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Literature DB >> 4176936

A subclass of human gamma-A-globulins (gamma-A2) which lacks the disulfied bonds linking heavy and light chains.

H M Grey, C A Abel, W J Yount, H G Kunkel.

Abstract

The gammaA2-subgroup of gammaA-globulins, previously delineated by antigenic studies, was found to differ strikingly from other immunoglobulins in the manner in which the polypeptide chains are bound together. The heavy and light chains were not linked to each other by disulfide bonds. Instead the light chains were disulfide linked to one another, and were present in the gammaA2-molecule as disulfide bridged L-L dimers. Antisera specific for gammaA2-proteins indicated the occurrence of two different antigenic types in all normal sera as well as saliva and colostrum. Both of these showed the unique interchain disulfide linkage. Quantitative analyses indicated higher levels of gammaA2-proteins in external secretions.

Entities: Chemical Species

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Year: 1968 PMID： 4176936 PMCID： PMC2138581 DOI： 10.1084/jem.128.6.1223

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

18 in total

1. Reduction of gamma-globulins.

Authors: J B FLEISCHMAN; R H PAIN; R R PORTER
Journal: Arch Biochem Biophys Date: 1962-09 Impact factor: 4.013

2. The use of urea-starch-gel electrophoresis in studies of reductive cleavage of an alpha 2-macroglobulin.

Authors: M D POULIK
Journal: Biochim Biophys Acta Date: 1960-11-04

3. The evolutionary origins of the immunoglobulins.

Authors: R L Hill; R Delaney; R E Fellows; H E Lebovitz
Journal: Proc Natl Acad Sci U S A Date: 1966-12 Impact factor: 11.205

4. Zone electrophoresis.

Authors: H G KUNKEL
Journal: Methods Biochem Anal Date: 1954

5. Subgroups of gamma-A immune globulins.

Authors: H G Kunkel; R A Prendergast
Journal: Proc Soc Exp Biol Med Date: 1966-07

6. Polypeptide chain structure of rabbit immunoglobulins. 3. Secretory gamma-A-immunoglobulin from colostrum.

Authors: J J Cebra; P A Small
Journal: Biochemistry Date: 1967-02 Impact factor: 3.162

7. Studies on the structure of mouse gamma-A myeloma proteins.

Authors: C A Abel; H M Grey
Journal: Biochemistry Date: 1968-07 Impact factor: 3.162

8. Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteins.

Authors: B Frangione; C Milstein
Journal: J Mol Biol Date: 1968-05-14 Impact factor: 5.469

9. Distribution of alpha-chain subclasses in normal and pathological IgA-globulins.

Authors: J P Vaerman; J F Heremans; C B Laurell
Journal: Immunology Date: 1968-03 Impact factor: 7.397

10. Studies on human antibodies. VI. Selective variations in subgroup composition and genetic markers.

Authors: W J Yount; M M Dorner; H G Kunkel; E A Kabat
Journal: J Exp Med Date: 1968-03-01 Impact factor: 14.307

46 in total

1. The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses.

Authors: Alexandra Bonner; Adel Almogren; Patricia B Furtado; Michael A Kerr; Stephen J Perkins
Journal: J Biol Chem Date: 2008-12-23 Impact factor: 5.157

2. Porcine IgG: structure, genetics, and evolution.

Authors: J E Butler; Nancy Wertz; Nicholas Deschacht; Imre Kacskovics
Journal: Immunogenetics Date: 2008-12-02 Impact factor: 2.846

3. Detection of immunoglobulin A1 protease-induced Fab alpha fragments on dental plaque bacteria.

Authors: T Ahl; J Reinholdt
Journal: Infect Immun Date: 1991-02 Impact factor: 3.441

4. Molecular size heterogeneity of immunoglobulins in health and disease.

Authors: P J Roberts-Thomson; K Shepherd
Journal: Clin Exp Immunol Date: 1990-03 Impact factor: 4.330

5. IgA subclasses of human colostral antibodies specific for microbial and food antigens.

Authors: I Ladjeva; J H Peterman; J Mestecky
Journal: Clin Exp Immunol Date: 1989-10 Impact factor: 4.330

6. Subclass distribution of IgA antibodies in saliva and serum after immunization with Haemophilus influenzae type b conjugate vaccines.

Authors: M Kauppi-Korkeila; L Saarinen; J Eskola; H Käyhty
Journal: Clin Exp Immunol Date: 1998-02 Impact factor: 4.330

Review 7. The demonstration and function of antibodies in the gastrointestinal tract.

Authors: D J Shearman; D M Parkin; D B McClelland
Journal: Gut Date: 1972-06 Impact factor: 23.059

8. An immunological study during post-transplantation follow-up of a case of severe combined immunodeficiency.

Authors: J Rádl; L J Dooren; V P Eijsvoogel; J J van Went; W Hijmans
Journal: Clin Exp Immunol Date: 1972-02 Impact factor: 4.330

Review 9. Immunocytoma o' mice an' men.

Authors: J R Hobbs
Journal: Br Med J Date: 1971-04-10

10. Am(1), the first genetic marker of human immunoglobulin A.

Authors: G N Vyas; H H Fudenberg
Journal: Proc Natl Acad Sci U S A Date: 1969-12 Impact factor: 11.205