Literature DB >> 3552907

Immunohistochemical localisation of vitamin B12 R-binder in the human digestive tract.

H Kudo, M Inada, G Ohshio, Y Wakatsuki, K Ogawa, Y Hamashima, T Miyake.   

Abstract

The distribution of vitamin B12 R-binder in the human digestive tract was studied using an indirect immunoperoxidase technique. Positive staining for R-binder was found in the mucous cells and ductal epithelial cells of the salivary glands and the oesophageal glands. In normal gastric mucosa, no positive staining for R-binder was found, but in the area with intestinal metaplasia, the columnar epithelial cells and goblet cells showed positive staining. Epithelial cells of the gallbladder, intrahepatic bile ducts and pancreatic ducts were also positive for R-binder. In the small intestine and colon, R-binder was found in the columnar epithelial cells and goblet cells. The measurement of unsaturated vitamin B12 binding capacity and cobalamin content in the extracts from intestinal mucosa also indicated the presence of R-binder in the intestinal mucosa.

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Year:  1987        PMID： 3552907      PMCID： PMC1432707          DOI： 10.1136/gut.28.3.339

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  13 in total

1.  Measurement of unsaturated ""granulocyte-related'' (TC I and TC III) and ""liver-related'' (TC II) B12 binders by instant batch separation using a microfine precipitate of silica (QUSO G32).

Authors:  E Jacob; V Herbert
Journal:  J Lab Clin Med       Date:  1975-09

2.  Vitamin B12-binding proteins in human gastric mucosa. General pattern and demonstration of intrinsic factor isoproteins typical of mucosa.

Authors:  G Marcoullis; R Gräsbeck
Journal:  Scand J Clin Lab Invest       Date:  1975-01       Impact factor: 1.713

Review 3.  Possible antimicrobial function of the large molecular size vitamin B12-binding protein.

Authors:  R Gullberg
Journal:  Scand J Gastroenterol Suppl       Date:  1974

4.  Isolation of vitamin B12-binding proteins using affinity chromatography. I. Preparation and properties of vitamin B12-sepharose.

Authors:  R H Allen; P W Majerus
Journal:  J Biol Chem       Date:  1972-12-10       Impact factor: 5.157

5.  Isolation of gastric vitamin B 12 -binding proteins using affinity chromatography. I. Purification and properties of human intrinsic factor.

Authors:  R H Allen; C S Mehlman
Journal:  J Biol Chem       Date:  1973-05-25       Impact factor: 5.157

6.  Characterization of vitamin B12-binding proteins isolated from human milk and saliva by affinity chromatography.

Authors:  R L Burger; R H Allen
Journal:  J Biol Chem       Date:  1974-11-25       Impact factor: 5.157

7.  Production of vitamin B 12 analogues in patients with small-bowel bacterial overgrowth.

Authors:  L J Brandt; L H Bernstein; A Wagle
Journal:  Ann Intern Med       Date:  1977-11       Impact factor: 25.391

8.  Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption.

Authors:  I Chanarin; M Muir; A Hughes; A V Hoffbrand
Journal:  Br Med J       Date:  1978-06-03

9.  Vitamin B12 synthesis by human small intestinal bacteria.

Authors:  M J Albert; V I Mathan; S J Baker
Journal:  Nature       Date:  1980-02-21       Impact factor: 49.962

10.  RAPID CHARCOAL ASSAY FOR INTRINSIC FACTOR (IF), GASTRIC JUICE UNSATURATED B12 BINDING CAPACITY, ANTIBODY TO IF, AND SERUM UNSATURATED B12 BINDING CAPACITY.

Authors:  K S GOTTLIEBLAU; L R WASSERMAN; V HERBERT
Journal:  Blood       Date:  1965-06       Impact factor: 22.113
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  5 in total

1.  Morphometric analysis of mucous granule depletion and replenishment in rat colon.

Authors:  T E Phillips; J Wilson
Journal:  Dig Dis Sci       Date:  1993-12       Impact factor: 3.199

2.  Cellular localization of intrinsic factor in pancreas and stomach of the dog.

Authors:  C Vaillant; N U Horadagoda; R M Batt
Journal:  Cell Tissue Res       Date:  1990-04       Impact factor: 5.249

3.  Distribution of vitamin B12 R-binder in carcinomas of the digestive tract.

Authors:  H Kudo; G Ohshio; K Ogawa; Y C Kim; Y Wakatsuki; Y Nakashima; H Yamabe; M Inada
Journal:  J Clin Pathol       Date:  1988-03       Impact factor: 3.411

4.  Expression of sialosyl-Tn antigen (monoclonal antibody MLS102 reactive) in normal tissues and malignant tumors of the digestive tract.

Authors:  G Ohshio; H Yoshioka; T Manabe; H Sakahara; H Yamabe; M Imamura; M Inoue; N Tanaka; H Nakada; I Yamashina
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

5.  Immunohistochemical distribution of vitamin B12 R-binder in renal cell carcinoma.

Authors:  K Ogawa; H Kudo; Y C Kim; Y Nakashima; G Ohshio; H Yamabe; M Inada; Y Hamashima
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1987
  5 in total

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