.63 (2.87, 11.04), and 6.14(2.55, 14.78), respectively. No significant association was observed in men. CONCLUSIONS: Higher DII scores were associated with increase osteoporosis risk in women, while no association was found in men. Greater pro-inflammatory diets might be associated with lower BMD in both women and men.
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