Mehmet Gul1, Serkan Dundar2, Alihan Bozoglan2, Erhan Cahit Ozcan3, Samet Tekin4, Tuba Talo Yildirim2, Necmettin Karasu5, Muhammet Bahattin Bingul6. 1. Sanliurfa Harran University, Department of Periodontology, Faculty of Dentistry, Sanliurfa, Turkiye. 2. Firat University, Department of Periodontology, Faculty of Dentistry, Elazig, Turkiye. 3. Firat University, Department of Esthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, Elazig, Turkiye. 4. Firat University, Department of Protetic Dentistry, Faculty of Dentistry, Elazig, Turkiye. 5. Afyonkarahisar Health Sciences University, Department of Esthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, Afyonkarahisar, Turkiye. 6. Sanliurfa Harran University, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sanliurfa, Turkiye.
Abstract
Objective: Investigations of the effects of proton pump inhibitors (PPIs) on bone healing have revealed that they affect bone regeneration negatively. The exact mechanism by which this adverse effect on bone tissue is not known. The aim of this study is to biomechanic and biochemical investigation of the effects of the PPIs on guided periimplant bone regeneration. Material & methods: Spraque dawley rats were divided controls (n = 8): there is no treatment during 8 week experimental period, PPI- Dosage 1 (n = 8) and Dosage 2 (n = 8): 5 mg/kg and 10 mg/kg omeprazol applied 3 times in a week with oral gavage during 8 weeks respectfully. Bone defects created half of the implant length circumferencial after implant insertion and defects filled with bone grafts. After experimental period the rats sacrified and implants with surrounding bone tissues were removed to reverse torque analysis (Newton), blood samples collected to biochemical analysis (glucose, AST, ALT, ALP, urea, creatinin, calcium, P). Results: Biomechanic reverse torque values did not revealed any statistical differences between the groups (P > 0,05). Conclusion: According the biomechanical and biochemical parameters PPIs does not effect the periimplant guided bone regeneration.
Objective: Investigations of the effects of proton pump inhibitors (PPIs) on bone healing have revealed that they affect bone regeneration negatively. The exact mechanism by which this adverse effect on bone tissue is not known. The aim of this study is to biomechanic and biochemical investigation of the effects of the PPIs on guided periimplant bone regeneration. Material & methods: Spraque dawley rats were divided controls (n = 8): there is no treatment during 8 week experimental period, PPI- Dosage 1 (n = 8) and Dosage 2 (n = 8): 5 mg/kg and 10 mg/kg omeprazol applied 3 times in a week with oral gavage during 8 weeks respectfully. Bone defects created half of the implant length circumferencial after implant insertion and defects filled with bone grafts. After experimental period the rats sacrified and implants with surrounding bone tissues were removed to reverse torque analysis (Newton), blood samples collected to biochemical analysis (glucose, AST, ALT, ALP, urea, creatinin, calcium, P). Results: Biomechanic reverse torque values did not revealed any statistical differences between the groups (P > 0,05). Conclusion: According the biomechanical and biochemical parameters PPIs does not effect the periimplant guided bone regeneration.
Authors: T Histing; D Stenger; C Scheuer; W Metzger; P Garcia; J H Holstein; M Klein; T Pohlemann; M D Menger Journal: Calcif Tissue Int Date: 2012-04-24 Impact factor: 4.333