Literature DB >> 6477647

Molecular models for the interaction of the anti-tumour drug nogalamycin with DNA.

D A Collier, S Neidle, J R Brown.   

Abstract

Computer graphics and non-bonded energy calculations have been used to model the intercalative binding of the anti-tumour antibiotic nogalamycin, to double-stranded DNA. The drug is predicted to bind preferentially to A-T rich sites. Specific hydrogen bonds to the exocyclic amino group of adenine bases on the 3' side of an intercalative site have been found by the modelling procedure.

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Year:  1984        PMID： 6477647     DOI： 10.1016/0006-2952(84)90210-7

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  8 in total

1.  Footprinting reveals that nogalamycin and actinomycin shuffle between DNA binding sites.

Authors:  K R Fox; M J Waring
Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

Review 2.  DNA structure and perturbation by drug binding.

Authors:  S Neidle; L H Pearl; J V Skelly
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857

3.  Antibiotics which can alter the rotational orientation of nucleosome core DNA.

Authors:  J Portugal; M J Waring
Journal:  Nucleic Acids Res       Date:  1986-11-25       Impact factor: 16.971

4.  Structure of nogalamycin bound to a DNA hexamer.

Authors:  L D Williams; M Egli; G Qi; P Bash; G A van der Marel; J H van Boom; A Rich; C A Frederick
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

5.  DNA sequence preferences for an intercalating porphyrin compound revealed by footprinting.

Authors:  K Ford; K R Fox; S Neidle; M J Waring
Journal:  Nucleic Acids Res       Date:  1987-03-11       Impact factor: 16.971

Review 6.  Mechanism of DNA-drug interactions.

Authors:  P Prabhakar; A M Kayastha
Journal:  Appl Biochem Biotechnol       Date:  1994-04       Impact factor: 2.926

Review 7.  A chemical perspective on the anthracycline antitumor antibiotics.

Authors:  B R Abdella; J Fisher
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031

8.  Crystal structure of trioxacarcin A covalently bound to DNA.

Authors:  Roland Pfoh; Hartmut Laatsch; George M Sheldrick
Journal:  Nucleic Acids Res       Date:  2008-05-03       Impact factor: 16.971
  8 in total

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