| Literature DB >> 35974141 |
Jari Lahti1,2, Samuli Tuominen3, Qiong Yang4, Giulio Pergola5,6, Shahzad Ahmad7, Najaf Amin7, Nicola J Armstrong8, Alexa Beiser4,9, Katharina Bey10,11, Joshua C Bis12, Eric Boerwinkle13,14, Jan Bressler13, Archie Campbell15,16, Harry Campbell17, Qiang Chen5, Janie Corley18, Simon R Cox18, Gail Davies18, Philip L De Jager19, Eske M Derks20, Jessica D Faul21, Annette L Fitzpatrick22,23,24, Alison E Fohner23,25, Ian Ford26, Myriam Fornage27, Zachary Gerring20, Hans J Grabe28,29, Francine Grodstein30,31, Vilmundur Gudnason32,33, Eleanor Simonsick34, Elizabeth G Holliday35, Peter K Joshi17,36, Eero Kajantie37,38,39, Jaakko Kaprio40,41, Pauliina Karell40, Luca Kleineidam11,42, Maria J Knol7, Nicole A Kochan43,44, John B Kwok45,46, Markus Leber47, Max Lam48,49, Teresa Lee43,44, Shuo Li4, Anu Loukola50, Tobias Luck51,52,53, Riccardo E Marioni15,54, Karen A Mather43,55, Sarah Medland56, Saira S Mirza7,57, Mike A Nalls58,59, Kwangsik Nho60,61,62, Adrienne O'Donnell4,9, Christopher Oldmeadow63, Jodie Painter56, Alison Pattie18, Simone Reppermund43,64, Shannon L Risacher60,62, Richard J Rose65, Vijay Sadashivaiah5, Markus Scholz66,67, Claudia L Satizabal9,68,69, Peter W Schofield70, Katharina E Schraut17,71, Rodney J Scott72,73, Jeannette Simino74, Albert V Smith32,33, Jennifer A Smith75,76, David J Stott77, Ida Surakka78, Alexander Teumer79, Anbupalam Thalamuthu43, Stella Trompet80, Stephen T Turner81, Sven J van der Lee7,82, Arno Villringer83,84, Uwe Völker85, Robert S Wilson86, Katharina Wittfeld28,29, Eero Vuoksimaa40, Rui Xia87, Kristine Yaffe88, Lei Yu86, Habil Zare89,90,91, Wei Zhao75, David Ames92,93, John Attia35,63, David A Bennett86, Henry Brodaty43,94, Daniel I Chasman95,96, Aaron L Goldman5, Caroline Hayward97, M Arfan Ikram7, J Wouter Jukema98, Sharon L R Kardia75, Todd Lencz99, Markus Loeffler66,67, Venkata S Mattay5,100, Aarno Palotie40,101,102, Bruce M Psaty12,103,104, Alfredo Ramirez42,47, Paul M Ridker95,96, Steffi G Riedel-Heller105, Perminder S Sachdev43,44, Andrew J Saykin60,61,62, Martin Scherer106, Peter R Schofield46,107, Stephen Sidney108, John M Starr18,109, Julian Trollor43,110, William Ulrich5, Michael Wagner11,42, David R Weir21, James F Wilson17,97, Margaret J Wright111,112, Daniel R Weinberger5,113,114,115, Stephanie Debette116,117, Johan G Eriksson118,119,120, Thomas H Mosley121, Lenore J Launer122, Cornelia M van Duijn7,123, Ian J Deary18,54, Sudha Seshadri9,68,69, Katri Räikkönen3.
Abstract
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.Entities:
Year: 2022 PMID： 35974141 DOI： 10.1038/s41380-022-01710-8
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 13.437