| Literature DB >> 35842068 |
Mark A Faghy1, Ross Arena2, Abraham Samuel Babu3, Jeffrey W Christle4, Susan Marzolini5, Dejana Popovic6, Amber Vermeesch7, Nicolaas P Pronk8, Lee Stoner9, Andy Smith10.
Abstract
We have been amid unhealthy living and related chronic disease pandemics for several decades. These longstanding crises have troublingly synergized with the coronavirus disease 2019 (COVID-19) pandemic. The need to establish research priorities in response to COVID-19 can be used to address broad health and wellbeing, social and economic impacts for the future is emerging. Accordingly, this paper sets out a series of research priorities that could inform interdisciplinary collaboration between clinical sciences, public health, business, technology, economics, healthcare providers, and the exercise science/sports medicine communities, among others. A five-step methodology was used to generate and evaluate the research priorities with a focus on broad health and well-being impacts. The methodology was deployed by an international and interdisciplinary team from the Healthy Living for Pandemic Event Protection (HL- PIVOT) network. This team were all engaged in responding to the Pandemic either on the 'front-line' and/or in leadership positions ensuring the currency and authenticity of the process. Eight research priorities were identified clustered into two groups: i) Societal & Environmental, and ii) Clinical. Our eight research priorities are presented with insight from previously published research priorities from other groups.Entities:
Keywords: COVID-19; Collaboration exercise medicine; Health and wellbeing; Pandemic legacy; Prevention; Priorities; Research
Mesh:
Year: 2022 PMID: 35842068 PMCID: PMC9278010 DOI: 10.1016/j.pcad.2022.07.001
Source DB: PubMed Journal: Prog Cardiovasc Dis ISSN: 0033-0620 Impact factor: 11.278
Fig. 1The five step methodology adopted to reach consensus in the development of subsequent research priorities.
Template provided to all respondents from the initial call to ascertain details important to research priority development.
| Submission question | Commentary |
|---|---|
| What is your Profession? | This was asked to ensure that we had representatives from a variety of healthcare specialities and organisations. |
| State the research question that you think it is most important that Exercise Science and/or Sports Medicine addresses post-pandemic. Please make sure that your response is framed as a question | This was the most important question being designed to get a clear response. |
| What research methodology would you propose to investigate the question you pose above? | This question was asked so that we could classify the proposed methodologies as i) qualitative, ii) quantitative or iii) mixed methods and to enable us to report not only the research questions but also the proposed methodologies. |
| How was your research question shaped by your experience on the front line of the Pandemic? | This item was designed to enable us to link the research priorities to professional practice. |
| How would addressing your research question help us in the next Pandemic? | COVID-19 is not the first Pandemic, and it will not be the last. Therefore, it is important that Post Pandemic research priorities help us prepare for the next crisis. |
| Why is your research question one that could only be asked post-pandemic? | The purpose of this consensus statement was to identify post-pandemic research priorities that could not or would not have been addressed before COVID-19 Pandemic. |
| Is there an international dimension to your question? | As by definition, a pandemic is a global health emergency so some of the research questions that emerge from it need to have an international dimension. |
| Is there an interdisciplinary dimension to your research question or proposed methodology? If so, can you explain it? | The need for interdisciplinary research has been recognised. |
| Is there a social or contributive justice aspect to your research question? If so, please reflect upon it here. | Scientific and medical research does not take place in a cultural or political vacuum and this item was included to locate the research in a societal context. |
| If there are any existing publications that support giving priority to your research question, please cite up to 2 of them below. | This item helped locate the proposed research priorities within the existing literature. |
| Finally, and potentially most importantly please use the space below to make the case that your research question should be a global post-pandemic research priority. You can do so in any way you wish including summarising the points you have made above or introducing new arguments. | This open question was designed to ensure that responders had every opportunity to unpack their thinking. |
Fig. 2A word cloud developed using author submissions from the initial stages of the methodology.
