Literature DB >> 3549472

Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis.

G D Barr, M J Hudson, J D Priddle, D P Jewell.   

Abstract

The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such enzyme production by colonic bacteria plays a significant role in the pathogenesis of ulcerative colitis.

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Year:  1987        PMID： 3549472      PMCID： PMC1432971          DOI： 10.1136/gut.28.2.186

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  19 in total

1.  Studies of intestinal microflora. V. Fecal microbial ecology in ulcerative colitis and regional enteritis: relationship to severity of disease and chemotherapy.

Authors:  S L Gorbach; L Nahas; A G Plaut; L Weinstein; J F Patterson; R Levitan
Journal:  Gastroenterology       Date:  1968-04       Impact factor: 22.682

2.  Studies on human secretory immunoglobulin A. II. Subunit structure.

Authors:  J Mestecky; R Kulhavy; F W Kraus
Journal:  J Immunol       Date:  1972-03       Impact factor: 5.422

3.  Human immunoglobulin A: production of an Fc fragment by an enteric microbial proteolytic enzyme.

Authors:  S K Mehta; A G Plaut; N J Calvanico; T B Tomasi
Journal:  J Immunol       Date:  1973-10       Impact factor: 5.422

4.  Transport and storage of faeces for bacteriological examination.

Authors:  J S Crowther
Journal:  J Appl Bacteriol       Date:  1971-06

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  The microbial flora of the rectal mucosa and faeces of patients with Crohn's disease before and during antimicrobial chemotherapy.

Authors:  M J Hudson; M J Hill; P R Elliott; L M Berghouse; W R Burnham; J E Lennard-Jones
Journal:  J Med Microbiol       Date:  1984-12       Impact factor: 2.472

7.  Medium without rumen fluid for nonselective enumeration and isolation of rumen bacteria.

Authors:  D R Caldwell; M P Bryant
Journal:  Appl Microbiol       Date:  1966-09

8.  Properties of strains of Escherichia coli isolated from the faeces of patients with ulcerative colitis, patients with acute diarrhoea and normal persons.

Authors:  E M Cooke
Journal:  J Pathol Bacteriol       Date:  1968-01

9.  Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A.

Authors:  A G Plaut; J V Gilbert; M S Artenstein; J D Capra
Journal:  Science       Date:  1975-12-12       Impact factor: 47.728

10.  A subclass of human gamma-A-globulins (gamma-A2) which lacks the disulfied bonds linking heavy and light chains.

Authors:  H M Grey; C A Abel; W J Yount; H G Kunkel
Journal:  J Exp Med       Date:  1968-12-01       Impact factor: 14.307
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