Literature DB >> 26515175

Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure.

A M Dygai1, A V Chaikovskii2, V V Zhdanov1, G N Zyuz'kov1, L A Stavrova1, V V Udut1, L A Miroshnichenko1, E V Simanina1, T G Borovskaya1, M E Poluektova1.   

Abstract

A decrease in the total number of sperm cells and reduction of spermatogonium population were observed upon cytostatic damage of spermatogenous tissue caused by single paclitaxel administration. It was established that the paclitaxel-induced damage to the testicular tissue is underlain by reduction of its regenerative potential consisting in depletion of regional precursor pool. Changes in functional activity of progenitor cells were caused not only by direct action of paclitaxel, but also by suppression of the secretory function of the tissue microenvironment.

Entities:  

Keywords:  Sertoli cells; paclitaxel; progenitor cells; regenerative medicine; spermatogenous tissue

Mesh：

Substances：

Year:  2015        PMID： 26515175     DOI： 10.1007/s10517-015-3064-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells.

Authors:  T G Borovskaya; V A Grigor'eva; Yu A Shchemerova; S I Kamalova; A V Vychuzhanina; N A Krivova; O B Zaeva; V E Goldberg; A M Dygai
Journal:  Bull Exp Biol Med       Date:  2022-03-30       Impact factor: 0.804

2.  Delayed Consequences of the Toxic Effect of Paclitaxel on the Testes of Prepubertal Rats and Their Correction with p-Tyrosol.

Authors:  T G Borovskaya; V A Grigor'eva; Yu A Shchemerova; E A Bokhan; A V Vychuzhanina; S I Kamalova; V E Goldberg
Journal:  Bull Exp Biol Med       Date:  2022-07-19       Impact factor: 0.737

3.  Melatonin ameliorates paclitaxel-induced mice spermatogenesis and fertility defects.

Authors:  ZhiXin Wang; Zi Teng; ZeLin Wang; Zhan Song; Peng Zhu; Ning Li; YuSheng Zhang; XueXia Liu; FuJun Liu
Journal:  J Cell Mol Med       Date:  2022-01-09       Impact factor: 5.310
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.