Summary of published post pandemic and COVID 19 related research priorities.
| References | Methodology | Research priorities | Evaluation |
|---|---|---|---|
| Carson, G., Long-COVID Forum Group., (2021)., Research priorities for Long Covid: refined through an international multi-stakeholder forum., | Public forum to increase understanding of Long-COVID and define research priorities for funders and researchers to take forward. | The need to establish Global patient voices. Broader knowledge of Long-COVID and the implications for mild/asymptomatic and younger groups Global and country-specific responses. Reflecting on Chikungunya Psychological Health Consensus between ongoing Long-COVID research to understand the aetiology, identify treatments and develop holistic care pathway for rehabilitation, interventions, and social support systems. | The paper here sets out a list of priorities that have been informed and developed in conjunction with patient groups. The paper identifies several important areas for consideration in research and highlights the need for bespoke multi-disciplinary approaches to support patients. Whilst the paper acknowledges the complexity of the challenge, there is little insight offered from patients in the approaches that are needed and could be taken to inform the design and development of future research projects. There are limited details relating to the study methodology and how the research priorities were derived. |
| UK Parliamentary Office of Science and Technology (POST) COVID-19 Areas of Research Interest | POST sent an online survey to members of its COVID-19 outbreak expert database and received 1100 responses. The survey included a question about what experts' most important concerns were relating to the impact of the COVID-19 outbreak beyond the next 9 months (long-term concerns). | Lessons learned from the COVID-19 outbreak National and international preparedness for future pandemics Economic recovery and growth Social, economic and health inequalities Changes to viability and functioning of businesses Sustainable economic recovery and policies to address climate change International economy and global trade Supply chains and shortages of goods and labour Resilience of the economy to future shocks Communications strategy for public health messages Resilience of society to future shocks Changes to the availability of work, working conditions and types of employment Surveillance, data collection and data privacy Long-term mental health effects of COVID-19 Changes to the role of education and the future of learning Population mental health and well-being Long-term physical health effects COVID-19 Strategy for vaccine development, production, and distribution Future sustainability of the NHS and social care system Changes to crime, policing and the criminal justice system | POST as part of the UK Parliament sets out a comprehensive list of research priorities that are capable of directing future research and policy level activity and is cognisant of the broad and widespread impact of COVID-19. There is little detail relating to the interconnectedness of these priorities, which will be important in the design and delivery of future work in this area and resulting actions. It is encouraging that POST includes details relating to post-COVID preparedness for future pandemics, developing the sentiment by health researchers globally that COVID-19 will not be the last global pandemic. Seeing the learning from this work come to fruition is of great interest. The research priorities highlight the broad and international need for COVID-19 research and the report provides guidance on how this information will be used by UK parliament and by researchers with an interest in COVID-19 research. At the heart of this and what should be included here is the need to establish international collaboration between patients, clinical, academic, and governmental agencies to unify approaches and address the global impacts that have already and will continue to prevail in the COVID-19 legacy. |
| World Health Organisation: Research and Development (R&D) Blueprint and COVID-19 | The World Health Organisation and its R&D Blueprint is a global strategy that allows the rapid activation of research and development activities during epidemics and pandemics. It aims to fast-track the availability of effective tests, vaccines, medicines, and research that can be used to save lives and avert large scale crises. | The themes of activity are consolidated into key areas that are served by several established international working groups. Broadly these can be defined into the following areas: Vaccines Therapeutics Diagnostics Ethics Social Science Clinical Management IPC including HWs Epidemiological Studies Addressing public health concerns Research with fair and equitable access Investment in research priorities with a long-term outlook Develop approaches that are broad in scope and maintain longitudinal focus. | The priorities set out a broad and international collaborative focus that can be utilised and adopted into practice by researchers, research funders and government agencies globally. The blueprint sets out a plan of action that can be broadly interpreted and tailored to suit the needs and or approaches to be taken by a global audience but little insight into the approaches taken as a collective international response is offered. The areas of activity are covered by many established international working groups but there is little detail in their membership and how these were used in the development of the recommendations for future research. |
