Literature DB >> 3586987

Oxygen-17 compounds as potential NMR T2 contrast agents: enrichment effects of H2(17)O on protein solutions and living tissues.

A L Hopkins, R G Barr.   

Abstract

The isotopic enrichment of solutions, living tissues, and organisms with oxygen-17 in the form of H2(17)O shortens their proton NMR transverse relaxation times (T2) and produces changes in NMR image intensity. The transverse relaxation rate (1/T2) was found to be linearly dependent on the H2(17)O concentration in biological solutions up to 5% enrichment. The longitudinal relaxation time (T1) is not affected by enrichment. Equal concentrations of H2(17)O do not produce the same magnitude of T2 change in all physiological environments. The reasons for these differences are discussed. The results suggest that certain oxygen-17 compounds should be explored as "contrast agents" in magnetic resonance imaging.

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Year:  1987        PMID： 3586987     DOI： 10.1002/mrm.1910040413

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  10 in total

Review 1.  NMR studies of drug metabolism and disposition.

Authors:  J D Bell; D G Gadian; N E Preece
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1990 Apr-Jun       Impact factor: 2.441

2.  Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field.

Authors:  Xiao-Hong Zhu; Yi Zhang; Run-Xia Tian; Hao Lei; Nanyin Zhang; Xiaoliang Zhang; Hellmut Merkle; Kamil Ugurbil; Wei Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-19       Impact factor: 11.205

Review 3.  Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields.

Authors:  Ali Gordji-Nejad; Klaus Möllenhoff; Ana Maria Oros-Peusquens; Deepu R Pillai; Nadim Jon Shah
Journal:  MAGMA       Date:  2013-12-15       Impact factor: 2.310

Review 4.  In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field.

Authors:  Xiao-Hong Zhu; Wei Chen
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2011-04-23       Impact factor: 9.795

5.  Visualization of water movement in the living rabbit eye.

Authors:  H M Cheng; K K Kwong; J Xiong; B T Woods
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1992       Impact factor: 3.117

6.  Imaging of H217O distribution in the brain of a live rat by using proton-detected 17O MRI.

Authors:  I Ronen; H Merkle; K Ugurbil; G Navon
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

Review 7.  Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by Mitochondria.

Authors:  Xiao-Hong Zhu; Fei Du; Nanyin Zhang; Yi Zhang; Hao Lei; Xiaoliang Zhang; Hongyan Qiao; Kamil Ugurbil; Wei Chen
Journal:  Methods Mol Biol       Date:  2009

8.  Dynamic Diffusion Magnetic Resonance Imaging of Infarct Formation and Peri-infarct Spreading Depression after Middle Cerebral Artery Occlusion (MCAO) in macacca fasicularis.

Authors:  Helen E D'Arceuil; Alex de Crespigny
Journal:  Open Neuroimag J       Date:  2011-11-18

9.  Quantification of H217O by 1H-MR imaging at 3 T: a feasibility study.

Authors:  Luis Martí-Bonmatí; Alejandro Rodríguez-Ortega; Amadeo Ten-Esteve; Ángel Alberich-Bayarri; Bernardo Celda; Eduardo Ferrer
Journal:  Eur Radiol Exp       Date:  2021-12-29

Review 10.  In vivo Human MR Spectroscopy Using a Clinical Scanner: Development, Applications, and Future Prospects.

Authors:  Moyoko Tomiyasu; Masafumi Harada
Journal:  Magn Reson Med Sci       Date:  2022-02-15       Impact factor: 2.760
  10 in total

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