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Literature DB >> 35967986

Chiral Allenylcarbonyls - Underexploited Building Blocks for Complex Synthesis.

Krishna Yadavalli¹, Salvatore D Lepore¹.

Abstract

Chiral allenylcarbonyls such as allenoates remain underutilized in complex synthesis despite recent advances in synthesis methods to prepare them non-racemically. The field is now ripe for the employment of this class of allenes as building blocks to facilitate the construction of complex small-molecule compounds, such as bridged bicycles.

Entities: Chemical

Keywords: Chiral allenylcarbonyls; complex synthesis; cycloaddition; cyclobutene; diels-alder reaction; zinc

Year: 2022 PMID： 35967986 PMCID： PMC9365116 DOI： 10.2174/1570178619666211231113033

Source DB: PubMed Journal: Lett Org Chem ISSN： 1570-1786 Impact factor: 0.797

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Chiral Allenylcarbonyls - Underexploited Building Blocks for Complex Synthesis.

1. Tandem Diels-Alder/fragmentation approach to the synthesis of eleutherobin.

2. Organo-manganese η2-auxiliary directed reactions: a diastereoselective approach to 2,3-allenols.

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4. Total synthesis of (+/-)-garsubellin A.

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