| Literature DB >> 35597865 |
Amir Anbiyaiee1, Mohammad Ramazii2, Siamak Soltani Bajestani3, Seyed Mohammadmahdi Meybodi4, Mona Keivan5, Seyed Esmaeil Khoshnam6, Maryam Farzaneh7.
Abstract
Cancer as a progressive and complex disease is caused by early chromosomal changes and stimulated cellular transformation. Previous studies reported that long non-coding RNAs (lncRNAs) play pivotal roles in the initiation, maintenance, and progression of cancer cells. LncRNA activated by TGF-β (ATB) has been shown to be dysregulated in different types of cancer. Aberrant expression of lncRNA-ATB plays an important role in the progression of diverse malignancies. High expression of LncRNA-ATB is associated with cancer cell growth, proliferation, metastasis, and EMT. LncRNA-ATB by targeting various signaling pathways and microRNAs (miRNAs) can trigger cancer pathogenesis. Therefore, lncRNA-ATB can be a novel target for cancer prediction and diagnosis. In this review, we will focus on the function of lncRNA-ATB in various types of human cancers.Entities:
Keywords: Cancer; LncRNA-ATB; Long non-coding RNAs; Signaling pathways; miRNAs
Year: 2022 PMID: 35597865 DOI: 10.1007/s12094-022-02848-1
Source DB: PubMed Journal: Clin Transl Oncol ISSN: 1699-048X Impact factor: 3.405