BACKGROUND: Proton pump inhibitors, over-the-counter drugs taken by millions of patients, diminish bone accrual. Accordingly, we hypothesized that these drugs could impair bone healing and implant osseointegration. This study investigated the effect of post-operative systemic administration of omeprazole on bone healing and implant osseointegration in rat tibiae. METHODS: In 24 Sprague-Dawley rats, a titanium implant was placed in the left tibia, and a bone defect was created in the right tibia. During the 2 weeks following surgery, 12 rats were treated with omeprazole (5 mg/kg, daily) and the other 12 with saline. Then, after euthanasia, the volume (mm(3) ) of the cortical defect and the percentages of newly formed bone in the defect, were assessed using microcomputed tomography; peri-implant bone volume/tissue volume and bone-implant contact percentage were assessed by histomorphometry. RESULTS: Omeprazole-treated rats presented larger cortical defects (2.75 ± 0.59 mm(3) , p = 0.003 versus 2.11 ± 0.36 mm(3) ; p = 0.002) and a lower percentage of newly formed bone in the defects (28.62 ± 13.12; 45.89 ± 9.73; p = 0.003) than controls. Omeprazole-treated rats presented lower peri-implant bone volume/tissue volume (14.3 ± 7.3% versus 30.8 ± 11.0%; p < 0.001) and bone-implant contact (23.3 ± 10.8% versus 41.8 ± 13.3%; p < 0.001) than controls. CONCLUSION: Systemically administered omeprazole impairs bone healing and implant osseointegration.
BACKGROUND: Proton pump inhibitors, over-the-counter drugs taken by millions of patients, diminish bone accrual. Accordingly, we hypothesized that these drugs could impair bone healing and implant osseointegration. This study investigated the effect of post-operative systemic administration of omeprazole on bone healing and implant osseointegration in rat tibiae. METHODS: In 24 Sprague-Dawley rats, a titanium implant was placed in the left tibia, and a bone defect was created in the right tibia. During the 2 weeks following surgery, 12 rats were treated with omeprazole (5 mg/kg, daily) and the other 12 with saline. Then, after euthanasia, the volume (mm(3) ) of the cortical defect and the percentages of newly formed bone in the defect, were assessed using microcomputed tomography; peri-implant bone volume/tissue volume and bone-implant contact percentage were assessed by histomorphometry. RESULTS:Omeprazole-treated rats presented larger cortical defects (2.75 ± 0.59 mm(3) , p = 0.003 versus 2.11 ± 0.36 mm(3) ; p = 0.002) and a lower percentage of newly formed bone in the defects (28.62 ± 13.12; 45.89 ± 9.73; p = 0.003) than controls. Omeprazole-treated rats presented lower peri-implant bone volume/tissue volume (14.3 ± 7.3% versus 30.8 ± 11.0%; p < 0.001) and bone-implant contact (23.3 ± 10.8% versus 41.8 ± 13.3%; p < 0.001) than controls. CONCLUSION: Systemically administered omeprazole impairs bone healing and implant osseointegration.
Authors: Iskandar Tamimi; Pablo Carnero; David Bautista; David Gonzalez; Pablo Rodrigo; María Jose Bravo; Abel Gómez; Faleh Tamimi; David Garcia de Quevedo Journal: Geriatr Orthop Surg Rehabil Date: 2022-04-11
Authors: John J Mangan; Srikanth N Divi; James C McKenzie; Justin D Stull; William Conaway; David S Casper; Dhruv K C Goyal; Kristen J Nicholson; Matthew S Galetta; Scott C Wagner; I David Kaye; Mark F Kurd; Barrett I Woods; Kristen E Radcliff; Jeffery A Rihn; D Greg Anderson; Alan S Hilibrand; Alexander R Vaccaro; Gregory D Schroeder; Christopher K Kepler Journal: Global Spine J Date: 2019-06-10
Authors: Faez Saleh Al-Hamed; Ola M Maria; Jeff Phan; Ahmed Al Subaie; Qiman Gao; Alaa Mansour; Lina Abu Nada; Imane Boukhatem; Osama A Elkashty; Simon D Tran; Marie Lordkipanidzé; Zahi Badran; Faleh Tamimi Journal: Biomolecules Date: 2020-09-14