Literature DB >> 35587846

Genetics of atrial fibrillation-an update of recent findings.

Aarthi Manoharan1, Ravikumar Sambandam2, Vishnu Bhat Ballambattu1.   

Abstract

Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. The consensus from GWAS implies that AF is both polygenic and pleiotropic in nature. With the advent of whole-genome sequencing and whole-exome sequencing, rare variants associated with AF pathogenesis have been identified. The recent studies have contributed towards better understanding of AF pathogenesis.
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.

Entities:  

Keywords:  Atrial fibrillation; Genome-wide association studies; Whole-exome sequencing; Whole-genome sequencing

Mesh：

Year:  2022        PMID： 35587846     DOI： 10.1007/s11033-022-07420-2

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.742


  67 in total

1.  Association between familial atrial fibrillation and risk of new-onset atrial fibrillation.

Authors:  Steven A Lubitz; Xiaoyan Yin; João D Fontes; Jared W Magnani; Michiel Rienstra; Manju Pai; Mark L Villalon; Ramachandran S Vasan; Michael J Pencina; Daniel Levy; Martin G Larson; Patrick T Ellinor; Emelia J Benjamin
Journal:  JAMA       Date:  2010-11-13       Impact factor: 56.272

2.  Incidence of Atrial Fibrillation and Relationship With Cardiovascular Events, Heart Failure, and Mortality: A Community-Based Study From the Netherlands.

Authors:  Rob A Vermond; Bastiaan Geelhoed; Niek Verweij; Robert G Tieleman; Pim Van der Harst; Hans L Hillege; Wiek H Van Gilst; Isabelle C Van Gelder; Michiel Rienstra
Journal:  J Am Coll Cardiol       Date:  2015-09-01       Impact factor: 24.094

Review 3.  Emerging directions in the genetics of atrial fibrillation.

Authors:  Nathan R Tucker; Patrick T Ellinor
Journal:  Circ Res       Date:  2014-04-25       Impact factor: 17.367

4.  Large-scale whole-genome sequencing of the Icelandic population.

Authors:  Daniel F Gudbjartsson; Hannes Helgason; Sigurjon A Gudjonsson; Florian Zink; Asmundur Oddson; Arnaldur Gylfason; Soren Besenbacher; Gisli Magnusson; Bjarni V Halldorsson; Eirikur Hjartarson; Gunnar Th Sigurdsson; Simon N Stacey; Michael L Frigge; Hilma Holm; Jona Saemundsdottir; Hafdis Th Helgadottir; Hrefna Johannsdottir; Gunnlaugur Sigfusson; Gudmundur Thorgeirsson; Jon Th Sverrisson; Solveig Gretarsdottir; G Bragi Walters; Thorunn Rafnar; Bjarni Thjodleifsson; Einar S Bjornsson; Sigurdur Olafsson; Hildur Thorarinsdottir; Thora Steingrimsdottir; Thora S Gudmundsdottir; Asgeir Theodors; Jon G Jonasson; Asgeir Sigurdsson; Gyda Bjornsdottir; Jon J Jonsson; Olafur Thorarensen; Petur Ludvigsson; Hakon Gudbjartsson; Gudmundur I Eyjolfsson; Olof Sigurdardottir; Isleifur Olafsson; David O Arnar; Olafur Th Magnusson; Augustine Kong; Gisli Masson; Unnur Thorsteinsdottir; Agnar Helgason; Patrick Sulem; Kari Stefansson
Journal:  Nat Genet       Date:  2015-03-25       Impact factor: 38.330

5.  Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC).

Authors:  A John Camm; Paulus Kirchhof; Gregory Y H Lip; Ulrich Schotten; Irene Savelieva; Sabine Ernst; Isabelle C Van Gelder; Nawwar Al-Attar; Gerhard Hindricks; Bernard Prendergast; Hein Heidbuchel; Ottavio Alfieri; Annalisa Angelini; Dan Atar; Paolo Colonna; Raffaele De Caterina; Johan De Sutter; Andreas Goette; Bulent Gorenek; Magnus Heldal; Stefan H Hohloser; Philippe Kolh; Jean-Yves Le Heuzey; Piotr Ponikowski; Frans H Rutten
Journal:  Eur Heart J       Date:  2010-08-29       Impact factor: 29.983

6.  Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring.

Authors:  Caroline S Fox; Helen Parise; Ralph B D'Agostino; Donald M Lloyd-Jones; Ramachandran S Vasan; Thomas J Wang; Daniel Levy; Philip A Wolf; Emelia J Benjamin
Journal:  JAMA       Date:  2004-06-16       Impact factor: 56.272

7.  Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study.

Authors:  Sumeet S Chugh; Rasmus Havmoeller; Kumar Narayanan; David Singh; Michiel Rienstra; Emelia J Benjamin; Richard F Gillum; Young-Hoon Kim; John H McAnulty; Zhi-Jie Zheng; Mohammad H Forouzanfar; Mohsen Naghavi; George A Mensah; Majid Ezzati; Christopher J L Murray
Journal:  Circulation       Date:  2013-12-17       Impact factor: 29.690

8.  Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation.

