Literature DB >> 35670230

Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package.

Jean-Francois Marier1, Nathan Teuscher1, Mohamad-Samer Mouksassi1,2,3.   

Abstract

The current tutorial describes why forest plots are needed for an effective communication of covariates effects, how they are constructed, and how they should be presented. Simulation-based methodologies allowing the user to evaluate the marginal impact of changing one covariate at a time or by considering the joint effects of correlated covariates are introduced along with graphical tools for an optimal assessment of the covariate effects. The R package coveffectsplot and an associated R Shiny application are provided to facilitate the design and construction of forest plots for the visualization of covariate effects. All codes and materials are available on a public Github repository.
© 2022 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

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Year:  2022        PMID: 35670230      PMCID: PMC9574733          DOI: 10.1002/psp4.12829

Source DB:  PubMed          Journal:  CPT Pharmacometrics Syst Pharmacol        ISSN: 2163-8306


  6 in total

1.  Essential pharmacokinetic information for drug dosage decisions: a concise visual presentation in the drug label.

Authors:  D Menon-Andersen; B Yu; R Madabushi; V Bhattaram; W Hao; R S Uppoor; M Mehta; L Lesko; R Temple; N Stockbridge; T Laughren; J V Gobburu
Journal:  Clin Pharmacol Ther       Date:  2011-07-27       Impact factor: 6.875

2.  The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials.

Authors:  J A Freiman; T C Chalmers; H Smith; R R Kuebler
Journal:  N Engl J Med       Date:  1978-09-28       Impact factor: 91.245

3.  Full covariate modelling approach in population pharmacokinetics: understanding the underlying hypothesis tests and implications of multiplicity.

Authors:  Xu Steven Xu; Min Yuan; Hao Zhu; Yaning Yang; Hui Wang; Honghui Zhou; Jinfeng Xu; Liping Zhang; Jose Pinheiro
Journal:  Br J Clin Pharmacol       Date:  2018-05-03       Impact factor: 4.335

4.  Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package.

Authors:  Jean-Francois Marier; Nathan Teuscher; Mohamad-Samer Mouksassi
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2022-06-27

5.  Effective Visual Communication for the Quantitative Scientist.

Authors:  Marc Vandemeulebroecke; Mark Baillie; Alison Margolskee; Baldur Magnusson
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2019-08-30

6.  Communicating to Influence Drug Development and Regulatory Decisions: A Tutorial.

Authors:  S Mehrotra; J Gobburu
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2016-04-14
  6 in total
  1 in total

1.  Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package.

Authors:  Jean-Francois Marier; Nathan Teuscher; Mohamad-Samer Mouksassi
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2022-06-27
  1 in total

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