Literature DB >> 3174439

A molecular model for proflavine-DNA intercalation.

S Neidle1, L H Pearl, P Herzyk, H M Berman.   

Abstract

A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereochemically acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.

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Year:  1988        PMID： 3174439      PMCID： PMC338648          DOI： 10.1093/nar/16.18.8999

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  28 in total

1.  Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

Authors:  H M Berman; S Neidle; R K Stodola
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

2.  Structural model for an oligonucleotide containing a bulged guanosine by NMR and energy minimization.

Authors:  S A Woodson; D M Crothers
Journal:  Biochemistry       Date:  1988-05-03       Impact factor: 3.162

3.  Stereochemistry of actinomycin binding to DNA. II. Detailed molecular model of actinomycin-DNA complex and its implications.

Authors:  H M Sobell; S C Jain
Journal:  J Mol Biol       Date:  1972-07-14       Impact factor: 5.469

Review 4.  Intercalating drugs: DNA binding and molecular pharmacology.

Authors:  W D Wilson; R L Jones
Journal:  Adv Pharmacol Chemother       Date:  1981

5.  Structure of a B-DNA dodecamer. II. Influence of base sequence on helix structure.

Authors:  R E Dickerson; H R Drew
Journal:  J Mol Biol       Date:  1981-07-15       Impact factor: 5.469

Review 6.  The interaction of intercalating drugs with nucleic acids.

Authors:  H M Berman; P R Young
Journal:  Annu Rev Biophys Bioeng       Date:  1981

7.  Visualization of drug-nucleic acid interactions at atomic resolution. III. Unifying structural concepts in understanding drug-DNA interactions and their broader implications in understanding protein-DNA interactions.

Authors:  H M Sobell; C C Tsai; S C Jain; S G Gilbert
Journal:  J Mol Biol       Date:  1977-08-15       Impact factor: 5.469

8.  Interaction of molecules with nucleic acids. II. Two pairs of families of intercalation sites, unwinding angles, and the neighbor-exclusion principle.

Authors:  K J Miller; J F Pycior
Journal:  Biopolymers       Date:  1979-11       Impact factor: 2.505

9.  Stereochemical model for proflavin intercalation in A-DNA.

Authors:  C J Alden; S Arnott
Journal:  Nucleic Acids Res       Date:  1977-11       Impact factor: 16.971

10.  The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.

Authors:  H S Shieh; H M Berman; M Dabrow; S Neidle
Journal:  Nucleic Acids Res       Date:  1980-01-11       Impact factor: 16.971
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  6 in total

1.  Nucleotide excision repair efficiencies of bulky carcinogen-DNA adducts are governed by a balance between stabilizing and destabilizing interactions.

Authors:  Yuqin Cai; Nicholas E Geacintov; Suse Broyde
Journal:  Biochemistry       Date:  2012-02-09       Impact factor: 3.162

2.  Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.

Authors:  Amit Kumar; Raman Parkesh; Lukasz J Sznajder; Jessica L Childs-Disney; Krzysztof Sobczak; Matthew D Disney
Journal:  ACS Chem Biol       Date:  2012-01-17       Impact factor: 5.100

3.  Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.

Authors:  Yijin Tang; Zhi Liu; Shuang Ding; Chin H Lin; Yuqin Cai; Fabian A Rodriguez; Jane M Sayer; Donald M Jerina; Shantu Amin; Suse Broyde; Nicholas E Geacintov
Journal:  Biochemistry       Date:  2012-11-15       Impact factor: 3.162

Review 4.  Medicinal chemistry of acridine and its analogues.

Authors:  Parteek Prasher; Mousmee Sharma
Journal:  Medchemcomm       Date:  2018-08-14       Impact factor: 3.597

5.  Anticancer activity expressed by a library of 2,9-diazaperopyrenium dications.

Authors:  Karel J Hartlieb; Leah S Witus; Daniel P Ferris; Ashish N Basuray; Mohammed M Algaradah; Amy A Sarjeant; Charlotte L Stern; Majed S Nassar; Youssry Y Botros; J Fraser Stoddart
Journal:  ACS Nano       Date:  2015-01-23       Impact factor: 15.881

6.  Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies.

Authors:  Hong Mu; Konstantin Kropachev; Lihua Wang; Lu Zhang; Alexander Kolbanovskiy; Marina Kolbanovskiy; Nicholas E Geacintov; Suse Broyde
Journal:  Nucleic Acids Res       Date:  2012-08-16       Impact factor: 16.971
  6 in total

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