| Literature DB >> 35852682 |
T G Borovskaya1, V A Grigor'eva2, Yu A Shchemerova2, E A Bokhan2, A V Vychuzhanina2, S I Kamalova2, V E Goldberg3.
Abstract
Delayed gonadotoxic effects were revealed in outbred male sexually mature rats (SD) after exposure to paclitaxel in the prepubertal period, and the possibility of their correction with p-tyrosol was shown. It was found, that administration of paclitaxel does not inhibit the ability of animals to conceive, but impairs the reserve capacity of the testicular tissue. In intact female rats crossed with male rats receiving paclitaxel, increased post-implantation fetal death was observed. Combined administration of paclitaxel and p-tyrosol alleviated the delayed effects of the cytostatic treatment on the prepubertal testis.Entities:
Keywords: p-tyrosol; paclitaxel; prepubertal rats; testis; toxicity
Mesh：
Substances：
Year: 2022 PMID： 35852682 DOI： 10.1007/s10517-022-05546-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.737