Literature DB >> 35419471

Mitotic WNT: aligning chromosomes through KIF2A.

Anja Bufe1, Sergio P Acebrón1.   

Abstract

WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure proper chromosome alignment during mitosis through the regulation of kinesin family member 2A (KIF2A).
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Entities:  

Keywords:  PLK1; WNT signaling; chromosome congression; disheveled; kinesin-13

Year:  2021        PMID： 35419471      PMCID： PMC8997256          DOI： 10.1080/23723556.2021.2011564

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  CDK1-mediated BCL9 phosphorylation inhibits clathrin to promote mitotic Wnt signalling.

Authors:  Jianxiang Chen; Muthukumar Rajasekaran; Hongping Xia; Shik Nie Kong; Amudha Deivasigamani; Karthik Sekar; Hengjun Gao; Hannah Lf Swa; Jayantha Gunaratne; London Lucien Ooi; Tian Xie; Wanjin Hong; Kam Man Hui
Journal:  EMBO J       Date:  2018-09-14       Impact factor: 11.598

2.  Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis.

Authors:  Anja Bufe; Ana García Del Arco; Magdalena Hennecke; Anchel de Jaime-Soguero; Matthias Ostermaier; Yu-Chih Lin; Anja Ciprianidis; Janina Hattemer; Ulrike Engel; Petra Beli; Holger Bastians; Sergio P Acebrón
Journal:  Proc Natl Acad Sci U S A       Date:  2021-08-24       Impact factor: 11.205

Review 3.  β-Catenin-Independent Roles of Wnt/LRP6 Signaling.

Authors:  Sergio P Acebron; Christof Niehrs
Journal:  Trends Cell Biol       Date:  2016-08-24       Impact factor: 20.808

4.  Cell cycle control of wnt receptor activation.

Authors:  Gary Davidson; Jinlong Shen; Ya-Lin Huang; Yi Su; Emil Karaulanov; Kerstin Bartscherer; Christine Hassler; Peter Stannek; Michael Boutros; Christof Niehrs
Journal:  Dev Cell       Date:  2009-12       Impact factor: 12.270

5.  Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development.

Authors:  Loïc Broix; Laure Asselin; Carla G Silva; Ekaterina L Ivanova; Peggy Tilly; Johan G Gilet; Nicolas Lebrun; Hélène Jagline; Giuseppe Muraca; Yoann Saillour; Nathalie Drouot; Madeline Louise Reilly; Fiona Francis; Alexandre Benmerah; Nadia Bahi-Buisson; Richard Belvindrah; Laurent Nguyen; Juliette D Godin; Jamel Chelly; Maria-Victoria Hinckelmann
Journal:  Hum Mol Genet       Date:  2018-01-15       Impact factor: 6.150

6.  Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation.

Authors:  Ran Xu; Yixi Xu; Wei Huo; Zhicong Lv; Jingsong Yuan; Shaokai Ning; Qingsong Wang; Mei Hou; Ge Gao; Jianguo Ji; Junjie Chen; Rong Guo; Dongyi Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-08       Impact factor: 11.205

Review 7.  Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Authors:  Roel Nusse; Hans Clevers
Journal:  Cell       Date:  2017-06-01       Impact factor: 41.582

8.  Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

Authors:  Josipa Bilic; Ya-Lin Huang; Gary Davidson; Timo Zimmermann; Cristina-Maria Cruciat; Mariann Bienz; Christof Niehrs
Journal:  Science       Date:  2007-06-15       Impact factor: 47.728

9.  Mitotic spindle scaling during Xenopus development by kif2a and importin α.

Authors:  Jeremy D Wilbur; Rebecca Heald
Journal:  Elife       Date:  2013-02-19       Impact factor: 8.140
  9 in total
  1 in total

1.  Expression of KIF2A, NDC80, CDK1, and CCNB1 in breast cancer patients: Their interaction and linkage with tumor features and prognosis.

Authors:  Cong Wang; Xianxin Xie; Weijie Li; Daqing Jiang
Journal:  J Clin Lab Anal       Date:  2022-08-10       Impact factor: 3.124
  1 in total

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