Literature DB >> 27568239

β-Catenin-Independent Roles of Wnt/LRP6 Signaling.

Sergio P Acebron1, Christof Niehrs2.   

Abstract

Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GSK3; Wnt/STOP; mitosis; post-transcriptional Wnt signaling; proteolysis; β-catenin

Mesh：

Substances：

Year:  2016        PMID： 27568239     DOI： 10.1016/j.tcb.2016.07.009

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  59 in total

1.  Wnt-pathway Activating Mutations Are Associated with Resistance to First-line Abiraterone and Enzalutamide in Castration-resistant Prostate Cancer.

Authors:  Pedro Isaacsson Velho; Wei Fu; Hao Wang; Nooshin Mirkheshti; Fahad Qazi; Fabiola A S Lima; Farah Shaukat; Michael A Carducci; Samuel R Denmeade; Channing J Paller; Mark C Markowski; Catherine H Marshall; Mario A Eisenberger; Emmanuel S Antonarakis
Journal:  Eur Urol       Date:  2019-06-05       Impact factor: 20.096

2.  Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.

Authors:  Mansi Y Shinde; Simone Sidoli; Katarzyna Kulej; Michael J Mallory; Caleb M Radens; Amanda L Reicherter; Rebecca L Myers; Yoseph Barash; Kristen W Lynch; Benjamin A Garcia; Peter S Klein
Journal:  J Biol Chem       Date:  2017-09-15       Impact factor: 5.157

3.  The self-fulfilling prophecy of pulmonary fibrosis: a selective inspection of pathological signalling loops.

Authors:  Ashley R Rackow; David J Nagel; Claire McCarthy; Jennifer Judge; Shannon Lacy; Margaret A T Freeberg; Thomas H Thatcher; R Matthew Kottmann; Patricia J Sime
Journal:  Eur Respir J       Date:  2020-11-26       Impact factor: 16.671

Review 4.  Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology.

Authors:  Jacquelyn O Russell; Satdarshan P Monga
Journal:  Annu Rev Pathol       Date:  2017-11-10       Impact factor: 23.472

5.  Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Authors:  Georg Emons; Melanie Spitzner; Sebastian Reineke; Janneke Möller; Noam Auslander; Frank Kramer; Yue Hu; Tim Beissbarth; Hendrik A Wolff; Margret Rave-Fränk; Elisabeth Heßmann; Jochen Gaedcke; B Michael Ghadimi; Steven A Johnsen; Thomas Ried; Marian Grade
Journal:  Mol Cancer Res       Date:  2017-08-15       Impact factor: 5.852

6.  Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

Authors:  Pu Wang; Feng Yan; Zhijun Li; Yanbao Yu; Scott E Parnell; Yue Xiong
Journal:  J Clin Invest       Date:  2019-07-25       Impact factor: 14.808

Review 7.  WNT signalling in prostate cancer.

Authors:  Virginia Murillo-Garzón; Robert Kypta
Journal:  Nat Rev Urol       Date:  2017-09-12       Impact factor: 14.432

Review 8.  Wnt Signaling in Hematological Malignancies.

Authors:  Stephanie Grainger; David Traver; Karl Willert
Journal:  Prog Mol Biol Transl Sci       Date:  2017-12-29       Impact factor: 3.622

9.  Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion.

Authors:  Caiqi Ma; Chuanghua Luo; Haofan Yin; Yang Zhang; Wenjun Xiong; Ting Zhang; Tianxiao Gao; Xi Wang; Di Che; Zhenzhen Fang; Lei Li; Jinye Xie; Mao Huang; Liuqing Zhu; Ping Jiang; Weiwei Qi; Ti Zhou; Zhonghan Yang; Wei Wang; Jianxing Ma; Guoquan Gao; Xia Yang
Journal:  Gastric Cancer       Date:  2017-12-14       Impact factor: 7.370

10.  Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis.

Authors:  Babita Madan; Nathan Harmston; Gahyathiri Nallan; Alex Montoya; Peter Faull; Enrico Petretto; David M Virshup
Journal:  J Clin Invest       Date:  2018-11-12       Impact factor: 14.808
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