Literature DB >> 2200682

NMR studies of drug metabolism and disposition.

J D Bell1, D G Gadian, N E Preece.   

Abstract

The ways in which NMR is being used in vivo to study drug metabolism and disposition are reviewed. We also assess the role of this technique as a non-invasive method for monitoring the fate of drugs in human and animals, and for providing information about pharmacology and toxicity.

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Year:  1990        PMID： 2200682     DOI： 10.1007/BF03190195

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  46 in total

1.  Determination of halothane distribution in the rat head using 19F NMR technique.

Authors:  A M Wyrwicz; C B Conboy
Journal:  Magn Reson Med       Date:  1989-02       Impact factor: 4.668

2.  A deuterium surface coil NMR study of the metabolism of D-methionine in the liver of the anesthetized rat.

Authors:  R E London; S A Gabel
Journal:  Biochemistry       Date:  1988-10-04       Impact factor: 3.162

Review 3.  Applications of NMR spectroscopy to biological systems.

Authors:  N E MacKenzie; P R Gooley
Journal:  Med Res Rev       Date:  1988 Jan-Mar       Impact factor: 12.944

4.  Spin-echo fluorine magnetic resonance imaging at 2 T: in vivo spatial distribution of halothane in the rabbit head.

Authors:  W M Chew; M E Moseley; P A Mills; D Sessler; R González-Méndez; T L James; L Litt
Journal:  Magn Reson Imaging       Date:  1987       Impact factor: 2.546

5.  Identification by proton NMR of N-(hydroxymethyl)-N-methylformamide as the major urinary metabolite of N,N-dimethylformamide in mice.

Authors:  P Kestell; M H Gill; M D Threadgill; A Gescher; O W Howarth; E H Curzon
Journal:  Life Sci       Date:  1986-02-24       Impact factor: 5.037

Review 6.  Fluorinated substrate analogs: routes of metabolism and selective toxicity.

Authors:  C Walsh
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1983

7.  Noninvasive evaluation of effects of an aldose reductase inhibitor in rat brain by 19F FDG NMR spectroscopy.

Authors:  T Nakada; I L Kwee
Journal:  Magn Reson Med       Date:  1987-04       Impact factor: 4.668

8.  Assessment of human liver metabolism by phosphorus-31 magnetic resonance spectroscopy.

Authors:  R D Oberhaensli; G J Galloway; D J Taylor; P J Bore; G K Radda
Journal:  Br J Radiol       Date:  1986-07       Impact factor: 3.039

9.  Oxygen-17 compounds as potential NMR T2 contrast agents: enrichment effects of H2(17)O on protein solutions and living tissues.

Authors:  A L Hopkins; R G Barr
Journal:  Magn Reson Med       Date:  1987-04       Impact factor: 4.668

10.  1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.

Authors:  D L Rothman; K L Behar; H P Hetherington; J A den Hollander; M R Bendall; O A Petroff; R G Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205
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  1 in total

1.  Mimicking of Phase I Metabolism Reactions of Molindone by HLM and Photocatalytic Methods with the Use of UHPLC-MS/MS.

Authors:  Maciej Gawlik; Vladimir Savic; Milos Jovanovic; Robert Skibiński
Journal:  Molecules       Date:  2020-03-17       Impact factor: 4.411
  1 in total

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