Literature DB >> 31392074

Emerging roles of lncRNA in cancer and therapeutic opportunities.

Ming-Chun Jiang1, Jiao-Jiao Ni1,2, Wen-Yu Cui1, Bo-Ya Wang3,2, Wei Zhuo1,2.   

Abstract

Cancer is difficult to cure due to frequent metastasis, and developing effective therapeutic approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have diverse roles in regulating gene expression at both the transcriptional and translational levels and have been reported to be involved in tumorigenesis and tumor metastasis. In this article, we review the emerging roles of lncRNAs in cancer, especially in cancer immunity, cancer metabolism and cancer metastasis. We also discuss the use of novel technologies, such as antisense oligonucleotides, CRISPR-Cas9 and nanomedicines, to target lncRNAs and thus control cancers.

Entities:  

Keywords:  ASO; CRISPR-Cas9; LncRNA; nanomedicine; tumor metastasis; tumorigenesis; virus

Year:  2019        PMID： 31392074      PMCID： PMC6682721     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  111 in total

1.  Features of systemic lupus erythematosus in Dnase1-deficient mice.

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Journal:  Nat Genet       Date:  2000-06       Impact factor: 38.330

2.  Antisense transcription in the mammalian transcriptome.

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Journal:  Science       Date:  2005-09-02       Impact factor: 47.728

3.  Experimental validation of the importance of seed complement frequency to siRNA specificity.

Authors:  Emily M Anderson; Amanda Birmingham; Scott Baskerville; Angela Reynolds; Elena Maksimova; Devin Leake; Yuriy Fedorov; Jon Karpilow; Anastasia Khvorova
Journal:  RNA       Date:  2008-03-26       Impact factor: 4.942

4.  A system for stable expression of short interfering RNAs in mammalian cells.

Authors:  Thijn R Brummelkamp; René Bernards; Reuven Agami
Journal:  Science       Date:  2002-03-21       Impact factor: 47.728

Review 5.  The changing face of prostate cancer.

Authors:  Matthew R Cooperberg; Judd W Moul; Peter R Carroll
Journal:  J Clin Oncol       Date:  2005-11-10       Impact factor: 44.544

6.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.

Authors:  S M Elbashir; J Harborth; W Lendeckel; A Yalcin; K Weber; T Tuschl
Journal:  Nature       Date:  2001-05-24       Impact factor: 49.962

7.  Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions.

Authors:  Anna Astriab-Fisher; Dimitri Sergueev; Michael Fisher; Barbara Ramsay Shaw; R L Juliano
Journal:  Pharm Res       Date:  2002-06       Impact factor: 4.200

8.  Activation of p53 by MEG3 non-coding RNA.

Authors:  Yunli Zhou; Ying Zhong; Yingying Wang; Xun Zhang; Dalia L Batista; Roger Gejman; Peter J Ansell; Jing Zhao; Catherine Weng; Anne Klibanski
Journal:  J Biol Chem       Date:  2007-06-13       Impact factor: 5.157

9.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods.

Authors:  Xiaohua Huang; Ivan H El-Sayed; Wei Qian; Mostafa A El-Sayed
Journal:  J Am Chem Soc       Date:  2006-02-15       Impact factor: 15.419

10.  Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells.

Authors:  Tao Yang; Min-Koo Choi; Fu-De Cui; Seung-Jin Lee; Suk-Jae Chung; Chang-Koo Shim; Dae-Duk Kim
Journal:  Pharm Res       Date:  2007-09-09       Impact factor: 4.580
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  157 in total

1.  Long noncoding RNA LINC00520 accelerates progression of papillary thyroid carcinoma by serving as a competing endogenous RNA of microRNA-577 to increase Sphk2 expression.

Authors:  Yu Sun; Tiefeng Shi; Yanfei Ma; Huadong Qin; Kang Li
Journal:  Cell Cycle       Date:  2020-02-20       Impact factor: 4.534

2.  Single-Cell RNAseq Analysis of lncRNAs.

Authors:  Stefano Cagnin; Enrico Alessio; Raphael Severino Bonadio; Gabriele Sales
Journal:  Methods Mol Biol       Date:  2021

3.  Long non-coding RNA TIRY promotes tumor metastasis by enhancing epithelial-to-mesenchymal transition in oral cancer.

Authors:  Nuo Jin; Nianqiang Jin; Wenhuan Bu; Xing Li; Lili Liu; Zilin Wang; Jin Tong; Dechao Li
Journal:  Exp Biol Med (Maywood)       Date:  2020-02-26

Review 4.  Long noncoding RNA loss in immune suppression in cancer.

Authors:  Qingsong Hu; Sergey D Egranov; Chunru Lin; Liuqing Yang
Journal:  Pharmacol Ther       Date:  2020-05-29       Impact factor: 12.310

5.  The role of long non-coding RNAs in mediating chemoresistance by modulating autophagy in cancer.

Authors:  Ke-Tao Jin; Ze-Bei Lu; Jie-Qing Lv; Jun-Gang Zhang
Journal:  RNA Biol       Date:  2020-03-15       Impact factor: 4.652

6.  Aptamer-guided targeting of the intracellular long-noncoding RNA HOTAIR.

Authors:  Yuan-Liang Wang; Ling-Chu Chang; Kuen-Bao Chen; Shao-Chun Wang
Journal:  Am J Cancer Res       Date:  2021-03-01       Impact factor: 6.166

7.  Long noncoding RNA LINC00657 enhances the malignancy of pancreatic ductal adenocarcinoma by acting as a competing endogenous RNA on microRNA-433 to increase PAK4 expression.

Authors:  Shasha Bi; Yan Wang; Hu Feng; Qingchang Li
Journal:  Cell Cycle       Date:  2020-03-01       Impact factor: 4.534

8.  Long noncoding RNA LINC00520 accelerates the progression of colorectal cancer by serving as a competing endogenous RNA of microRNA-577 to increase HSP27 expression.

Authors:  Xi-Han Jin; Yong-Gang Hong; Peng Li; Li-Qiang Hao; Ming Chen
Journal:  Hum Cell       Date:  2020-03-07       Impact factor: 4.174

9.  Induction of epithelial-mesenchymal transition (EMT) by hypoxia-induced lncRNA RP11-367G18.1 through regulating the histone 4 lysine 16 acetylation (H4K16Ac) mark.

Authors:  Pei-Hua Peng; Joseph Chieh-Yu Lai; Jeng-Shou Chang; Kai-Wen Hsu; Kou-Juey Wu
Journal:  Am J Cancer Res       Date:  2021-06-15       Impact factor: 6.166

10.  LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing.

Authors:  Yang-Hsiang Lin; Meng-Han Wu; Yi-Chung Liu; Ping-Chiang Lyu; Chau-Ting Yeh; Kwang-Huei Lin
Journal:  Oncogene       Date:  2021-06-17       Impact factor: 9.867
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