Literature DB >> 3557453

Hypothesis regarding the nature of the fragile X mutation. A reply to Winter and Pembrey.

W T Brown, S L Sherman, C S Dobkin.   

Abstract

Pembrey et al. (1985) proposed a hypothesis regarding the nature of the fragile X [fra(X)] mutation. Recently they analyzed DNA linkage data (Winter and Pembrey 1986) that we and others have published on fra(X) pedigrees, found significant linkage heterogeneity, and modified their hypothesis to explain the observations. We would like to point out that their modified hypothesis is not supported by the data available.

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Year:  1987        PMID： 3557453     DOI： 10.1007/BF00281078

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  Linkage studies of X-linked mental retardation: high frequency of recombination in the telomeric region of the human X chromosome (fragile site/linkage/recombination/X chromosome).

Authors:  K E Davies; M G Mattei; J F Mattei; H Veenema; S McGlade; K Harper; N Tommerup; K B Nielsen; M Mikkelsen; P Beighton
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

2.  DNA linkage studies in the fragile X syndrome suggest genetic heterogeneity.

Authors:  W T Brown; A C Gross; C B Chan; E C Jenkins
Journal:  Am J Med Genet       Date:  1986 Jan-Feb

3.  Recombination and amplification of pyrimidine-rich sequences may be responsible for initiation and progression of the Xq27 fragile site: an hypothesis.

Authors:  R L Nussbaum; S D Airhart; D H Ledbetter
Journal:  Am J Med Genet       Date:  1986 Jan-Feb

4.  Analysis of linkage relationships between genetic markers around the fragile X locus with special reference to the daughters of normal transmitting males.

Authors:  R M Winter; M E Pembrey
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

5.  The marker (X) syndrome: a cytogenetic and genetic analysis.

Authors:  S L Sherman; N E Morton; P A Jacobs; G Turner
Journal:  Ann Hum Genet       Date:  1984-01       Impact factor: 1.670

6.  The genetic linkage map of the human X chromosome.

Authors:  D Drayna; R White
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

7.  Genetic analysis of the fragile-X mental retardation syndrome with two flanking polymorphic DNA markers.

Authors:  I Oberlé; R Heilig; J P Moisan; C Kloepfer; G M Mattéi; J F Mattéi; J Boué; U Froster-Iskenius; P A Jacobs; G M Lathrop
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

8.  Further segregation analysis of the fragile X syndrome with special reference to transmitting males.

Authors:  S L Sherman; P A Jacobs; N E Morton; U Froster-Iskenius; P N Howard-Peebles; K B Nielsen; M W Partington; G R Sutherland; G Turner; M Watson
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

9.  Further evidence for genetic heterogeneity in the fragile X syndrome.

Authors:  W T Brown; E C Jenkins; A C Gross; C B Chan; M S Krawczun; C J Duncan; S L Sklower; G S Fisch
Journal:  Hum Genet       Date:  1987-04       Impact factor: 4.132

10.  Genetic linkage heterogeneity in the fragile X syndrome.

Authors:  W T Brown; A C Gross; C B Chan; E C Jenkins
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132
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  3 in total

1.  The role of recombination in the evolvement of the fragile X mutation.

Authors:  T Schaap
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

2.  Interpretation of the heterogeneity in the linkage relationships of DNA markers around the fragile X locus.

Authors:  R Winter; M Pembrey
Journal:  Hum Genet       Date:  1987-11       Impact factor: 4.132

3.  Linkage analysis using multiple DNA polymorphic markers in normal families and in families with fragile X syndrome.

Authors:  S N Thibodeau; H R Dorkins; K R Faulk; R Berry; A C Smith; R Hagerman; A King; K E Davies
Journal:  Hum Genet       Date:  1988-07       Impact factor: 4.132
  3 in total

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