Authors:  Morten S Olesen; Laura Andreasen; Javad Jabbari; Lena Refsgaard; Stig Haunsø; Søren-Peter Olesen; Jonas B Nielsen; Nicole Schmitt; Jesper H Svendsen
Journal:  Heart Rhythm       Date:  2013-10-18       Impact factor: 6.343

9.  Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Authors:  Ingrid E Christophersen; Michiel Rienstra; Carolina Roselli; Xiaoyan Yin; Bastiaan Geelhoed; John Barnard; Honghuang Lin; Dan E Arking; Albert V Smith; Christine M Albert; Mark Chaffin; Nathan R Tucker; Molong Li; Derek Klarin; Nathan A Bihlmeyer; Siew-Kee Low; Peter E Weeke; Martina Müller-Nurasyid; J Gustav Smith; Jennifer A Brody; Maartje N Niemeijer; Marcus Dörr; Stella Trompet; Jennifer Huffman; Stefan Gustafsson; Claudia Schurmann; Marcus E Kleber; Leo-Pekka Lyytikäinen; Ilkka Seppälä; Rainer Malik; Andrea R V R Horimoto; Marco Perez; Juha Sinisalo; Stefanie Aeschbacher; Sébastien Thériault; Jie Yao; Farid Radmanesh; Stefan Weiss; Alexander Teumer; Seung Hoan Choi; Lu-Chen Weng; Sebastian Clauss; Rajat Deo; Daniel J Rader; Svati H Shah; Albert Sun; Jemma C Hopewell; Stephanie Debette; Ganesh Chauhan; Qiong Yang; Bradford B Worrall; Guillaume Paré; Yoichiro Kamatani; Yanick P Hagemeijer; Niek Verweij; Joylene E Siland; Michiaki Kubo; Jonathan D Smith; David R Van Wagoner; Joshua C Bis; Siegfried Perz; Bruce M Psaty; Paul M Ridker; Jared W Magnani; Tamara B Harris; Lenore J Launer; M Benjamin Shoemaker; Sandosh Padmanabhan; Jeffrey Haessler; Traci M Bartz; Melanie Waldenberger; Peter Lichtner; Marina Arendt; Jose E Krieger; Mika Kähönen; Lorenz Risch; Alfredo J Mansur; Annette Peters; Blair H Smith; Lars Lind; Stuart A Scott; Yingchang Lu; Erwin B Bottinger; Jussi Hernesniemi; Cecilia M Lindgren; Jorge A Wong; Jie Huang; Markku Eskola; Andrew P Morris; Ian Ford; Alex P Reiner; Graciela Delgado; Lin Y Chen; Yii-Der Ida Chen; Roopinder K Sandhu; Man Li; Eric Boerwinkle; Lewin Eisele; Lars Lannfelt; Natalia Rost; Christopher D Anderson; Kent D Taylor; Archie Campbell; Patrik K Magnusson; David Porteous; Lynne J Hocking; Efthymia Vlachopoulou; Nancy L Pedersen; Kjell Nikus; Marju Orho-Melander; Anders Hamsten; Jan Heeringa; Joshua C Denny; Jennifer Kriebel; Dawood Darbar; Christopher Newton-Cheh; Christian Shaffer; Peter W Macfarlane; Stefanie Heilmann-Heimbach; Peter Almgren; Paul L Huang; Nona Sotoodehnia; Elsayed Z Soliman; Andre G Uitterlinden; Albert Hofman; Oscar H Franco; Uwe Völker; Karl-Heinz Jöckel; Moritz F Sinner; Henry J Lin; Xiuqing Guo; Martin Dichgans; Erik Ingelsson; Charles Kooperberg; Olle Melander; Ruth J F Loos; Jari Laurikka; David Conen; Jonathan Rosand; Pim van der Harst; Marja-Liisa Lokki; Sekar Kathiresan; Alexandre Pereira; J Wouter Jukema; Caroline Hayward; Jerome I Rotter; Winfried März; Terho Lehtimäki; Bruno H Stricker; Mina K Chung; Stephan B Felix; Vilmundur Gudnason; Alvaro Alonso; Dan M Roden; Stefan Kääb; Daniel I Chasman; Susan R Heckbert; Emelia J Benjamin; Toshihiro Tanaka; Kathryn L Lunetta; Steven A Lubitz; Patrick T Ellinor
Journal:  Nat Genet       Date:  2017-04-17       Impact factor: 41.307

