Literature DB >> 35737162

Modification of a Ready-Made High-Voltage Pulse Generator for Non-Thermal Irreversible Electroporation.

K Zhang1, J Wang2.   

Abstract

We present an inexpensive device for non-thermal irreversible electroporation (IRE) manufactured by upgrading an industrial high-voltage pulse generator. In addition to the generator, the experimental hardware-and-software complex (IRE system) contains a microprocessor and a temperature sensor, which enables automatic control the pulse frequency in accordance with the temperature of the object. The IRE system was tested in in vitro and in vivo experiments: effective and safe non-thermal IRE was demonstrated. The developed system is easily reproducible and can be especially useful for demonstration experiments, pioneering research, as well as for teaching the basics of IRE.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  irreversible electroporation; pulsed electric field; temperature control

Mesh：

Year:  2022        PMID： 35737162     DOI： 10.1007/s10517-022-05533-z

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  10 in total

1.  Design of an irreversible electroporation system for clinical use.

Authors:  Claudio Bertacchini; Pier M Margotti; Enrico Bergamini; Andrea Lodi; Mattia Ronchetti; Ruggero Cadossi
Journal:  Technol Cancer Res Treat       Date:  2007-08

2.  Preclinical analysis of irreversible electroporation on rat liver tissues using a microfabricated electroporator.

Authors:  Youn-Suk Choi; Hong-Bae Kim; Junho Chung; Hyung-Sik Kim; Jeong-Han Yi; Je-Kyun Park
Journal:  Tissue Eng Part C Methods       Date:  2010-04-06       Impact factor: 3.056

3.  A transportable, inexpensive electroporator for in utero electroporation.

Authors:  Torsten Bullmann; Thomas Arendt; Urs Frey; Carina Hanashima
Journal:  Dev Growth Differ       Date:  2015-05-19       Impact factor: 2.053

4.  Portoporator©: A portable low-cost electroporation device for gene transfer to cultured cells in biotechnology, biomedical research and education.

Authors:  Max A Schmitt; Oliver Friedrich; Daniel F Gilbert
Journal:  Biosens Bioelectron       Date:  2019-02-19       Impact factor: 10.618

5.  High-Voltage, Multiphasic, Nanosecond Pulses to Modulate Cellular Responses.

Authors:  Hollie A Ryan; Shinji Hirakawa; Enbo Yang; Chunrong Zhou; Shu Xiao
Journal:  IEEE Trans Biomed Circuits Syst       Date:  2018-04       Impact factor: 3.833

Review 6.  Irreversible electroporation and thermal ablation of tumors in the liver, lung, kidney and bone: What are the differences?

Authors:  L G P H Vroomen; E N Petre; F H Cornelis; S B Solomon; G Srimathveeravalli
Journal:  Diagn Interv Imaging       Date:  2017-08-30       Impact factor: 4.026

7.  Electro-Thermal Therapy Algorithms and Active Internal Electrode Cooling Reduce Thermal Injury in High Frequency Pulsed Electric Field Cancer Therapies.

Authors:  Michael B Sano; Christopher C Fesmire; Ross A Petrella
Journal:  Ann Biomed Eng       Date:  2020-05-15       Impact factor: 3.934

8.  A Digital Controlled Pulse Generator for a Possible Tumor Therapy Combining Irreversible Electroporation With Nanosecond Pulse Stimulation.

Authors:  Xin Rao; Xiaodong Chen; Jun Zhou; Lingling Sun; Jun Liu
Journal:  IEEE Trans Biomed Circuits Syst       Date:  2020-04-17       Impact factor: 3.833

9.  The effect of electroporation pulses on functioning of the heart.

Authors:  Barbara Mali; Tomaz Jarm; Selma Corovic; Marija Snezna Paulin-Kosir; Maja Cemazar; Gregor Sersa; Damijan Miklavcic
Journal:  Med Biol Eng Comput       Date:  2008-04-16       Impact factor: 2.602

Review 10.  Electrochemotherapy as a New Modality in Interventional Oncology: A Review.

Authors:  Ute Probst; Irene Fuhrmann; Lukas Beyer; Philipp Wiggermann
Journal:  Technol Cancer Res Treat       Date:  2018-01-01
  10 in total

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