Literature DB >> 34129814

Stem cells and origins of cancer in the upper gastrointestinal tract.

Yoku Hayakawa1, Hiroshi Nakagawa2, Anil K Rustgi2, Jianwen Que3, Timothy C Wang4.   

Abstract

The esophagus and stomach, joined by a unique transitional zone, contain actively dividing epithelial stem cells required for organ homeostasis. Upon prolonged inflammation, epithelial cells in both organs can undergo a cell fate switch leading to intestinal metaplasia, predisposing to malignancy. Here we discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer. We summarize the interactions between the stromal niche and gastroesophageal stem cells in metaplasia and early expansion of mutated stem-cell-derived clones during carcinogenesis. Finally, we review new approaches under development to better study gastroesophageal stem cells and advance the field.
Copyright © 2021 Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34129814      PMCID： PMC8844710          DOI： 10.1016/j.stem.2021.05.012

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   25.269


  169 in total

1.  The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate.

Authors:  David P Doupé; Allon M Klein; Benjamin D Simons; Philip H Jones
Journal:  Dev Cell       Date:  2010-02-16       Impact factor: 12.270

2.  CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.

Authors:  Yoku Hayakawa; Guangchun Jin; Hongshan Wang; Xiaowei Chen; Christoph B Westphalen; Samuel Asfaha; Bernhard W Renz; Hiroshi Ariyama; Zinaida A Dubeykovskaya; Yoshihiro Takemoto; Yoomi Lee; Ashlesha Muley; Yagnesh Tailor; Duan Chen; Sureshkumar Muthupalani; James G Fox; Arthur Shulkes; Daniel L Worthley; Shigeo Takaishi; Timothy C Wang
Journal:  Gut       Date:  2014-06-20       Impact factor: 23.059

3.  Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells.

Authors:  Robert K Montgomery; Diana L Carlone; Camilla A Richmond; Loredana Farilla; Mariette E G Kranendonk; Daniel E Henderson; Nana Yaa Baffour-Awuah; Dana M Ambruzs; Laura K Fogli; Selma Algra; David T Breault
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-20       Impact factor: 11.205

4.  Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.

Authors:  Cristian Tomasetti; Bert Vogelstein
Journal:  Science       Date:  2015-01-02       Impact factor: 47.728

5.  Gastric Lgr5(+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice.

Authors:  Xiu-Bin Li; Guan Yang; Liang Zhu; Yu-Ling Tang; Chong Zhang; Zhenyu Ju; Xiao Yang; Yan Teng
Journal:  Cell Res       Date:  2016-04-19       Impact factor: 25.617

6.  Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia.

Authors:  Joseph Burclaff; Spencer G Willet; José B Sáenz; Jason C Mills
Journal:  Gastroenterology       Date:  2019-10-05       Impact factor: 22.682

7.  Progression of specialized intestinal metaplasia at the cardia to macroscopically evident Barrett's esophagus: an entity of concern in the ProGERD study.

Authors:  Andreas Leodolter; Marc Nocon; Michael Vieth; Tore Lind; Daniel Jaspersen; Kai Richter; Stefan Willich; Manfred Stolte; Peter Malfertheiner; Joachim Labenz
Journal:  Scand J Gastroenterol       Date:  2012-10-30       Impact factor: 2.423

8.  A single progenitor population switches behavior to maintain and repair esophageal epithelium.

Authors:  David P Doupé; Maria P Alcolea; Amit Roshan; Gen Zhang; Allon M Klein; Benjamin D Simons; Philip H Jones
Journal:  Science       Date:  2012-07-19       Impact factor: 47.728

Review 9.  Gastrin and upper GI cancers.

Authors:  Yoku Hayakawa; Wenju Chang; Guangchun Jin; Timothy C Wang
Journal:  Curr Opin Pharmacol       Date:  2016-08-31       Impact factor: 4.768

10.  Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution.

Authors:  Georg A Busslinger; Bas L A Weusten; Auke Bogte; Harry Begthel; Lodewijk A A Brosens; Hans Clevers
Journal:  Cell Rep       Date:  2021-03-09       Impact factor: 9.423
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  9 in total

1.  R-spondin signaling in the stomach: isthmal Lgr4 rules.

Authors:  Ermanno Malagola; Yoku Hayakawa; Timothy C Wang
Journal:  EMBO J       Date:  2022-06-29       Impact factor: 14.012

2.  In situ gelatinase-responsive and thermosensitive nanocomplex for local therapy of gastric cancer with peritoneal metastasis.

Authors:  Xinyue Wang; Jiahui Gao; Chunhua Li; Chen Xu; Xiang Li; Fanyan Meng; Qin Liu; Qin Wang; Lixia Yu; Baorui Liu; Rutian Li
Journal:  Mater Today Bio       Date:  2022-05-31

3.  DEAD-Box Helicase 27 Triggers Epithelial to Mesenchymal Transition by Regulating Alternative Splicing of Lipoma-Preferred Partner in Gastric Cancer Metastasis.

Authors:  Yirong Jin; Suzhen Yang; Xiaoliang Gao; Di Chen; Tingting Luo; Song Su; Yanting Shi; Gang Yang; Lei Dong; Jie Liang
Journal:  Front Genet       Date:  2022-05-04       Impact factor: 4.772

Review 4.  Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer.

Authors:  Kenly Wuputra; Chia-Chen Ku; Jia-Bin Pan; Chung-Jung Liu; Yi-Chang Liu; Shigeo Saito; Kohsuke Kato; Ying-Chu Lin; Kung-Kai Kuo; Te-Fu Chan; Inn-Wen Chong; Chang-Shen Lin; Deng-Chyang Wu; Kazunari K Yokoyama
Journal:  J Pers Med       Date:  2022-06-03

Review 5.  3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers.

Authors:  Samuel Flashner; Kelley S Yan; Hiroshi Nakagawa
Journal:  Microorganisms       Date:  2021-10-20

6.  Dedifferentiation of esophageal progenitors in metaplasia and cancer.

Authors:  Alizée Vercauteren Drubbel; Benjamin Beck
Journal:  Mol Cell Oncol       Date:  2021-10-21

Review 7.  A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review.

Authors:  Sijia Wang; Liang Li; Christopher Cook; Yufei Zhang; Yumin Xia; Yale Liu
Journal:  Stem Cell Res Ther       Date:  2022-06-21       Impact factor: 8.079

Review 8.  The KEAP1-NRF2 System and Esophageal Cancer.

Authors:  Wataru Hirose; Hiroyuki Oshikiri; Keiko Taguchi; Masayuki Yamamoto
Journal:  Cancers (Basel)       Date:  2022-09-27       Impact factor: 6.575

Review 9.  Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research.

Authors:  Chia-Chen Ku; Kenly Wuputra; Jia-Bin Pan; Chia-Pei Li; Chung-Jung Liu; Yi-Chang Liu; Shigeo Saito; Te-Fu Chan; Chang-Shen Lin; Deng-Chyang Wu; Kazunari K Yokoyama
Journal:  Cells       Date:  2022-01-06       Impact factor: 6.600
  9 in total

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