10.  Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:  Carolina Roselli; Mark D Chaffin; Lu-Chen Weng; Stefanie Aeschbacher; Gustav Ahlberg; Christine M Albert; Peter Almgren; Alvaro Alonso; Christopher D Anderson; Krishna G Aragam; Dan E Arking; John Barnard; Traci M Bartz; Emelia J Benjamin; Nathan A Bihlmeyer; Joshua C Bis; Heather L Bloom; Eric Boerwinkle; Erwin B Bottinger; Jennifer A Brody; Hugh Calkins; Archie Campbell; Thomas P Cappola; John Carlquist; Daniel I Chasman; Lin Y Chen; Yii-Der Ida Chen; Eue-Keun Choi; Seung Hoan Choi; Ingrid E Christophersen; Mina K Chung; John W Cole; David Conen; James Cook; Harry J Crijns; Michael J Cutler; Scott M Damrauer; Brian R Daniels; Dawood Darbar; Graciela Delgado; Joshua C Denny; Martin Dichgans; Marcus Dörr; Elton A Dudink; Samuel C Dudley; Nada Esa; Tonu Esko; Markku Eskola; Diane Fatkin; Stephan B Felix; Ian Ford; Oscar H Franco; Bastiaan Geelhoed; Raji P Grewal; Vilmundur Gudnason; Xiuqing Guo; Namrata Gupta; Stefan Gustafsson; Rebecca Gutmann; Anders Hamsten; Tamara B Harris; Caroline Hayward; Susan R Heckbert; Jussi Hernesniemi; Lynne J Hocking; Albert Hofman; Andrea R V R Horimoto; Jie Huang; Paul L Huang; Jennifer Huffman; Erik Ingelsson; Esra Gucuk Ipek; Kaoru Ito; Jordi Jimenez-Conde; Renee Johnson; J Wouter Jukema; Stefan Kääb; Mika Kähönen; Yoichiro Kamatani; John P Kane; Adnan Kastrati; Sekar Kathiresan; Petra Katschnig-Winter; Maryam Kavousi; Thorsten Kessler; Bas L Kietselaer; Paulus Kirchhof; Marcus E Kleber; Stacey Knight; Jose E Krieger; Michiaki Kubo; Lenore J Launer; Jari Laurikka; Terho Lehtimäki; Kirsten Leineweber; Rozenn N Lemaitre; Man Li; Hong Euy Lim; Henry J Lin; Honghuang Lin; Lars Lind; Cecilia M Lindgren; Marja-Liisa Lokki; Barry London; Ruth J F Loos; Siew-Kee Low; Yingchang Lu; Leo-Pekka Lyytikäinen; Peter W Macfarlane; Patrik K Magnusson; Anubha Mahajan; Rainer Malik; Alfredo J Mansur; Gregory M Marcus; Lauren Margolin; Kenneth B Margulies; Winfried März; David D McManus; Olle Melander; Sanghamitra Mohanty; Jay A Montgomery; Michael P Morley; Andrew P Morris; Martina Müller-Nurasyid; Andrea Natale; Saman Nazarian; Benjamin Neumann; Christopher Newton-Cheh; Maartje N Niemeijer; Kjell Nikus; Peter Nilsson; Raymond Noordam; Heidi Oellers; Morten S Olesen; Marju Orho-Melander; Sandosh Padmanabhan; Hui-Nam Pak; Guillaume Paré; Nancy L Pedersen; Joanna Pera; Alexandre Pereira; David Porteous; Bruce M Psaty; Sara L Pulit; Clive R Pullinger; Daniel J Rader; Lena Refsgaard; Marta Ribasés; Paul M Ridker; Michiel Rienstra; Lorenz Risch; Dan M Roden; Jonathan Rosand; Michael A Rosenberg; Natalia Rost; Jerome I Rotter; Samir Saba; Roopinder K Sandhu; Renate B Schnabel; Katharina Schramm; Heribert Schunkert; Claudia Schurman; Stuart A Scott; Ilkka Seppälä; Christian Shaffer; Svati Shah; Alaa A Shalaby; Jaemin Shim; M Benjamin Shoemaker; Joylene E Siland; Juha Sinisalo; Moritz F Sinner; Agnieszka Slowik; Albert V Smith; Blair H Smith; J Gustav Smith; Jonathan D Smith; Nicholas L Smith; Elsayed Z Soliman; Nona Sotoodehnia; Bruno H Stricker; Albert Sun; Han Sun; Jesper H Svendsen; Toshihiro Tanaka; Kahraman Tanriverdi; Kent D Taylor; Maris Teder-Laving; Alexander Teumer; Sébastien Thériault; Stella Trompet; Nathan R Tucker; Arnljot Tveit; Andre G Uitterlinden; Pim Van Der Harst; Isabelle C Van Gelder; David R Van Wagoner; Niek Verweij; Efthymia Vlachopoulou; Uwe Völker; Biqi Wang; Peter E Weeke; Bob Weijs; Raul Weiss; Stefan Weiss; Quinn S Wells; Kerri L Wiggins; Jorge A Wong; Daniel Woo; Bradford B Worrall; Pil-Sung Yang; Jie Yao; Zachary T Yoneda; Tanja Zeller; Lingyao Zeng; Steven A Lubitz; Kathryn L Lunetta; Patrick T Ellinor
Journal:  Nat Genet       Date:  2018-06-11       Impact factor: 38.330
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