| Literature DB >> 810892 |
A G Plaut, J V Gilbert, M S Artenstein, J D Capra.
Abstract
The gonococcus and meningococcus, which infect human mucosal surfaces, elaborate a highly specific proteolytic enzyme which cleaves the immunoglobulin A1 subclass of the principal mucosal antibody, immunoglobulin A (IgA). The susceptible Pro-Thr bond lies in a unique region of the IgA heavy chain; the IgA2 subclass, lacking this peptide bond, is enzyme resistant.Entities:
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Year: 1975 PMID： 810892 DOI： 10.1126/science.810892
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728