Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Literature DB >> 28575679

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Abstract

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

Entities: Disease Gene

Keywords: Wnt; cancer; development; stem cells; therapy

Mesh：

Substances：
Wnt Proteins

Year: 2017 PMID： 28575679 DOI： 10.1016/j.cell.2017.05.016

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

Keyword Cloud
Cited

1125 in total

Review 1. Wnt Signaling in vascular eye diseases.

Authors: Zhongxiao Wang; Chi-Hsiu Liu; Shuo Huang; Jing Chen
Journal: Prog Retin Eye Res Date: 2018-12-01 Impact factor: 21.198

Review 2. Regulation of Wnt signaling by protocadherins.

Authors: Kar Men Mah; Joshua A Weiner
Journal: Semin Cell Dev Biol Date: 2017-08-01 Impact factor: 7.727

3. Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2.

Authors: Ali Vural; Stephen M Lanier
Journal: J Cell Sci Date: 2020-09-04 Impact factor: 5.285

4. Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.

Authors: Wei Kan; Michael D Enos; Elgin Korkmazhan; Stefan Muennich; Dong-Hua Chen; Melissa V Gammons; Mansi Vasishtha; Mariann Bienz; Alexander R Dunn; Georgios Skiniotis; William I Weis
Journal: Elife Date: 2020-04-16 Impact factor: 8.140

5. YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness.

Authors: Bing Han; Sujun Yan; Saisai Wei; Jie Xiang; Kangli Liu; Zhanghui Chen; Rongpan Bai; Jinghao Sheng; Zhengping Xu; Xiangwei Gao
Journal: EMBO Rep Date: 2020-02-17 Impact factor: 8.807

Review 6. A regulatory loop connecting WNT signaling and telomere capping: possible therapeutic implications for dyskeratosis congenita.

Authors: Rafael Jesus Fernandez; F Brad Johnson
Journal: Ann N Y Acad Sci Date: 2018-04 Impact factor: 5.691

7. The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.

Authors: Tina Hörbelt; Christopher Tacke; Mariya Markova; Daniella Herzfeld de Wiza; Frederique Van de Velde; Marlies Bekaert; Yves Van Nieuwenhove; Silke Hornemann; Maria Rödiger; Nicole Seebeck; Elisabeth Friedl; Wenke Jonas; G Hege Thoresen; Oliver Kuss; Anke Rosenthal; Volker Lange; Andreas F H Pfeiffer; Annette Schürmann; Bruno Lapauw; Natalia Rudovich; Olga Pivovarova; D Margriet Ouwens
Journal: Diabetologia Date: 2018-05-12 Impact factor: 10.122

8. R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.

Authors: Shiying Liu; Yue Yin; Ruili Yu; Yin Li; Weizhen Zhang
Journal: Biochem Biophys Res Commun Date: 2018-03-19 Impact factor: 3.575

9. Mechanistic basis and efficacy of targeting the β-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors.

Authors: Dyana T Saenz; Warren Fiskus; Christopher P Mill; Dimuthu Perera; Taghi Manshouri; Bernardo H Lara; Vrajesh Karkhanis; Sunil Sharma; Stephen K Horrigan; Prithviraj Bose; Tapan M Kadia; Lucia Masarova; Courtney D DiNardo; Gautam Borthakur; Joseph D Khoury; Koichi Takahashi; Srividya Bhaskara; Charles Y Lin; Michael R Green; Cristian Coarfa; Craig M Crews; Srdan Verstovsek; Kapil N Bhalla
Journal: Blood Date: 2020-04-09 Impact factor: 22.113

Review 10. Osteogenesis imperfecta and therapeutics.

Authors: Roy Morello
Journal: Matrix Biol Date: 2018-03-11 Impact factor: 11.583