Literature DB >> 647333

Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption.

I Chanarin, M Muir, A Hughes, A V Hoffbrand.   

Abstract

The plasma binding of newly absorbed, radioactively labelled vitamin B12 was studied during a urinary excretion (Schilling) test. Vitamin B12, after being absorbed from the gut, enters blood attached to transcobalamin II, which seems to be derived from the ileal enterocyte. The absorbed B12 re-enters the blood stream after the transcobalamin II-B12 complex is cleared by the liver and it is then excreted into the urine during the Schilling test.

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Year:  1978        PMID： 647333      PMCID： PMC1604897          DOI： 10.1136/bmj.1.6125.1453

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  4 in total

1.  Absorption of vitamin B 12 by the guinea-pig. I. Subcellular localization of vitamin B 12 in the ileal enterocyte during absorption.

Authors:  T J Peters; A V Hoffbrand
Journal:  Br J Haematol       Date:  1970-09       Impact factor: 6.998

2.  Plasma turnover of 57cobalt-vitamin B12 bound to transcobalamin I and II.

Authors:  B L Hom
Journal:  Scand J Haematol       Date:  1967

3.  Studies on the transcobalamins.

Authors:  J M England; H G Clarke; M C Down; I Chanarin
Journal:  Br J Haematol       Date:  1973-12       Impact factor: 6.998

4.  Measurement of vitamin B12-binding proteins of plasma. I. Technique.

Authors:  J A Begley; C A Hall
Journal:  Blood       Date:  1975-02       Impact factor: 22.113
  4 in total
  10 in total

1.  Synthesis and secretion of a cobalamin-binding protein by HT 29 cell line.

Authors:  H Schohn; J L Guéant; M Girr; E Nexø; L Baricault; A Zweibaum; J P Nicolas
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

Review 2.  Vitamin B12 absorption and malabsorption.

Authors:  H Schjønsby
Journal:  Gut       Date:  1989-12       Impact factor: 23.059

Review 3.  Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor.

Authors:  Edward V Quadros; Jeffrey M Sequeira
Journal:  Biochimie       Date:  2013-02-14       Impact factor: 4.079

Review 4.  Advances in the understanding of cobalamin assimilation and metabolism.

Authors:  Edward V Quadros
Journal:  Br J Haematol       Date:  2009-10-12       Impact factor: 6.998

5.  Immunohistochemical localisation of vitamin B12 R-binder in the human digestive tract.

Authors:  H Kudo; M Inada; G Ohshio; Y Wakatsuki; K Ogawa; Y Hamashima; T Miyake
Journal:  Gut       Date:  1987-03       Impact factor: 23.059

6.  Intrinsic factor-mediated absorption of cobalamin by guinea pig ileal cells.

Authors:  C R Kapadia; D Serfilippi; K Voloshin; R M Donaldson
Journal:  J Clin Invest       Date:  1983-03       Impact factor: 14.808

7.  Expression of transcobalamin II mRNA in human tissues and cultured fibroblasts from normal and transcobalamin II-deficient patients.

Authors:  N Li; S Seetharam; D S Rosenblatt; B Seetharam
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857

8.  The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin.

Authors:  Edward V Quadros; Yasumi Nakayama; Jeffrey M Sequeira
Journal:  Blood       Date:  2008-09-08       Impact factor: 22.113

Review 9.  Genetic patterns of transcobalamin II and the relationships with congenital defects.

Authors:  M Fràter-Schröder
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

10.  Structural basis of transcobalamin recognition by human CD320 receptor.

Authors:  Amer Alam; Jae-Sung Woo; Jennifer Schmitz; Bernadette Prinz; Katharina Root; Fan Chen; Joël S Bloch; Renato Zenobi; Kaspar P Locher
Journal:  Nat Commun       Date:  2016-07-14       Impact factor: 14.919
  10 in total

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