| Literature DB >> 35915169 |
Jinyoung Byun1,2, Younghun Han1,2, Yafang Li1,2,3, Jun Xia1,4, Erping Long5, Jiyeon Choi5, Xiangjun Xiao1, Meng Zhu6, Wen Zhou1, Ryan Sun7, Yohan Bossé8, Zhuoyi Song1,4, Ann Schwartz9,10, Christine Lusk9,10, Thorunn Rafnar11, Kari Stefansson11, Tongwu Zhang5, Wei Zhao5, Rowland W Pettit1, Yanhong Liu2,3, Xihao Li12, Hufeng Zhou12, Kyle M Walsh13, Ivan Gorlov1,2,3, Olga Gorlova1,2,3, Dakai Zhu1,2, Susan M Rosenberg3,4, Susan Pinney14, Joan E Bailey-Wilson15, Diptasri Mandal16, Mariza de Andrade17, Colette Gaba18, James C Willey18, Ming You19, Marshall Anderson14, John K Wiencke20, Demetrius Albanes5, Stephan Lam21, Adonina Tardon22, Chu Chen23, Gary Goodman24, Stig Bojeson25,26, Hermann Brenner27,28,29, Maria Teresa Landi5, Stephen J Chanock5, Mattias Johansson30, Thomas Muley31,32, Angela Risch31,32,33,34, H-Erich Wichmann35, Heike Bickeböller36, David C Christiani37, Gad Rennert38, Susanne Arnold39, John K Field40, Sanjay Shete7,41, Loic Le Marchand42, Olle Melander43, Hans Brunnstrom43, Geoffrey Liu44, Angeline S Andrew45, Lambertus A Kiemeney46, Hongbing Shen47, Shanbeh Zienolddiny48, Kjell Grankvist49, Mikael Johansson50, Neil Caporaso5, Angela Cox51, Yun-Chul Hong52, Jian-Min Yuan53, Philip Lazarus54, Matthew B Schabath55, Melinda C Aldrich56, Alpa Patel57, Qing Lan5, Nathaniel Rothman5, Fiona Taylor51, Linda Kachuri58, John S Witte59, Lori C Sakoda60, Margaret Spitz2, Paul Brennan30, Xihong Lin12, James McKay30, Rayjean J Hung61,62, Christopher I Amos63,64,65.
Abstract
To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.Entities:
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Year: 2022 PMID： 35915169 PMCID： PMC9373844 DOI： 10.1038/s41588-022-01115-x
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307