| O'Connor, D, B., et al | The British Psychological Society convened a core group of nine experts who met regularly over 4 weeks to develop the research priorities. The experts represented broad areas of the psychology discipline and were assisted by a wider advisory group of psychological scientists from a range of UK higher education institutions. The input was also received from international experts. | Groups, cohesion, and conflict: How does collective identification impact social responsibility and adherence to anti-pandemic measures? How can we nurture the development and persistence of mutual aid and pro-social behaviours? What is the relationship between group membership, connectedness, and well-being? Under what conditions do unity and social solidarity give way to intergroup division and social conflict? What is the impact of remote and flexible working arrangements on employee health, mental wellbeing, teamwork, performance, organizational productivity, and colleague/client relationships? What is the impact of social distancing in the workplace on employee health, mental well-being? teamwork, performance, organizational productivity, and colleague/client relationships? How can organizational resilience be developed to deal with the impact of COVID-19 whilst supporting employees and protecting jobs? How will the COVID-19 pandemic affect children's development? How will the COVID-19 pandemic affect family functioning? How do school closures influence children's educational progress and well-being? What kinds of support improve long-term outcomes for children and young people? How can support services be effectively delivered to vulnerable children and young people, families, and schools? What are the immediate and longer-term consequences of COVID-19 for mental health outcomes? What changes in approaches resulting from the pandemic need to be harnessed for the future? Does COVID-19 have neurological effects on the brain with consequences for mental health? What are the psychobiological impacts of the COVID-19 pandemic on physical and mental health? How do we best apply existing theories and tools to promote sustained behaviour change among? policymakers, key workers, and the public/patients? How do we develop new theories and tools to promote sustained behaviour change? | O'Connor et al and the British Psychological Society set out a series of research priorities that broadly cover the discipline areas of psychology developed using a detailed methodological approach to support helping society recover. The areas of focus are closely linked to the priorities outlined by other groups and aligned to the expertise of the BPS but the detail of how the psychological priorities and non-psychological organisations/disciplines are not well established/detailed. The importance of the priorities that have been detailed will address some of the biggest global impacts of COVID-19, especially the mental health impacts of patients and the public are acknowledged here but greater consideration and detail of how this will be incorporated into developing resultant support mechanisms that are multi-disciplinary and collaborative are needed. The inclusion of behavioural approaches is important in the design and delivery of immediate support for the patient and broader society. It is acknowledged that pre-COVID health status was an effective strategy to prevent serious COVID-19 related illness and with future learning and pandemic preparedness, the role of behaviour change to promote improved health status and subsequent outcomes is pivotal to prevent a repeat of the COVID-19 is pivotal. Acknowledging this and establishing collaborative links with health scientists in clinical and non-clinical settings to develop efficacious health promotion strategies that can be championed by governments globally could lead to profound impacts in global health and wellbeing alongside broad societal and economical areas. |
| Holmes., E, A., et al. (2020)., Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science., The Lancet Psychiatry., 7(6), 547–560. | The research priorities were established in a three-part process: An interdisciplinary group of world‑leading experts ( Thematic analysis was conducted on data from an online survey ( Two questions were asked on Ipsos MORI's online Omnibus survey to collect further data on people's concerns about the effect of COVID-19 on mental wellbeing. One thousand and ninety-nine interviews were completed using a representative sample from the UK. | The research priorities highlighted are categorised as either immediate or longer-term strategic priorities. Mental health consequences of COVID-19 and associated lockdowns in the general population and for vulnerable groups and how these can be mitigated? Determine ways of signposting and delivering mental health services for vulnerable groups. Identify and evaluate outreach methods to support those at risk of abuse within the home. Ascertain evidence-based interventions that can be repurposed for COVID-19. Identify gaps requiring bespoke interventions to boost wellbeing and reduce mental health issues. Provide interventions to promote mental wellbeing in front-line healthcare workers exposed to stress and trauma that can be delivered now and at scale. Design bespoke approaches for population-level interventions targeted at the prevention and treatment of mental health symptoms and boosting coping and resilience. Develop interventions from experimental and social sciences to help mental health. Assess the effectiveness of arts-based and life-skills based interventions and other generative activities including exercise outdoors. What is the effect of media consumption about COVID-19 