Semra Ozdemir1,2, Sharon Wan Jie Yeo3, Jia Jia Lee4, Adithya Bhaskar4, Eric Finkelstein4,5,6, Louis Tong3,7,8. 1. Signature Programme in Health Services and Systems Research, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore. semra.ozdemir@duke-nus.edu.sg. 2. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. semra.ozdemir@duke-nus.edu.sg. 3. Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore. 4. Signature Programme in Health Services and Systems Research, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore. 5. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. 6. Duke Global Health Institute, Duke University, Durham, NC, USA. 7. Cornea and External Eye Disease Service, Singapore National Eye Centre, Singapore, Singapore. 8. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Abstract
OBJECTIVES: The side effects of dry eye medications can lead to medication non-adherence and, eventually, to poor outcomes. This study aimed to quantify to what extent the side effects of dry eye disease (DED) medications (burning/stinging sensation and blurring) are important to patients compared to medication benefits or costs. METHODS: Patients diagnosed with DED were recruited at a referral eye center in Singapore (n = 139). This study utilized a Discrete Choice Experiment where patients were presented with 10 choice tasks where they were asked to choose between their current medication (or no medication), and two hypothetical medications that varied based on five attributes: duration of burning/stinging, duration of blurring, time to medication effectiveness, medication frequency, and out-of-pocket cost. The main outcomes were relative attribute importance and predicted uptake. RESULTS: Latent class logistic regressions found two groups with distinct preferences. For both classes, duration of burning/stinging (Class 1 = 23%, Class 2 = 29%) and cost (Class 1 = 24%, Class 2 = 27%) were the most important attributes while duration of blurring (Class 1 = 15%, Class 2 = 9%) was the least important. The predicted uptake of a medication increased 18 percentage-points when burning/stinging duration decreased from 2 h to a few minutes. The predicted uptake for new medications was lowest for those on medication with well-controlled symptoms and highest for those who were not on medication and could not control their symptoms effectively. CONCLUSION: This study showed that duration of burning/stinging was an important factor when choosing medications. Incorporating patient preferences in medication decisions can potentially improve patient acceptance of a treatment regimen.
OBJECTIVES: The side effects of dry eye medications can lead to medication non-adherence and, eventually, to poor outcomes. This study aimed to quantify to what extent the side effects of dry eye disease (DED) medications (burning/stinging sensation and blurring) are important to patients compared to medication benefits or costs. METHODS: Patients diagnosed with DED were recruited at a referral eye center in Singapore (n = 139). This study utilized a Discrete Choice Experiment where patients were presented with 10 choice tasks where they were asked to choose between their current medication (or no medication), and two hypothetical medications that varied based on five attributes: duration of burning/stinging, duration of blurring, time to medication effectiveness, medication frequency, and out-of-pocket cost. The main outcomes were relative attribute importance and predicted uptake. RESULTS: Latent class logistic regressions found two groups with distinct preferences. For both classes, duration of burning/stinging (Class 1 = 23%, Class 2 = 29%) and cost (Class 1 = 24%, Class 2 = 27%) were the most important attributes while duration of blurring (Class 1 = 15%, Class 2 = 9%) was the least important. The predicted uptake of a medication increased 18 percentage-points when burning/stinging duration decreased from 2 h to a few minutes. The predicted uptake for new medications was lowest for those on medication with well-controlled symptoms and highest for those who were not on medication and could not control their symptoms effectively. CONCLUSION: This study showed that duration of burning/stinging was an important factor when choosing medications. Incorporating patient preferences in medication decisions can potentially improve patient acceptance of a treatment regimen.
Authors: Adam J Paulsen; Karen J Cruickshanks; Mary E Fischer; Guan-Hua Huang; Barbara E K Klein; Ronald Klein; Dayna S Dalton Journal: Am J Ophthalmol Date: 2014-01-02 Impact factor: 5.258
Authors: Jennifer P Craig; Kelly K Nichols; Esen K Akpek; Barbara Caffery; Harminder S Dua; Choun-Ki Joo; Zuguo Liu; J Daniel Nelson; Jason J Nichols; Kazuo Tsubota; Fiona Stapleton Journal: Ocul Surf Date: 2017-07-20 Impact factor: 5.033
Authors: Steven Holfinger; Alexander G Miller; Llewelyn J Rao; Douglas Y Rowland; Joan H Hornik; David G Miller Journal: JAMA Ophthalmol Date: 2016-01 Impact factor: 7.389