Alice S Ryan1, Guoyan Li2. 1. VA Research Service, VA Maryland Health Care System, Baltimore, Maryland 21201, USA. 2. Department of Medicine, Division of Geriatric and Palliative Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Abstract
Context: Adiponectin is an adipokine mainly secreted by adipocytes that regulates the metabolism of lipids and glucose. Liver receptor homolog-1 (LRH-1), also named NR5A2, is a nuclear receptor that regulates lipid metabolism and homeostasis. Objective: The purpose of this study was to compare adiponectin and LRH-1 messenger RNA (mRNA) expression in adipose tissue and LRH-1 expression in skeletal muscle between men and women at baseline and to study the effects of aerobic exercise (AEX) training or weight loss (WL) on their expression. Methods: This hospital and university setting study included 62 overweight and obese men (n = 23) and women (n = 39) older than 45 years, of whom 41 completed 6 months of WL (n = 21) or AEX (n = 20). Outcomes included abdominal and gluteal adipose tissue and skeletal muscle gene expression. Results: Adiponectin and LRH-1 mRNA expression in adipose tissue and LRH-1 mRNA expression in skeletal muscle is higher in women than in men (P < .05). Adiponectin mRNA expression in gluteal and abdominal adipose tissue did not change significantly after AEX or WL. LRH-1 mRNA expression increased both in adipose tissue and skeletal muscle after AEX (P < .05) and the change in muscle LRH-1 was different between the groups (P < .05). Adiponectin was positively correlated to LRH-1 in adipose tissue (P < .001). The change in maximal oxygen consumption related to the change in LRH-1 mRNA (r = 0.43; P = .01). Conclusion: LRH-1, as a nuclear reporter, may activate adiponectin mRNA expression in adipose tissue and increases after AEX. Published by Oxford University Press on behalf of the Endocrine Society 2022.
Context: Adiponectin is an adipokine mainly secreted by adipocytes that regulates the metabolism of lipids and glucose. Liver receptor homolog-1 (LRH-1), also named NR5A2, is a nuclear receptor that regulates lipid metabolism and homeostasis. Objective: The purpose of this study was to compare adiponectin and LRH-1 messenger RNA (mRNA) expression in adipose tissue and LRH-1 expression in skeletal muscle between men and women at baseline and to study the effects of aerobic exercise (AEX) training or weight loss (WL) on their expression. Methods: This hospital and university setting study included 62 overweight and obese men (n = 23) and women (n = 39) older than 45 years, of whom 41 completed 6 months of WL (n = 21) or AEX (n = 20). Outcomes included abdominal and gluteal adipose tissue and skeletal muscle gene expression. Results: Adiponectin and LRH-1 mRNA expression in adipose tissue and LRH-1 mRNA expression in skeletal muscle is higher in women than in men (P < .05). Adiponectin mRNA expression in gluteal and abdominal adipose tissue did not change significantly after AEX or WL. LRH-1 mRNA expression increased both in adipose tissue and skeletal muscle after AEX (P < .05) and the change in muscle LRH-1 was different between the groups (P < .05). Adiponectin was positively correlated to LRH-1 in adipose tissue (P < .001). The change in maximal oxygen consumption related to the change in LRH-1 mRNA (r = 0.43; P = .01). Conclusion: LRH-1, as a nuclear reporter, may activate adiponectin mRNA expression in adipose tissue and increases after AEX. Published by Oxford University Press on behalf of the Endocrine Society 2022.
Authors: Maaike H Oosterveer; Chikage Mataki; Hiroyasu Yamamoto; Taoufiq Harach; Norman Moullan; Theo H van Dijk; Eduard Ayuso; Fatima Bosch; Catherine Postic; Albert K Groen; Johan Auwerx; Kristina Schoonjans Journal: J Clin Invest Date: 2012-07-09 Impact factor: 14.808
Authors: Jan Polak; Eva Klimcakova; Cedric Moro; Nathalie Viguerie; Michel Berlan; Jindriska Hejnova; Blanka Richterova; Ivan Kraus; Dominique Langin; Vladimir Stich Journal: Metabolism Date: 2006-10 Impact factor: 8.694
Authors: Alice H Lichtenstein; Lawrence J Appel; Michael Brands; Mercedes Carnethon; Stephen Daniels; Harold A Franch; Barry Franklin; Penny Kris-Etherton; William S Harris; Barbara Howard; Njeri Karanja; Michael Lefevre; Lawrence Rudel; Frank Sacks; Linda Van Horn; Mary Winston; Judith Wylie-Rosett Journal: Arterioscler Thromb Vasc Biol Date: 2006-10 Impact factor: 8.311
Authors: M Cnop; P J Havel; K M Utzschneider; D B Carr; M K Sinha; E J Boyko; B M Retzlaff; R H Knopp; J D Brunzell; S E Kahn Journal: Diabetologia Date: 2003-04-10 Impact factor: 10.122
Authors: Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa Journal: Biochem Biophys Res Commun Date: 1999-04-02 Impact factor: 3.575
Authors: Per Sjögren; Justo Sierra-Johnson; Lena V Kallings; Tommy Cederholm; Maria Kolak; Mats Halldin; Kerstin Brismar; Ulf de Faire; Mai-Lis Hellénius; Rachel M Fisher Journal: Lipids Health Dis Date: 2012-06-21 Impact factor: 3.876