in traditional and social media on mental health, and how can wellbeing be promoted? Understand the role of repeated media consumption in amplifying distress and anxiety, and optimal patterns of consumption for wellbeing Develop strategies and mitigate over-exposure to media, including encouraging diverse populations to stay informed by authoritative sources. Inform media policy on pandemic reporting. Mitigate individuals' risk of misinformation. Understand and harness the uses of traditional media, online gaming, and social media platforms. Promoting successful adherence to behavioural advice about COVID-19 and enabling mental wellbeing and minimizing distress? Understand how health messaging can optimise behaviour change and reduce unintended mental health issues. Track perceptions of and responses to public health messages to allow iterative improvements, informed by mental health science. Synthesise an evidence base of lessons learned for future pandemics. Understand the facilitators and barriers for activities that promote good mental health. Promote people's care and concern for others, fostering collective solidarity and altruism. Neuroscience: effects of the virus on brain health and mental health Build a neuropsychological database of UK coronavirus disease 2019 cases that is inclusive. Expand facilities for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected tissue handling. Understand how SARS-CoV-2 might enter and propagate through the brain and how the immune response to SARS-CoV-2 infection contributes to mental health and neurological symptoms. Investigate the long-term relationship between SARS-CoV-2 infection and post-infective fatigue or depressive syndromes. Validate clinical biomarkers of SARS-CoV-2 brain infection using detailed methods. Develop interventions to interrupt or prevent the biological effects of SARS-CoV-2 on brain function and mental health. | The position paper from Holmes et al. is poignant and sets out a series of research priorities that address the mental health issues being felt globally during the COVID-19 pandemic. The iterative process used in determining the established priorities is rigorous and whilst there is a crossover to the paper by O'Connor et al., here the short and long-term considerations to guide research are outlined. The use of existing intervention approaches that can be repurposed and scaled to support the COVID-19 pandemic are suggested alongside the need to identify knowledge gaps that require bespoke approaches. The mental and physical challenges of the COVID-19 pandemic and its impacts are broad and have undoubtedly propagated mental health issues that were previously not widely recognised or as prominent (e.g., isolation and confinements imposed by lockdowns and social distancing, remote working and reduced social interaction and sustained uncertainty around transmission and emerging variants). These issues present a global challenge across the life span that must be addressed with bespoke COVID-19 approaches. The development of interventions that consider the knowledge and expertise of the social sciences will be imperative to addressing the mental health impacts of the pandemic. The paper highlights the role and importance of physical activity and being outdoors which are widely used but confounded by adherence, accessibility, and scalability. This creates the opportunity for the social and physical sciences to work collaboratively to create and deliver impactful and scalable intervention approaches to support patients in the post-COVID phase and more broadly the general public who have been impacted by the pandemic. There is a clear role for governing bodies and specific organisations to take responsibility for driving effective cross-disciplinary working and collaboration to address the global need. |
| Tong, A., et al., (2021)., Research priorities for COVID-19 sensor technology., Nature Biotechnology., 39, pages144–147 (2021) | Forty-three participants completed an online survey. Participants included patients with COVID-19, family members, members of the public, scientists, engineers, health professionals, policymakers, industry representatives and research funders. Research statements were ranked in order of priority using a 9-point Likert scale. Statements that achieved a median of >7 were discussed at an online consensus workshop ( | The research priorities were summarized in four themes: Firstly, enabling efficient clinical decision-making and preventing delays in access to treatment, protecting overstretched healthcare resources and providing prognostic information that can be used to inform patient care. Secondly, minimizing disruption to society and facilitating a return to pre-pandemic life, to reduce stigma and isolation associated with COVID-19. Thirdly, protecting communities and highlighting the need for sensor technologies that can trigger contact tracing, establish safe environments, safeguard the vulnerable, gauge individual susceptibility to COVID-19, and mitigate the risk for healthcare workers. Finally, preparedness for the next phase(s) of the pandemic’ requires sensor technology to be relevant and responsive to the development of vaccines and patient support pathways over the longer term. | The role of sensor technologies in healthcare settings has dramatically increased this century and pioneering technologies exist broadly across healthcare services. The COVID-19 pandemic has further highlighted the role and the importance of integrating sensor technology to support patients and optimise healthcare provision is highlighted in the resulting research priorities in this paper. The methodology used a