| Literature DB >> 29892015 |
Carolina Roselli1, Mark D Chaffin1, Lu-Chen Weng1,2, Stefanie Aeschbacher3,4, Gustav Ahlberg5,6,7, Christine M Albert8, Peter Almgren9, Alvaro Alonso10, Christopher D Anderson1,11, Krishna G Aragam1,11, Dan E Arking12, John Barnard13, Traci M Bartz14, Emelia J Benjamin15,16,17, Nathan A Bihlmeyer18, Joshua C Bis19, Heather L Bloom20, Eric Boerwinkle21, Erwin B Bottinger22,23, Jennifer A Brody19, Hugh Calkins24, Archie Campbell25, Thomas P Cappola26, John Carlquist27,28, Daniel I Chasman1,29, Lin Y Chen30, Yii-Der Ida Chen31, Eue-Keun Choi32, Seung Hoan Choi1, Ingrid E Christophersen1,2,33, Mina K Chung13, John W Cole34,35, David Conen3,4,36, James Cook37, Harry J Crijns38, Michael J Cutler27, Scott M Damrauer39,40, Brian R Daniels1, Dawood Darbar41, Graciela Delgado42, Joshua C Denny43, Martin Dichgans44,45,46, Marcus Dörr47,48, Elton A Dudink38, Samuel C Dudley49, Nada Esa50, Tonu Esko1,51, Markku Eskola52, Diane Fatkin53,54,55, Stephan B Felix47,48, Ian Ford56, Oscar H Franco57, Bastiaan Geelhoed58, Raji P Grewal59,60, Vilmundur Gudnason61,62, Xiuqing Guo31, Namrata Gupta1, Stefan Gustafsson63, Rebecca Gutmann64, Anders Hamsten65, Tamara B Harris66, Caroline Hayward67, Susan R Heckbert68,69, Jussi Hernesniemi52,70, Lynne J Hocking71, Albert Hofman57, Andrea R V R Horimoto72, Jie Huang73, Paul L Huang2, Jennifer Huffman67, Erik Ingelsson63,74, Esra Gucuk Ipek24, Kaoru Ito75, Jordi Jimenez-Conde76,77, Renee Johnson53, J Wouter Jukema78,79,80, Stefan Kääb81,82, Mika Kähönen83, Yoichiro Kamatani84, John P Kane85, Adnan Kastrati82,86, Sekar Kathiresan1,11, Petra Katschnig-Winter87, Maryam Kavousi57, Thorsten Kessler86, Bas L Kietselaer38, Paulus Kirchhof88,89,90, Marcus E Kleber42, Stacey Knight27,91, Jose E Krieger72, Michiaki Kubo92, Lenore J Launer66, Jari Laurikka93, Terho Lehtimäki70, Kirsten Leineweber94, Rozenn N Lemaitre19, Man Li95,96, Hong Euy Lim97, Henry J Lin31, Honghuang Lin15,16, Lars Lind98, Cecilia M Lindgren99, Marja-Liisa Lokki100, Barry London64, Ruth J F Loos22,101,102, Siew-Kee Low84, Yingchang Lu22,101, Leo-Pekka Lyytikäinen70, Peter W Macfarlane103, Patrik K Magnusson104, Anubha Mahajan99, Rainer Malik44, Alfredo J Mansur105, Gregory M Marcus106, Lauren Margolin1, Kenneth B Margulies26, Winfried März107,108, David D McManus50, Olle Melander109, Sanghamitra Mohanty110,111, Jay A Montgomery43, Michael P Morley26, Andrew P Morris37, Martina Müller-Nurasyid81,82,112, Andrea Natale110,111, Saman Nazarian113, Benjamin Neumann81, Christopher Newton-Cheh1,11, Maartje N Niemeijer57, Kjell Nikus52, Peter Nilsson114, Raymond Noordam115, Heidi Oellers116, Morten S Olesen5,6,7, Marju Orho-Melander9, Sandosh Padmanabhan117, Hui-Nam Pak118, Guillaume Paré36,119, Nancy L Pedersen104, Joanna Pera120, Alexandre Pereira121,122, David Porteous25, Bruce M Psaty69,123, Sara L Pulit1,124,125, Clive R Pullinger85, Daniel J Rader126, Lena Refsgaard5,6,7, Marta Ribasés127,128,129, Paul M Ridker8, Michiel Rienstra58, Lorenz Risch130,131, Dan M Roden43, Jonathan Rosand1,11, Michael A Rosenberg11,132, Natalia Rost1,133, Jerome I Rotter134, Samir Saba135, Roopinder K Sandhu136, Renate B Schnabel137,138, Katharina Schramm81,112, Heribert Schunkert82,86, Claudia Schurman22,101, Stuart A Scott139, Ilkka Seppälä70, Christian Shaffer43, Svati Shah140, Alaa A Shalaby135,141, Jaemin Shim142, M Benjamin Shoemaker43, Joylene E Siland58, Juha Sinisalo143, Moritz F Sinner81,82, Agnieszka Slowik120, Albert V Smith61,62, Blair H Smith144, J Gustav Smith1,145, Jonathan D Smith13, Nicholas L Smith68,69, Elsayed Z Soliman146, Nona Sotoodehnia147, Bruno H Stricker148,149, Albert Sun140, Han Sun13, Jesper H Svendsen5,7, Toshihiro Tanaka150, Kahraman Tanriverdi50, Kent D Taylor31, Maris Teder-Laving51, Alexander Teumer48,151, Sébastien Thériault36,119, Stella Trompet78,115, Nathan R Tucker1,2, Arnljot Tveit33,152, Andre G Uitterlinden148, Pim Van Der Harst58, Isabelle C Van Gelder58, David R Van Wagoner13, Niek Verweij58, Efthymia Vlachopoulou100, Uwe Völker48,153, Biqi Wang154, Peter E Weeke5,43, Bob Weijs38, Raul Weiss155, Stefan Weiss48,153, Quinn S Wells43, Kerri L Wiggins19, Jorge A Wong156, Daniel Woo157, Bradford B Worrall158, Pil-Sung Yang118, Jie Yao31, Zachary T Yoneda43, Tanja Zeller137,138, Lingyao Zeng86, Steven A Lubitz1,2,159, Kathryn L Lunetta15,154, Patrick T Ellinor160,161,162.
Abstract
Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.Entities:
Mesh：
Year: 2018 PMID： 29892015 PMCID： PMC6136836 DOI： 10.1038/s41588-018-0133-9
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330