Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 R-spondin signaling in the stomach: isthmal Lgr4 rules.

Literature DB >> 35767358

R-spondin signaling in the stomach: isthmal Lgr4 rules.

Ermanno Malagola¹, Yoku Hayakawa², Timothy C Wang¹.

Abstract

R-spondins are critical regulators of gastric epithelial cells, with Lgr5 receptor historically considered as their main signaling transducer. Recent work by Wizenty et al (2022) now revealed distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.

Entities: Chemical

Mesh：

Substances：

Year: 2022 PMID： 35767358 PMCID： PMC9251835 DOI： 10.15252/embj.2022111696

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 14.012

11 in total

1. R-spondin-3 induces secretory, antimicrobial Lgr5⁺ cells in the stomach.

Authors: Michael Sigal; Maria Del Mar Reinés; Stefanie Müllerke; Cornelius Fischer; Marta Kapalczynska; Hilmar Berger; Elvira R M Bakker; Hans-Joachim Mollenkopf; Michael E Rothenberg; Bertram Wiedenmann; Sascha Sauer; Thomas F Meyer
Journal: Nat Cell Biol Date: 2019-06-24 Impact factor: 28.824

2. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Authors: Nick Barker; Meritxell Huch; Pekka Kujala; Marc van de Wetering; Hugo J Snippert; Johan H van Es; Toshiro Sato; Daniel E Stange; Harry Begthel; Maaike van den Born; Esther Danenberg; Stieneke van den Brink; Jeroen Korving; Arie Abo; Peter J Peters; Nick Wright; Richard Poulsom; Hans Clevers
Journal: Cell Stem Cell Date: 2010-01-08 Impact factor: 24.633

3. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

Authors: Wim de Lau; Nick Barker; Teck Y Low; Bon-Kyoung Koo; Vivian S W Li; Hans Teunissen; Pekka Kujala; Andrea Haegebarth; Peter J Peters; Marc van de Wetering; Daniel E Stange; Johan E van Es; Daniele Guardavaccaro; Richard B M Schasfoort; Yasuaki Mohri; Katsuhiko Nishimori; Shabaz Mohammed; Albert J R Heck; Hans Clevers
Journal: Nature Date: 2011-07-04 Impact factor: 49.962

4. Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

Authors: Michael Sigal; Catriona Y Logan; Marta Kapalczynska; Hans-Joachim Mollenkopf; Hilmar Berger; Bertram Wiedenmann; Roeland Nusse; Manuel R Amieva; Thomas F Meyer
Journal: Nature Date: 2017-08-16 Impact factor: 49.962

5. R-spondin signaling in the stomach: isthmal Lgr4 rules.

Authors: Ermanno Malagola; Yoku Hayakawa; Timothy C Wang
Journal: EMBO J Date: 2022-06-29 Impact factor: 14.012

6. Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.

Authors: Jonas Wizenty; Stefanie Müllerke; Marina Kolesnichenko; Julian Heuberger; Manqiang Lin; Anne-Sophie Fischer; Hans-Joachim Mollenkopf; Hilmar Berger; Frank Tacke; Michael Sigal
Journal: EMBO J Date: 2022-06-29 Impact factor: 14.012

7. Identification of stem cells in small intestine and colon by marker gene Lgr5.

Authors: Nick Barker; Johan H van Es; Jeroen Kuipers; Pekka Kujala; Maaike van den Born; Miranda Cozijnsen; Andrea Haegebarth; Jeroen Korving; Harry Begthel; Peter J Peters; Hans Clevers
Journal: Nature Date: 2007-10-14 Impact factor: 49.962

Review 8. Stem cells and origins of cancer in the upper gastrointestinal tract.

Authors: Yoku Hayakawa; Hiroshi Nakagawa; Anil K Rustgi; Jianwen Que; Timothy C Wang
Journal: Cell Stem Cell Date: 2021-06-14 Impact factor: 25.269

9. Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis.

Authors: Wenju Chang; Hongshan Wang; Woosook Kim; Yang Liu; Huan Deng; Haibo Liu; Zhengyu Jiang; Zhengchuan Niu; Weiwei Sheng; Osmel Companioni Nápoles; Yihong Sun; Jianmin Xu; Antonia Sepulveda; Yoku Hayakawa; Adam J Bass; Timothy C Wang
Journal: Cell Stem Cell Date: 2020-03-05 Impact factor: 25.269

10. Non-equivalence of Wnt and R-spondin ligands during Lgr5⁺ intestinal stem-cell self-renewal.

Authors: Kelley S Yan; Claudia Y Janda; Junlei Chang; Grace X Y Zheng; Kathryn A Larkin; Vincent C Luca; Luis A Chia; Amanda T Mah; Arnold Han; Jessica M Terry; Akifumi Ootani; Kelly Roelf; Mark Lee; Jenny Yuan; Xiao Li; Christopher R Bolen; Julie Wilhelmy; Paige S Davies; Hiroo Ueno; Richard J von Furstenberg; Phillip Belgrader; Solongo B Ziraldo; Heather Ordonez; Susan J Henning; Melissa H Wong; Michael P Snyder; Irving L Weissman; Aaron J Hsueh; Tarjei S Mikkelsen; K Christopher Garcia; Calvin J Kuo
Journal: Nature Date: 2017-05-03 Impact factor: 69.504

1 in total

1. R-spondin signaling in the stomach: isthmal Lgr4 rules.

Authors: Ermanno Malagola; Yoku Hayakawa; Timothy C Wang
Journal: EMBO J Date: 2022-06-29 Impact factor: 14.012

1 in total