Literature DB >> 3562226

DNA sequence preferences for an intercalating porphyrin compound revealed by footprinting.

K Ford, K R Fox, S Neidle, M J Waring.   

Abstract

The DNA sequence preferences of the compound meso-tetra-(4-N-methyl(pyridyl) porphyrin and its nickel complex have been investigated by means of footprinting experiments on several DNA fragments, using DNAase I and micrococcal nuclease as footprinting agents. A complex pattern of both AT and GC-protected sites was found. Ligand-induced long-range conformational changes were inferred in several instances to be related to the observed large-scale blockages of enzymatic cutting.

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Year:  1987        PMID： 3562226      PMCID： PMC340629          DOI： 10.1093/nar/15.5.2221

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  18 in total

1.  Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences.

Authors:  C M Low; H R Drew; M J Waring
Journal:  Nucleic Acids Res       Date:  1984-06-25       Impact factor: 16.971

2.  High sequence specificity of micrococcal nuclease.

Authors:  C Dingwall; G P Lomonossoff; R A Laskey
Journal:  Nucleic Acids Res       Date:  1981-06-25       Impact factor: 16.971

3.  DNA structural variations in the E. coli tyrT promoter.

Authors:  H R Drew; A A Travers
Journal:  Cell       Date:  1984-06       Impact factor: 41.582

4.  Molecular models for the interaction of the anti-tumour drug nogalamycin with DNA.

Authors:  D A Collier; S Neidle; J R Brown
Journal:  Biochem Pharmacol       Date:  1984-09-15       Impact factor: 5.858

5.  A comparative study of the interaction of 5,10,15,20-tetrakis (N-methylpyridinium-4-yl)porphyrin and its zinc complex with DNA using fluorescence spectroscopy and topoisomerisation.

Authors:  J M Kelly; M J Murphy; D J McConnell; C OhUigin
Journal:  Nucleic Acids Res       Date:  1985-01-11       Impact factor: 16.971

6.  Interactions of porphyrins with nucleic acids.

Authors:  R F Pasternack; E J Gibbs; J J Villafranca
Journal:  Biochemistry       Date:  1983-11-08       Impact factor: 3.162

7.  Intercalative and nonintercalative binding of large cationic porphyrin ligands to polynucleotides.

Authors:  M J Carvlin; E Mark; R Fiel; J C Howard
Journal:  Nucleic Acids Res       Date:  1983-09-10       Impact factor: 16.971

8.  31P NMR and viscometric studies of the interaction of meso-tetra(4-N-methylpyridyl) porphine and its Ni(II) and Zn(II) derivatives with DNA.

Authors:  D L Banville; L G Marzilli; W D Wilson
Journal:  Biochem Biophys Res Commun       Date:  1983-05-31       Impact factor: 3.575

9.  Interactions of water soluble porphyrins with Z-poly(dG-dC).

Authors:  R F Pasternack; D Sidney; P A Hunt; E A Snowden; E J Gibbs
Journal:  Nucleic Acids Res       Date:  1986-05-12       Impact factor: 16.971

10.  DNA structural variations produced by actinomycin and distamycin as revealed by DNAase I footprinting.

Authors:  K R Fox; M J Waring
Journal:  Nucleic Acids Res       Date:  1984-12-21       Impact factor: 16.971
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  6 in total

1.  A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling.

Authors:  M Bennett; A Krah; F Wien; E Garman; R McKenna; M Sanderson; S Neidle
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

2.  A molecular model for proflavine-DNA intercalation.

Authors:  S Neidle; L H Pearl; P Herzyk; H M Berman
Journal:  Nucleic Acids Res       Date:  1988-09-26       Impact factor: 16.971

3.  Molecular modelling of the interactions of tetra-(4-N-methylpyridyl) porphin with TA and CG sites on DNA.

Authors:  K G Ford; L H Pearl; S Neidle
Journal:  Nucleic Acids Res       Date:  1987-08-25       Impact factor: 16.971

4.  Sequence-dependent reactivity of linear DNA to chemical cleavage by Cu(II):thiol combinations including cysteine or glutathione.

Authors:  D C John; K T Douglas
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857

5.  Modelling of the binding specificity in the interactions of cationic porphyrins with DNA.

Authors:  X W Hui; N Gresh; B Pullman
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

6.  Interactions of water-soluble metalloporphyrins with nucleic acids studied by resonance Raman spectroscopy.

Authors:  J H Schneider; J Odo; K Nakamoto
Journal:  Nucleic Acids Res       Date:  1988-11-11       Impact factor: 16.971
  6 in total

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