broad range of participants from patients to clinical specialists and policymakers to research funders. An important omission is a representation from primary care settings (i.e., general practitioners, physiotherapists, physical therapists, and counsellors) who are likely to be at the forefront of the delivery of the long-standing issues associated with COVID-19 e.g., community-based support pathways. What is apparent if to address the complexity and global need is multi-disciplinary collaborations that consider and includes all stakeholders. The idea of addressing the next phases of the pandemic is presented but little detail is provided to highlight what this includes. The current global picture presents a concerning and longstanding issue that must address sustained transmission, new variants, and mutation of COVID-19 and the legacy impacts for patients with profound symptoms profiles post COVID-19. On this last point, sensor technology and the associated innovation could provide useful tools and resources that can be integrated into COVID-19 specific support mechanisms and rehabilitation approaches to restore the functional status and quality of life. |
| Norton., A., et al., (2020)., The remaining unknowns: a mixed methods study of the current and global health research priorities for COVID-19., BMJ Global Health., 2020;5: e003306. | A mixed-method multi-stage process was used in the development of the subsequent research priorities. An online survey ( Virtual workshops were held to seek comment and discussion on the survey findings and to discuss current priorities and unmet research areas priority framework. Ten open access ( | Existing priorities now requiring greater research emphasis: Infection recurrence: Understanding infections and outcomes in vulnerable populations including children, persons living with disabilities, ethnic groups Relationship between repeated viral exposure and disease severity in frontline workers The effects of the disease on pregnant women Effective use of personal protective equipment for frontline healthcare workers (emphasis on nurses) Health systems research and strengthening to mitigate the impact of COVID-19 on capacity The understanding zoonotic leap between humans and animals The impact of redirecting resources and public health interventions toward COVID-19 on other disease burdens Adherence to and trust in public health interventions such as quarantine and social distancing Evaluation of public health interventions in varied settings Public health messaging and addressing myths and mistrust Engaging relevant stakeholders (including religious leaders) in research to enhance community sensitisation, adherence to public health measures, detection, and surveillance Effective and feasible ways of community engagement during lockdowns and social distancing. Virus natural history, transmission, and diagnostics Epidemiological studies Clinical management Candidate therapeutics R&D Candidate vaccines R&D Ethical considerations for research Social sciences in the outbreak response Infection prevention and control The environmental impact of the response to COVID-19 Preparing for the next pandemic Cross-cutting | The mapping of research priorities against the established World Health Organisation COVID-19 Roadmap provides an update and extension to existing work by international agencies whilst also providing an opportunity for stakeholders internationally to provide global insight and representation to the challenges being faced in the short and longer-term that is socially and economically representative. Detailed mixed methods approach specifically the opportunities to provide qualitative entries in the survey and subsequent workshops, provide meaningful data that is captured in the decision-making process and provides The new research priorities presented in |
Fig. 3A sedond word cloud developed following refinement of the research questions and priority areas.
Fig. 4Ranking of importance by HL-Pivot netowrk members between the two theme areas of societal and environmental and clinical research priorities.
Research priorities that were put forward but not included in the resulting priority areas following the consensus process.
| 1 | The importance of considering training and education within (i) healthy living concepts and self-care in health professionals, and (ii) how health professionals incorporate patient education and health promotion. |
| 2 | The use of online and digital platforms that can be used to promote and deliver physical activity and the impact upon human behaviour. |
| 3 | Investigate the impact of physical activity and exercise on Covid-19 cardiorespiratory sequelae, among other repercussions. |
| 4 | Screen time in children (and possibly adults) and the effect on physical and emotional health |
| 5 | What impact does COVID-19 infection have on cardiovascular and pulmonary function after recovery? |
| 6 | Energy Conservation Techniques to manage Symptoms (e.g., Fatigue, Dyspnoea due to Lung Fibrosis) of long term COVID-19. |
| 7 | How can we use lessons from the pandemic to emphasize prevention (i.e., lifestyle medicine)? |
| 8 | The impact of physical activity-based rehabilitation in recovery from long COVID. |
| 9 | Incorporation of exercise and physical activity into the treatment plans for all patients with chronic conditions. |
| 10 | Differentiating the health outcomes that result from progressive levels of physical activity (self-reported vs directly measured [pedometers, accelerometers] and cardiorespiratory fitness (estimated from attained speed/grade or kg/min) or directly measured or distance covered during the 6-min walk test. |