Catalyst-controlled cascade synthesis of bridged bicyclic tetrahydrobenz[b]azepine-4-ones.

A catalyst-controlled cascade reaction has been developed for the synthesis of bridged bicyclic tetrahydrobenz[b]azepin-4-ones from N-arylnitrones and allenes. This method expands the accessible structural diversity of a synthetically challenging heterocyclic scaffold and tunes a catalyst-sensitive process in a new direction.